Burke, A J; Lister, T M; Marshall, J R; Brown, M J B; Lloyd, R; Green, A P; Turner, N J

Engineered Biocatalysts for Enantioselective Reductive Aminations of Cyclic Secondary Amines (Journal Article)

ChemCatChem, pp. e202300256, 2023.

(Links | BibTeX)

Xiang, H; Ferla, S; Varricchio, C; Brancale, A; Brown, N L; Black, G W; Turner, N J; Castagnolo, D

Biocatalytic and Chemo-Enzymatic Synthesis of Quinolines and 2-Quinolones by Monoamine Oxidase (MAO-N) and Horseradish Peroxidase (HRP) Biocatalysts (Journal Article)

ACS Catalysis, 13 (5), pp. 3370–3378, 2023.

(Links | BibTeX)

Sangster, J J; Ruscoe, R E; Cosgrove, S C; Mangas-Sánchez, J; Turner, N J

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines (Journal Article)

JACS, 145 (8), pp. 4431–4437, 2023.

(Links | BibTeX)

Gilio, A K; Thorpe, T W; Heyam, A; Petchey, M R; Pogrányi, B; France, S P; Howard, R M; Karmilowicz, M J; Lewis, R; Turner, N J; Grogan, G

A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate (Journal Article)

ACS Catalysis, 13 (3), pp. 1669–1677, 2023.

(Links | BibTeX)

Schnepel, C; Pérez, Rodríguez‎‎ L; Yu, Y; Angelastro, A; Heath, R S; Lubberink, M; Falcioni, F; Mulholland, K; Hayes, M A; Turner, N J; Flitsch, S L

Thioester-mediated biocatalytic amide bond synthesis with in situ thiol recycling (Journal Article)

Nature Catalysis, 6 , pp. 89–99, 2022.

(Links | BibTeX)

Büchler, J; Hegarty, E; Schroer, K; Snajdrova, R; Turner, N J; Loiseleur, O; Buller, R; Chapelain, Le C

A Collaborative Journey towards the Late-Stage Functionalization of Added-Value Chemicals Using Engineered Halogenases (Journal Article)

Helvetica Chimica Acta, 106 (1), pp. e202200128, 2022.

(Links | BibTeX)

Harawa, V; Thorpe, T W; Marshall, J R; Sangster, J J; Gilio, A K; Pirvu, L; Heath, R S; Angelastro, A; Finnigan, J D; Charnock, S J; Nafie, J W; Grogan, G; Whitehead, R C; Turner, N J

Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines (Journal Article)

JACS, 144 (46), pp. 21088–21095, 2022.

(Links | BibTeX)

Young, R J; Flitsch, S L; Grigalunas, M; Leeson, P D; Quinn, R J; Turner, N J; Waldmann, H

The Time and Place for Nature in Drug Discovery (Journal Article)

JACS Au, 2 (11), pp. 2400-2416, 2022.

(Links | BibTeX)

Cheng, B; Heath, R S; Turner, N J; Armstrong, F A; Megarity, C F

Deracemisation and stereoinversion by a nanoconfined bidirectional enzyme cascade: dual control by electrochemistry and selective metal ion activation (Journal Article)

Chemical Communications, 58 , pp. 11713-11716, 2022.

(Links | BibTeX)

Ford, G J; Swanson, C R; Bradshaw-Allen, R T; Marshall, J R; Mattey, A P; Turner, N J; Clapés, P; Flitsch, S L

Three-Component Stereoselective Enzymatic Synthesis of Amino-Diols and Amino-Polyols (Journal Article)

JACS Au, 2 (10), pp. 2251–2258, 2022.

(Links | BibTeX)

Heath, R S; Turner, N J

Recent Advances in Oxidase Biocatalysts: Enzyme Discovery, Cascade Reactions and Scale Up (Journal Article)

Current Opinion in Green and Sustainable Chemistry, 38 , pp. 100693, 2022.

(Links | BibTeX)

Megarity, C F; Weald, T R I; Heath, R S; Turner, N J; Armstrong, F A

A Nanoconfined Four-Enzyme Cascade Simultaneously Driven by Electrical and Chemical Energy, with Built-in Rapid, Confocal Recycling of NADP(H) and ATP (Journal Article)

ACS Catalysis, 12 (15), pp. 8811–8821, 2022.

(Links | BibTeX)

Gilio, A K; Thorpe, T; Turner, N J; Grogan, G

Reductive Aminations by Imine Reductases: From Milligrams to Tons (Journal Article)

Chemical Science, 2 (6), pp. 1494-1498, 2022.

(Links | BibTeX)

Liu, J; Kong, W; Bai, J; Li, Y; Dong, L; Zhou, L; Liu, T; Gao, J; Bradshaw-Allen, R T; Turner, N J; Jiang, Y

Amine dehydrogenases: Current status and potential value for chiral amine synthesis (Journal Article)

Chem Catalysis, 2 (16), pp. 1288-1314, 2022.

(Links | BibTeX)

Lubberink, M; Finnigan, W; Schnepel, C; Baldwin, C R; Turner, N J; Flitsch, S L

One‐Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation (Journal Article)

Angewandte Chemie International Edition, 61 (30), pp. e202205054, 2022.

(Links | BibTeX)

Aleku, G A; Titchiner, G R; Roberts, G W; Derrington, S R; Marshall, J R; Hollfelder, F; Turner, N J; Leys, D

Enzymatic N-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases (Journal Article)

ACS Sustainable Chemistry & Engineering, 10 (20), pp. 6794–6806, 2022.

(Links | BibTeX)

Büchler, J; Malca, S H; Patsch, D; Voss, M; Turner, N J; Bornscheuer, U T; Allemann, O; Chapelain, Le C; Lumbroso, A; Loiseleur, O; Buller, R

Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens (Journal Article)

Nature Communications, 13 (1), 2022.

(Links | BibTeX)

Thorpe, T W; Marshall, J R; Harawa, V; Ruscoe, R E; Cuetos, A; Finnigan, J D; Angelastro, A; Heath, R S; Parmeggiani, F; Charnock, S J; Howard, R M; Kumar, R; Daniels, D S B; Grogan, G; Turner, N J

Multifunctional biocatalyst for conjugate reduction and reductive amination (Journal Article)

Nature, 604 (7904), pp. 86-91, 2022.

(Links | BibTeX)

Heath, R S; Sangster, J J; Turner, N J

An Engineered Cholesterol Oxidase Catalyses Enantioselective Oxidation of Non-steroidal Secondary Alcohols (Journal Article)

ChemBioChem, 23 (7), 2022.

(Links | BibTeX)

Sangster, J J; Marshall, J R; Turner, N J; Mangas-Sanchez, J

New Trends and Future Opportunities in the Enzymatic Formation of C−C, C−N, and C−O bonds (Journal Article)

ChemBioChem, 23 (6), 2022.

(Links | BibTeX)

Burke, A J; Birmingham, W R; Zhuo, Y; Thorpe, T W; da Costa, Zucoloto B; Crawshaw, R; Rowles, I; Finnigan, J D; Young, C; Holgate, G M; Muldowney, M P; Charnock, S J; Lovelock, S L; Turner, N J; Green, A P

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir (Journal Article)

Journal of the American Chemical Society, 144 (9), pp. 3761-3765, 2022.

(Links | BibTeX)

Galman, J L; Parmeggiani, F; Seibt, L; Birmingham, W R; Turner, N J

One-Pot Biocatalytic In Vivo Methylation-Hydroamination of Bioderived Lignin Monomers to Generate a Key Precursor to L-DOPA (Journal Article)

Angewandte Chemie - International Edition, 61 (8), 2022.

(Links | BibTeX)

Heath, R S; Ruscoe, R E; Turner, N J

The beauty of biocatalysis: Sustainable synthesis of ingredients in cosmetics (Journal Article)

Natural Product Reports, 39 (2), pp. 335-388, 2022.

(Links | BibTeX)

Citoler, J; Finnigan, W; Bevinakatti, H; Turner, N J

Direct Enzymatic Synthesis of Fatty Amines from Renewable Triglycerides and Oils (Journal Article)

ChemBioChem, 23 (2), 2022.

(Links | BibTeX)

Kong, W; Liu, Y; Huang, C; Zhou, L; Gao, J; Turner, N J; Jiang, Y

Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase (Journal Article)

Angewandte Chemie - International Edition, 2022.

(Links | BibTeX)

Peñafiel, I; Dryfe, R A W; Turner, N J; Greaney, M F

Integrated Electro-Biocatalysis for Amine Alkylation with Alcohols (Journal Article)

ChemCatChem, 13 (3), pp. 864-867, 2021.

(Links | BibTeX)

Marshall, J R; Yao, P; Montgomery, S L; Finnigan, J D; Thorpe, T W; Palmer, R B; Mangas-Sanchez, J; Duncan, R A M; Heath, R S; Graham, K M; Cook, D J; Charnock, S J; Turner, N J

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination (Journal Article)

Nature Chemistry, 13 (2), pp. 140-148, 2021.

(Links | BibTeX)

Marshall, J R; Mangas-Sanchez, J; Turner, N J

Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering (Journal Article)

Tetrahedron, 2021.

(Links | BibTeX)

Finnigan, W; Hepworth, L J; Flitsch, S L; Turner, N J

RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades (Journal Article)

Nature Catalysis, 2021.

(Links | BibTeX)

Yao, P; Marshall, J R; Xu, Z; Lim, J; Charnock, S J; Zhu, D; Turner, N J

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination (Journal Article)

Angewandte Chemie - International Edition, 60 (16), pp. 8717-8721, 2021.

(Links | BibTeX)

Birmingham, W R; Pedersen, Toftgaard A; Gomes, Dias M; Madsen, Bøje M; Breuer, M; Woodley, J M; Turner, N J

Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering (Journal Article)

Nature Communications, 12 (1), 2021.

(Links | BibTeX)

Mattey, A P; Ford, G J; Citoler, J; Baldwin, C; Marshall, J R; Palmer, R B; Thompson, M; Turner, N J; Cosgrove, S C; Flitsch, S L

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades** (Journal Article)

Angewandte Chemie - International Edition, 60 (34), pp. 18660-18665, 2021.

(Links | BibTeX)

Romero, E; Jones, B S; Hogg, B N; Casamajo, Rué A; Hayes, M A; Flitsch, S L; Turner, N J; Schnepel, C

Enzymatic Late-Stage Modifications: Better Late Than Never (Journal Article)

Angewandte Chemie - International Edition, 60 (31), pp. 16824-16855, 2021.

(Links | BibTeX)

Roberts, A D; Payne, K A P; Cosgrove, S; Tilakaratna, V; Penafiel, I; Finnigan, W; Turner, N J; Scrutton, N S

Enzyme immobilisation on wood-derived cellulose scaffoldsviacarbohydrate-binding module fusion constructs (Journal Article)

Green Chemistry, 23 (13), pp. 4716-4732, 2021.

(Links | BibTeX)

Wan, L; Heath, R S; Megarity, C F; Sills, A J; Herold, R A; Turner, N J; Armstrong, F A

Exploiting Bidirectional Electrocatalysis by a Nanoconfined Enzyme Cascade to Drive and Control Enantioselective Reactions (Journal Article)

ACS Catalysis, 11 , pp. 6526-6533, 2021.

(Links | BibTeX)

Kimber, R L; Parmeggiani, F; Neill, T S; Merroun, M L; Goodlet, G; Powell, N A; Turner, N J; Lloyd, J R

Biotechnological synthesis of Pd/Ag and Pd/Au nanoparticles for enhanced Suzuki–Miyaura cross-coupling activity (Journal Article)

Microbial Biotechnology, 2021.

(Links | BibTeX)

Citoler, J; Harawa, V; Marshall, J R; Bevinakatti, H; Finnigan, J D; Charnock, S J; Turner, N J

Synthesis of Pharmaceutically Relevant 2-Aminotetralin and 3-Aminochroman Derivatives via Enzymatic Reductive Amination (Journal Article)

Angewandte Chemie - International Edition, 60 (46), pp. 24456-24460, 2021.

(Links | BibTeX)

Mattey, A P; Ford, G J; Citoler, J; Baldwin, C; Marshall, J R; Palmer, R B; Thompson, M; Turner, N J; Cosgrove, S C; Flitsch, S L

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades** (Journal Article)

Angewandte Chemie - International Edition, 60 (34), pp. 18660-18665, 2021.

(Links | BibTeX)

Weise, N J; Thapa, P; Ahmed, S T; Heath, R S; Parmeggiani, F; Turner, N J; Flitsch, S L

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines (Journal Article)

ChemCatChem, 2020.

(Links | BibTeX)

Tramontina, R; Galman, J L; Parmeggiani, F; Derrington, S R; Bugg, T D H; Turner, N J; Squina, F M; Dixon, N

Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass (Journal Article)

Green Chemistry, 22 (1), pp. 144-152, 2020.

(Links | BibTeX)

Mattey, Ashley P; Sangster, Jack J; Ramsden, Jeremy I; Baldwin, Christopher; Birmingham, William R; Heath, Rachel S; Angelastro, Antonio; Turner, Nicholas J; Cosgrove, Sebastian C; Flitsch, Sabine L

Natural heterogeneous catalysis with immobilised oxidase biocatalysts (Journal Article)

RSC Adv., 10 , pp. 19501-19505, 2020.

(Links | BibTeX)

Mangas-Sanchez, Juan; Sharma, Mahima; Cosgrove, Sebastian C; Ramsden, Jeremy I; Marshall, James R; Thorpe, Thomas W; Palmer, Ryan B; Grogan, Gideon; Turner, Nicholas J

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases (Journal Article)

Chem. Sci., 11 , pp. 5052-5057, 2020.

(Links | BibTeX)

Robinson, C J; Carbonell, P; Jervis, A J; Yan, C; Hollywood, K A; Dunstan, M S; Currin, A; Swainston, N; Spiess, R; Taylor, S; Mulherin, P; Parker, S; Rowe, W; Matthews, N E; Malone, K J; Feuvre, Le R; Shapira, P; Barran, P; Turner, N J; Micklefield, J; Breitling, R; Takano, E; Scrutton, N S

Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers (Journal Article)

Metabolic Engineering, 60 , pp. 168-182, 2020.

(Links | BibTeX)

Valverde, P; Vendeville, J -B; Hollingsworth, K; Mattey, A P; Keenan, T; Chidwick, H; Ledru, H; Huonnic, K; Huang, K; Light, M E; Turner, N; Jiménez-Barbero, J; Galan, M C; Fascione, M A; Flitsch, S; Turnbull, W B; Linclau, B

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates (Journal Article)

Chemical Communications, 56 (47), pp. 6408-6411, 2020.

(Links | BibTeX)

Zhao, F; Masci, D; Ferla, S; Varricchio, C; Brancale, A; Colonna, S; Black, G W; Turner, N J; Castagnolo, D

Monoamine Oxidase (MAO-N) Biocatalyzed Synthesis of Indoles from Indolines Prepared via Photocatalytic Cyclization/Arylative Dearomatization (Journal Article)

ACS Catalysis, 10 (11), pp. 6414-6421, 2020.

(Links | BibTeX)

Montgomery, S L; Pushpanath, A; Heath, R S; Marshall, J R; Klemstein, U; Galman, J L; Woodlock, D; Bisagni, S; Taylor, C J; Mangas-Sanchez, J; Ramsden, J I; Dominguez, B; Turner, N J

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships (Journal Article)

Science advances, 6 (21), pp. eaay9320, 2020.

(Links | BibTeX)

Ruscoe, Rebecca E; Ramsden, Jeremy I; Turner, Nicholas J

Redox surrogate methods for sustainable amine N-alkylation (Journal Article)

Current Opinion in Chemical Engineering, 30 , pp. 60 - 68, 2020, ISSN: 2211-3398.

(Abstract | Links | BibTeX)

Ramsden, Jeremy I; Cosgrove, Sebastian C; Turner, Nicholas J

Is it time for biocatalysis in fragment-based drug discovery? (Journal Article)

Chem. Sci., pp. -, 2020.

(Abstract | Links | BibTeX)

Yuan, B; Debecker, D P; Wu, X; Xiao, J; Fei, Q; Turner, N J

One-pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation (Journal Article)

ChemCatChem, 12 (24), pp. 6191-6195, 2020.

(Links | BibTeX)

Çakar, M M; Ruupunen, J; Mangas-Sanchez, J; Birmingham, W R; Yildirim, D; Turunen, O; Turner, N J; Valjakka, J; Binay, B

Engineered formate dehydrogenase from Chaetomium thermophilum, a promising enzymatic solution for biotechnical CO2 fixation (Journal Article)

Biotechnology Letters, 42 (11), pp. 2251-2262, 2020.

(Links | BibTeX)

Finnigan, W; Citoler, J; Cosgrove, S C; Turner, N J

Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow (Journal Article)

Organic Process Research and Development, 24 (10), pp. 1969-1977, 2020.

(Links | BibTeX)

Ford, G J; Kress, N; Mattey, A P; Hepworth, L J; Baldwin, C R; Marshall, J R; Seibt, L S; Huang, M; Birmingham, W R; Turner, N J; Flitsch, S L

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades (Journal Article)

Chemical Communications, 56 (57), pp. 7949-7952, 2020.

(Links | BibTeX)

Cosgrove, Sebastian C; Thompson, Matthew P; Ahmed, Syed T; Parmeggiani, Fabio; Turner, Nicholas J

One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald–Hartwig N-Arylation (Journal Article)

Angewandte Chemie International Edition, n/a (n/a), 2020.

(Links | BibTeX)

Lubberink, Max ; Schnepel, Christian ; Citoler, Joan ; Derrington Sasha R., ; Finigan, William ; Hayes, Martin A; Turner, Nicholas J; Flitsch, Sabine L

Biocatalytic Monoacylation of Symmetrical Diamines and Its Application to the Synthesis of Pharmaceutically Relevant Amides (Journal Article)

ACS Catalysis, 10 (17), pp. 10005-10009 , 2020.

(Links | BibTeX)

Kempa, Emily E; Smith, Clive A; Li, Xin ; Bellina, Bruno ; Rihcardson, Keith ; Pringle, Steven ; Galman, James L; Turner, Nicholas J; Barran, Perdiata E

Coupling Droplet Microfluidics with Mass Spectrometry for Ultrahigh-Throughput Analysis of Complex Mixtures up to and above 30 Hz (Journal Article)

Analytical Chemistry, 92 (18), pp. 12605-12612, 2020.

(Links | BibTeX)

Thompson, M P; Derrington, S R; Heath, R S; Porter, J L; Mangas-Sanchez, J; Devine, P N; Truppo, M D; Turner, N J

A generic platform for the immobilisation of engineered biocatalysts (Journal Article)

Tetrahedron, 75 (3), pp. 327-334, 2019.

(Links | BibTeX)

Heath, R S; Birmingham, W R; Thompson, M P; Taglieber, A; Daviet, L; Turner, N J

An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols (Journal Article)

ChemBioChem, 20 (2), pp. 276-281, 2019.

(Links | BibTeX)

Thompson, M P; Peñafiel, I; Cosgrove, S C; Turner, N J

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals (Journal Article)

Organic Process Research and Development, 23 (1), pp. 9-18, 2019.

(Links | BibTeX)

Ramsden, J I; Heath, R S; Derrington, S R; Montgomery, S L; Mangas-Sanchez, J; Mulholland, K R; Turner, N J

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades (Journal Article)

Journal of the American Chemical Society, 141 (3), pp. 1201-1206, 2019.

(Links | BibTeX)

Megarity, C F; Siritanaratkul, B; Heath, R S; Wan, L; Morello, G; FitzPatrick, S R; Booth, R L; Sills, A J; Robertson, A W; Warner, J H; Turner, N J; Armstrong, F A

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores (Journal Article)

Angewandte Chemie - International Edition, 58 (15), pp. 4948-4952, 2019.

(Links | BibTeX)

Manning, J; Tavanti, M; Porter, J L; Kress, N; Visser, De S P; Turner, N J; Flitsch, S L

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S)-δ-Decalactone (Journal Article)

Angewandte Chemie - International Edition, 58 (17), pp. 5668-5671, 2019.

(Links | BibTeX)

Parmeggiani, F; Casamajo, Rué A; Walton, C J W; Galman, J L; Turner, N J; Chica, R A

One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase (Journal Article)

ACS Catalysis, 9 (4), pp. 3482-3486, 2019.

(Links | BibTeX)

Faber, K; Fessner, W -D; Turner, N J

Biocatalysis: Ready to Master Increasing Complexity (Journal Article)

Advanced Synthesis and Catalysis, 361 (11), pp. 2373-2376, 2019.

(Links | BibTeX)

Bornadel, A; Bisagni, S; Pushpanath, A; Montgomery, S L; Turner, N J; Dominguez, B

Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study (Journal Article)

Organic Process Research and Development, 23 (6), pp. 1262-1268, 2019.

(Links | BibTeX)

Currin, A; Kwok, J; Sadler, J C; Bell, E L; Swainston, N; Ababi, M; Day, P; Turner, N J; Kell, D B

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries (Journal Article)

ACS Synthetic Biology, 8 (6), pp. 1371-1378, 2019.

(Links | BibTeX)

Kimber, Richard L; Parmeggiani, Fabio; Joshi, Nimisha; Rakowski, Alexander M; Haigh, Sarah J; Turner, Nicholas J; Lloyd, Jonathan R

Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles (Journal Article)

Green Chem., 21 (15), pp. 4020-4024, 2019.

(Abstract | Links | BibTeX)

Parmeggiani, Fabio; Casamajo, Arnau Rué; Colombo, Danilo; Ghezzi, Maria Chiara; Galman, James Louis; Chica, Roberto A; Brenna, Elisabetta; Turner, Nicholas J

Biocatalytic retrosynthesis approaches to D-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin (Journal Article)

Green Chem., 21 (16), pp. 4368-4379, 2019.

(Links | BibTeX)

Mourelle-Insua, Ángela; Méndez-Sánchez, Daniel; Galman, James L; Slabu, Iustina; Turner, Nicholas J; Gotor-Fernández, Vicente; Lavandera, Iván

Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions (Journal Article)

Catal. Sci. Technol., 9 (15), pp. 4083-4090, 2019.

(Links | BibTeX)

Derrington, S R; Turner, N J; France, S P

Carboxylic acid reductases (CARs): An industrial perspective (Journal Article)

Journal of Biotechnology, 304 , pp. 78-88, 2019.

(Links | BibTeX)

Wan, Lei; Heath, Rachel S; Siritanaratkul, Bhavin; Megarity, Clare F; Sills, Adam J; Thompson, Matthew P; Turner, Nicholas J; Armstrong, Fraser A

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores (Journal Article)

Green Chem., 21 (18), pp. 4958-4963, 2019.

(Links | BibTeX)

Schnepel, C; Turner, N J

Identifying an iodinase (Journal Article)

Nature Chemistry, 11 (12), pp. 1076-1078, 2019.

(Links | BibTeX)

Hartley, C J; Williams, C C; Scoble, J A; Churches, Q I; North, A; French, N G; Nebl, T; Coia, G; Warden, A C; Simpson, G; Frazer, A R; Jensen, C N; Turner, N J; Scott, C

Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis (Journal Article)

Nature Catalysis, 2 (11), pp. 1006-1015, 2019.

(Links | BibTeX)

Mattey, A P; Birmingham, W R; Both, P; Kress, N; Huang, K; Munster, Van J M; Bulmer, G S; Parmeggiani, F; Voglmeir, J; Martinez, J E R; Turner, N J; Flitsch, S L

Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant (Journal Article)

ACS Catalysis, 9 (9), pp. 8208-8212, 2019.

(Links | BibTeX)

Lauder, Kate; Masci, Domiziana; Toscani, Anita; Mekdad, Aya Al; Black, Gary W; Brown, Nicola L; Turner, Nicholas J; Luisi, Renzo; Castagnolo, Daniele

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution (Journal Article)

Org. Biomol. Chem., 17 , pp. 8982-8986, 2019.

(Abstract | Links | BibTeX)

Thorpe, T W; France, S P; Hussain, S; Marshall, J R; Zawodny, W; Mangas-Sanchez, J; Montgomery, S L; Howard, R M; Daniels, D S B; Kumar, R; Parmeggiani, F; Turner, N J

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles (Journal Article)

Journal of the American Chemical Society, 141 (49), pp. 19208-19213, 2019.

(Links | BibTeX)

Chen, F -F; Cosgrove, S C; Birmingham, W R; Mangas-Sanchez, J; Citoler, J; Thompson, M P; Zheng, G -W; Xu, J -H; Turner, N J

Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases (Journal Article)

ACS Catalysis, 9 (12), pp. 11813-11818, 2019.

(Links | BibTeX)

Citoler, Joan; Derrington, Sasha R; Galman, James L; Bevinakatti, Han; Turner, Nicholas J

A biocatalytic cascade for the conversion of fatty acids to fatty amines (Journal Article)

Green Chem., 21 , pp. 4932-4935, 2019.

(Links | BibTeX)

Cosgrove, S C; Mattey, A P; Riese, M; Chapman, M R; Birmingham, W R; Blacker, A J; Kapur, N; Turner, N J; Flitsch, S L

Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes (Journal Article)

ACS Catalysis, 9 (12), pp. 11658-11662, 2019.

(Links | BibTeX)

Odachowski, M; Greaney, M F; Turner, N J

Concurrent Biocatalytic Oxidation and C-C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines (Journal Article)

ACS Catalysis, 8 (11), pp. 10032-10035, 2018.

(Links | BibTeX)

Costa, B Z; Galman, J L; Slabu, I; France, S P; Marsaioli, A J; Turner, N J

Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts (Journal Article)

ChemCatChem, 10 (20), pp. 4733-4738, 2018.

(Links | BibTeX)

Toscani, A; Risi, C; Black, G W; Brown, N L; Shaaban, A; Turner, N J; Castagnolo, D

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines (Journal Article)

ACS Catalysis, 8 (9), pp. 8781-8787, 2018.

(Links | BibTeX)

Turner, N J

Enzymes team up with light-activated catalysts (Journal Article)

Nature, 560 (7718), pp. 310-311, 2018.

(Links | BibTeX)

Chapman, M R; Cosgrove, S C; Turner, N J; Kapur, N; Blacker, A J

Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen (Journal Article)

Angewandte Chemie - International Edition, 57 (33), pp. 10535-10539, 2018.

(Links | BibTeX)

Tavanti, M; Porter, J L; Levy, C W; Castellanos, Gómez J R; Flitsch, S L; Turner, N J

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s (Journal Article)

Biochemical and Biophysical Research Communications, 501 (4), pp. 846-850, 2018.

(Links | BibTeX)

Carbonell, P; Wong, J; Swainston, N; Takano, E; Turner, N J; Scrutton, N S; Kell, D B; Breitling, R; Faulon, J -L

Selenzyme: Enzyme selection tool for pathway design (Journal Article)

Bioinformatics, 34 (12), pp. 2153-2154, 2018.

(Links | BibTeX)

Cosgrove, S C; Hussain, S; Turner, N J; Marsden, S P

Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines (Journal Article)

ACS Catalysis, 8 (6), pp. 5570-5573, 2018.

(Links | BibTeX)

Porter, J L; Sabatini, S; Manning, J; Tavanti, M; Galman, J L; Turner, N J; Flitsch, S L

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope (Journal Article)

Enzyme and Microbial Technology, 113 , pp. 1-8, 2018.

(Links | BibTeX)

Slabu, I; Galman, J L; Iglesias, C; Weise, N J; Lloyd, R C; Turner, N J

n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones (Journal Article)

Catalysis Today, 306 , pp. 96-101, 2018.

(Links | BibTeX)

Birmingham, W R; Turner, N J

A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase (Journal Article)

ACS Catalysis, 8 (5), pp. 4025-4032, 2018.

(Links | BibTeX)

Çakar, M M; Mangas-Sanchez, J; Birmingham, W R; Turner, N J; Binay, B

Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii (Journal Article)

Preparative Biochemistry and Biotechnology, 48 (4), pp. 327-334, 2018.

(Links | BibTeX)

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Engineered ammonia lyases for the production of challenging electron-rich l -phenylalanines (Journal Article)

ACS Catalysis, 8 (4), pp. 3129-3132, 2018.

(Links | BibTeX)

Turner, N J; Kumar, R

Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis (Journal Article)

Current Opinion in Chemical Biology, 43 , pp. A1-A3, 2018.

(Links | BibTeX)

Weise, N J; Parmeggiani, F; Ahmed, S T; Turner, N J

Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis (Journal Article)

Topics in Catalysis, 61 (3-4), pp. 288-295, 2018.

(Links | BibTeX)

Herter, S; Medina, F; Wagschal, S; Benhaïm, C; Leipold, F; Turner, N J

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines (Journal Article)

Bioorganic and Medicinal Chemistry, 26 (7), pp. 1338-1346, 2018.

(Links | BibTeX)

Morrill, C; Jensen, C; Just-Baringo, X; Grogan, G; Turner, N J; Procter, D J

Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles (Journal Article)

Angewandte Chemie - International Edition, 57 (14), pp. 3692-3696, 2018.

(Links | BibTeX)

Kimber, R L; Lewis, E A; Parmeggiani, F; Smith, K; Bagshaw, H; Starborg, T; Joshi, N; Figueroa, A I; van der Laan, G; Cibin, G; Gianolio, D; Haigh, S J; Pattrick, R A D; Turner, N J; Lloyd, J R

Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry (Journal Article)

Small, 14 (10), 2018.

(Links | BibTeX)

Tavanti, M; Porter, J L; Sabatini, S; Turner, N J; Flitsch, S L

Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope (Journal Article)

ChemCatChem, 10 (5), pp. 1042-1051, 2018.

(Links | BibTeX)

Porter, J L; Manning, J; Sabatini, S; Tavanti, M; Turner, N J; Flitsch, S L

Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids (Journal Article)

ChemBioChem, 19 (5), pp. 513-520, 2018.

(Links | BibTeX)

Barley, M H; Turner, N J; Goodacre, R

Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins (Journal Article)

Journal of Chemical Information and Modeling, 58 (2), pp. 234-243, 2018.

(Links | BibTeX)

France, S P; Howard, R M; Steflik, J; Weise, N J; Mangas-Sanchez, J; Montgomery, S L; Crook, R; Kumar, R; Turner, N J

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination (Journal Article)

ChemCatChem, 10 (3), pp. 510-514, 2018.

(Links | BibTeX)

Aleku, G A; Mangas-Sanchez, J; Citoler, J; France, S P; Montgomery, S L; Heath, R S; Thompson, M P; Turner, N J

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase (Journal Article)

ChemCatChem, 10 (3), pp. 515-519, 2018.

(Links | BibTeX)

Walton, C J W; Parmeggiani, F; Barber, J E B; McCann, J L; Turner, N J; Chica, R A

Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades (Journal Article)

ChemCatChem, 10 (2), pp. 470-474, 2018.

(Links | BibTeX)

Hutchings, G J; Catlow, C R; Turner, N J

Providing sustainable catalytic solutions for a rapidly changing world (Journal Article)

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376 (2110), 2018.

(Links | BibTeX)

Aleku, G A; Nowicka, B; Turner, N J

Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones (Journal Article)

ChemCatChem, 10 (1), pp. 124-135, 2018.

(Links | BibTeX)

Galman, J L; Slabu, I; Parmeggiani, F; Turner, N J

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction (Journal Article)

Chemical Communications, 54 (80), pp. 11316-11319, 2018.

(Links | BibTeX)

Parmeggiani, F; Weise, N J; Ahmed, S T; Turner, N J

Synthetic and therapeutic applications of ammonia-lyases and aminomutases (Journal Article)

Chemical Reviews, 118 (1), pp. 73-118, 2018.

(Links | BibTeX)

Klumbys, E; Zebec, Z; Weise, N J; Turner, N J; Scrutton, N S

Bio-derived production of cinnamyl alcohol: Via a three step biocatalytic cascade and metabolic engineering (Journal Article)

Green Chemistry, 20 (3), pp. 658-663, 2018.

(Links | BibTeX)

Markošová, K; Camattari, A; Rosenberg, M; Glieder, A; Turner, N J; Rebroš, M

Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris (Journal Article)

Biotechnology Letters, 40 (1), pp. 127-133, 2018.

(Links | BibTeX)

Sharma, M; Mangas-Sanchez, J; France, S P; Aleku, G A; Montgomery, S L; Ramsden, J I; Turner, N J; Grogan, G

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases (Journal Article)

ACS Catalysis, pp. 11534-11541, 2018.

(Links | BibTeX)

Cosgrove, S C; Brzezniak, A; France, S P; Ramsden, J I; Mangas-Sanchez, J; Montgomery, S L; Heath, R S; Turner, N J

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications (Journal Article)

Methods in Enzymology, 608 , pp. 131-149, 2018.

(Links | BibTeX)

Batista, V F; Galman, J L; Pinto, D C; Silva, A M S; Turner, N J

Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization (Journal Article)

ACS Catalysis, 8 (12), pp. 11889-11907, 2018.

(Links | BibTeX)

Xu, J; Green, A P; Turner, N J

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles (Journal Article)

Angewandte Chemie - International Edition, 57 (51), pp. 16760-16763, 2018.

(Links | BibTeX)

Devine, P N; Howard, R M; Kumar, R; Thompson, M P; Truppo, M D; Turner, N J

Extending the application of biocatalysis to meet the challenges of drug development (Journal Article)

Nature Reviews Chemistry, 2 (12), pp. 409-421, 2018.

(Links | BibTeX)

Zawodny, W; Montgomery, S L; Marshall, J R; Finnigan, J D; Turner, N J; Clayden, J

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement (Journal Article)

Journal of the American Chemical Society, 140 (51), pp. 17872-17877, 2018, (cited By 0).

(Links | BibTeX)

France, S P; Aleku, G A; Sharma, M; Mangas-Sanchez, J; Howard, R M; Steflik, J; Kumar, R; Adams, R W; Slabu, I; Crook, R; Grogan, G; Wallace, T W; Turner, N J

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines (Journal Article)

Angewandte Chemie - International Edition, 56 (49), pp. 15589-15593, 2017.

(Links | BibTeX)

Slabu, I; Galman, J L; Lloyd, R C; Turner, N J

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts (Journal Article)

ACS Catalysis, 7 (12), pp. 8263-8284, 2017.

(Links | BibTeX)

Weise, N J; Ahmed, S T; Parmeggiani, F; Galman, J L; Dunstan, M S; Charnock, S J; Leys, D; Turner, N J

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes (Journal Article)

Scientific Reports, 7 (1), 2017.

(Links | BibTeX)

Fisk, H; Xu, Y; Westley, C; Turner, N J; Micklefield, J; Goodacre, R

From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy (Journal Article)

Analytical Chemistry, 89 (22), pp. 12527-12532, 2017.

(Links | BibTeX)

Wood, A J L; Weise, N J; Frampton, J D; Dunstan, M S; Hollas, M A; Derrington, S R; Lloyd, R C; Quaglia, D; Parmeggiani, F; Leys, D; Turner, N J; Flitsch, S L

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides (Journal Article)

Angewandte Chemie - International Edition, 56 (46), pp. 14498-14501, 2017.

(Links | BibTeX)

Hartley, C J; French, N G; Scoble, J A; Williams, C C; Churches, Q I; Frazer, A R; Taylor, M C; Coia, G; Simpson, G; Turner, N J; Scott, C

Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis (Journal Article)

PLoS ONE, 12 (11), 2017.

(Links | BibTeX)

Thompson, M P; Turner, N J

Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase (Journal Article)

ChemCatChem, 9 (20), pp. 3833-3836, 2017.

(Links | BibTeX)

Aleku, G A; France, S P; Man, H; Mangas-Sanchez, J; Montgomery, S L; Sharma, M; Leipold, F; Hussain, S; Grogan, G; Turner, N J

A reductive aminase from Aspergillus oryzae (Journal Article)

Nature Chemistry, 9 (10), pp. 961-969, 2017.

(Links | BibTeX)

Chapman, M R; Kwan, M H T; King, G; Jolley, K E; Hussain, M; Hussain, S; Salama, I E; Nino, González C; Thompson, L A; Bayana, M E; Clayton, A D; Nguyen, B N; Turner, N J; Kapur, N; Blacker, A J

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times (Journal Article)

Organic Process Research and Development, 21 (9), pp. 1294-1301, 2017.

(Links | BibTeX)

Tavanti, M; Parmeggiani, F; Castellanos, J R G; Mattevi, A; Turner, N J

One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone (Journal Article)

ChemCatChem, 9 (17), pp. 3338-3348, 2017.

(Links | BibTeX)

Ahmed, S T; Weise, N J; Parmeggiani, F; Turner, N J

Applications of phenylalanine ammonia lyases in synthesis: Access to enantiopure arylalanines from laboratory scale to industrial production (Journal Article)

Chimica Oggi/Chemistry Today, 35 (5), pp. 30-33, 2017.

(Links | BibTeX)

Gahloth, D; Dunstan, M S; Quaglia, D; Klumbys, E; Lockhart-Cairns, M P; Hill, A M; Derrington, S R; Scrutton, N S; Turner, N J; Leys, D

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis (Journal Article)

Nature Chemical Biology, 13 (9), pp. 975-981, 2017.

(Links | BibTeX)

Zajkoska, P; Cárdenas-Fernández, M; Lye, G J; Rosenberg, M; Turner, N J; Rebroš, M

Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase (Journal Article)

Journal of Chemical Technology and Biotechnology, 92 (7), pp. 1558-1565, 2017.

(Links | BibTeX)

Barley, M H; Turner, N J; Goodacre, R

Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes (Journal Article)

ChemBioChem, 18 (12), pp. 1087-1097, 2017.

(Links | BibTeX)

Sharma, M; Mangas-Sanchez, J; Turner, N J; Grogan, G

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application (Journal Article)

Advanced Synthesis and Catalysis, 359 (12), pp. 2011-2025, 2017.

(Links | BibTeX)

Weise, N J; Ahmed, S T; Parmeggiani, F; Turner, N J

Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts (Journal Article)

Advanced Synthesis and Catalysis, 359 (9), pp. 1570-1576, 2017.

(Links | BibTeX)

Hepworth, L J; France, S P; Hussain, S; Both, P; Turner, N J; Flitsch, S L

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines (Journal Article)

ACS Catalysis, 7 (4), pp. 2920-2925, 2017.

(Links | BibTeX)

Mangas-Sanchez, J; France, S P; Montgomery, S L; Aleku, G A; Man, H; Sharma, M; Ramsden, J I; Grogan, G; Turner, N J

Imine reductases (IREDs) (Journal Article)

Current Opinion in Chemical Biology, 37 , pp. 19-25, 2017.

(Links | BibTeX)

Klenk, J M; Nebel, B A; Porter, J L; Kulig, J K; Hussain, S A; Richter, S M; Tavanti, M; Turner, N J; Hayes, M A; Hauer, B; Flitsch, S L

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac (Journal Article)

Biotechnology Journal, 12 (3), 2017.

(Links | BibTeX)

Westley, C; Xu, Y; Thilaganathan, B; Carnell, A J; Turner, N J; Goodacre, R

Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method (Journal Article)

Analytical Chemistry, 89 (4), pp. 2472-2477, 2017.

(Links | BibTeX)

Hugentobler, K G; Rasparini, M; Thompson, L A; Jolley, K E; Blacker, A J; Turner, N J

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor (Journal Article)

Organic Process Research and Development, 21 (2), pp. 195-199, 2017.

(Links | BibTeX)

Scalacci, N; Black, G W; Mattedi, G; Brown, N L; Turner, N J; Castagnolo, D

Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles (Journal Article)

ACS Catalysis, 7 (2), pp. 1295-1300, 2017.

(Links | BibTeX)

Yan, C; Parmeggiani, F; Jones, E A; Claude, E; Hussain, S A; Turner, N J; Flitsch, S L; Barran, P E

Real-time screening of biocatalysts in live bacterial colonies (Journal Article)

Journal of the American Chemical Society, 139 (4), pp. 1408-1411, 2017.

(Links | BibTeX)

France, S P; Hepworth, L J; Turner, N J; Flitsch, S L

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways (Journal Article)

ACS Catalysis, 7 (1), pp. 710-724, 2017.

(Links | BibTeX)

Hönig, M; Sondermann, P; Turner, N J; Carreira, E M

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis (Journal Article)

Angewandte Chemie - International Edition, 56 (31), pp. 8942-8973, 2017.

(Links | BibTeX)

Tavanti, M; Mangas-Sanchez, J; Montgomery, S L; Thompson, M P; Turner, N J

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes (Journal Article)

Organic and Biomolecular Chemistry, 15 (46), pp. 9790-9793, 2017.

(Links | BibTeX)

Galman, J L; Slabu, I; Weise, N J; Iglesias, C; Parmeggiani, F; Lloyd, R C; Turner, N J

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases (Journal Article)

Green Chemistry, 19 (2), pp. 361-366, 2017.

(Links | BibTeX)

Weissenborn, M J; Debecker, D P; Golten, S; Linclau, B; Turner, N J; Flitsch, S L

Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors (Journal Article)

Protein and Peptide Letters, 24 (8), pp. 742-746, 2017.

(Links | BibTeX)

Aslan, A S; Valjakka, J; Ruupunen, J; Yildirim, D; Turner, N J; Turunen, O; Binay, B

Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3 -) to formate (Journal Article)

Protein engineering, design & selection : PEDS, 30 (1), pp. 47-55, 2017.

(Links | BibTeX)

Montgomery, S L; Mangas-Sanchez, J; Thompson, M P; Aleku, G A; Dominguez, B; Turner, N J

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing (Journal Article)

Angewandte Chemie - International Edition, 56 (35), pp. 10491-10494, 2017.

(Links | BibTeX)

Westley, C; Fisk, H; Xu, Y; Hollywood, K A; Carnell, A J; Micklefield, J; Turner, N J; Goodacre, R

Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy (Journal Article)

Chemistry - A European Journal, 23 (29), pp. 6983-6987, 2017.

(Links | BibTeX)

McKenna, S M; Mines, P; Law, P; Kovacs-Schreiner, K; Birmingham, W R; Turner, N J; Leimkühler, S; Carnell, A J

The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC) (Journal Article)

Green Chemistry, 19 (19), pp. 4660-4665, 2017.

(Links | BibTeX)

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination (Journal Article)

Organic Letters, 18 (21), pp. 5468-5471, 2016.

(Links | BibTeX)

Oosterwijk, Van N; Willies, S; Hekelaar, J; Scheltinga, Terwisscha Van A C; Turner, N J; Dijkstra, B W

Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases (Journal Article)

Biochemistry, 55 (31), pp. 4422-4431, 2016.

(Links | BibTeX)

Turner, N J

Sustainable catalysis (Journal Article)

Beilstein Journal of Organic Chemistry, 12 , pp. 1778-1779, 2016.

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Markošová, K; Dolejš, I; Stloukal, R; Rios-Solis, L; Rosenberg, M; Micheletti, M; Lye, G J; Turner, N J; Rebroš, M

Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels (Journal Article)

Journal of Molecular Catalysis B: Enzymatic, 129 , pp. 69-74, 2016.

(Links | BibTeX)

Carbonell, P; Currin, A; Dunstan, M; Fellows, D; Jervis, A; Rattray, N J W; Robinson, C J; Swainston, N; Vinaixa, M; Williams, A; Yan, C; Barran, P; Breitling, R; Chen, G G -Q; Faulon, J -L; Goble, C; Goodacre, R; Kell, D B; Feuvre, R L; Micklefield, J; Scrutton, N S; Shapira, P; Takano, E; Turner, N J

SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals (Journal Article)

Biochemical Society Transactions, 44 (3), pp. 675-677, 2016.

(Links | BibTeX)

Westley, C; Xu, Y; Carnell, A J; Turner, N J; Goodacre, R

Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts (Journal Article)

Analytical Chemistry, 88 (11), pp. 5898-5903, 2016.

(Links | BibTeX)

France, S P; Hussain, S; Hill, A M; Hepworth, L J; Howard, R M; Mulholland, K R; Flitsch, S L; Turner, N J

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts (Journal Article)

ACS Catalysis, 6 (6), pp. 3753-3759, 2016.

(Links | BibTeX)

Aleku, G A; Man, H; France, S P; Leipold, F; Hussain, S; Toca-Gonzalez, L; Marchington, R; Hart, S; Turkenburg, J P; Grogan, G; Turner, N J

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis (Journal Article)

ACS Catalysis, 6 (6), pp. 3880-3889, 2016.

(Links | BibTeX)

Aslan, A S; Birmingham, W R; Karagüler, N G; Turner, N J; Binay, B

Semi-Rational Design of Geobacillus stearothermophilus L-Lactate Dehydrogenase to Access Various Chiral α-Hydroxy Acids (Journal Article)

Applied Biochemistry and Biotechnology, 179 (3), pp. 474-484, 2016.

(Links | BibTeX)

Yan, C; Schmidberger, J W; Parmeggiani, F; Hussain, S A; Turner, N J; Flitsch, S L; Barran, P

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry (Journal Article)

Analyst, 141 (8), pp. 2351-2355, 2016.

(Links | BibTeX)

Slabu, I; Galman, J L; Weise, N J; Lloyd, R C; Turner, N J

Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines (Journal Article)

ChemCatChem, 8 (6), pp. 1038-1042, 2016.

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Wells, A S; Wong, J W; Michels, P C; Entwistle, D A; Fandrick, K; Finch, G L; Goswami, A; Lee, H; Mix, S; Moody, T S; Pang, L; Sato, R K; Turner, N J; Watson, T J

Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form (Journal Article)

Organic Process Research and Development, 20 (3), pp. 594-601, 2016.

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Eichler, A; Gricman, Ł; Herter, S; Kelly, P P; Turner, N J; Pleiss, J; Flitsch, S L

Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling (Journal Article)

ChemBioChem, 17 (5), pp. 426-432, 2016.

(Links | BibTeX)

Willies, S C; Galman, J L; Slabu, I; Turner, N J

A stereospecific solid-phase screening assay for colonies expressing both (R)-and (S)-selective Ω-Aminotransferases (Journal Article)

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 374 (2061), 2016.

(Links | BibTeX)

Grogan, G; Turner, N J

InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines (Journal Article)

Chemistry - A European Journal, 22 (6), pp. 1900-1907, 2016.

(Links | BibTeX)

Both, P; Busch, H; Kelly, P P; Mutti, F G; Turner, N J; Flitsch, S L

Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions (Journal Article)

Angewandte Chemie - International Edition, 55 (4), pp. 1511-1513, 2016.

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Heath, R S; Pontini, M; Hussain, S; Turner, N J

Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles (Journal Article)

ChemCatChem, 8 (1), pp. 117-120, 2016.

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Fisk, H; Westley, C; Turner, N J; Goodacre, R

Achieving optimal SERS through enhanced experimental design (Journal Article)

Journal of Raman Spectroscopy, 47 (1), pp. 59-66, 2016.

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Roselló, J M; Staniland, S; Turner, N J; Clayden, J

Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation (Journal Article)

Tetrahedron, 72 (34), pp. 5172-5177, 2016.

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Parmeggiani, F; Ahmed, S T; Weise, N J; Turner, N J

Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes (Journal Article)

Tetrahedron, 72 (46), pp. 7256-7262, 2016.

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Hugentobler, K G; Sharif, H; Rasparini, M; Heath, R S; Turner, N J

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor (Journal Article)

Organic and Biomolecular Chemistry, 14 (34), pp. 8064-8067, 2016.

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