@article{Büchler2022,
title = {Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens},
author = {J Büchler and S H Malca and D Patsch and M Voss and N J Turner and U T Bornscheuer and O Allemann and C Le Chapelain and A Lumbroso and O Loiseleur and R Buller},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123071538&doi=10.1038%2fs41467-022-27999-1&partnerID=40&md5=5ffe67fdf36a122a92e98b06cfddf949},
doi = {10.1038/s41467-022-27999-1},
year = {2022},
date = {2022-01-01},
journal = {Nature Communications},
volume = {13},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Thorpe, T W; Marshall, J R; Harawa, V; Ruscoe, R E; Cuetos, A; Finnigan, J D; Angelastro, A; Heath, R S; Parmeggiani, F; Charnock, S J; Howard, R M; Kumar, R; Daniels, D S B; Grogan, G; Turner, N J
@article{Thorpe202286,
title = {Multifunctional biocatalyst for conjugate reduction and reductive amination},
author = {T W Thorpe and J R Marshall and V Harawa and R E Ruscoe and A Cuetos and J D Finnigan and A Angelastro and R S Heath and F Parmeggiani and S J Charnock and R M Howard and R Kumar and D S B Daniels and G Grogan and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127698357&doi=10.1038%2fs41586-022-04458-x&partnerID=40&md5=505f461855ef35c15d48a3b5db95cd69},
doi = {10.1038/s41586-022-04458-x},
year = {2022},
date = {2022-01-01},
journal = {Nature},
volume = {604},
number = {7904},
pages = {86-91},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Sangster2022,
title = {New Trends and Future Opportunities in the Enzymatic Formation of C−C, C−N, and C−O bonds},
author = {J J Sangster and J R Marshall and N J Turner and J Mangas-Sanchez},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119700725&doi=10.1002%2fcbic.202100464&partnerID=40&md5=c713397a53ed65b4eb358ba6183f7c4e},
doi = {10.1002/cbic.202100464},
year = {2022},
date = {2022-01-01},
journal = {ChemBioChem},
volume = {23},
number = {6},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Burke, A J; Birmingham, W R; Zhuo, Y; Thorpe, T W; da Costa, Zucoloto B; Crawshaw, R; Rowles, I; Finnigan, J D; Young, C; Holgate, G M; Muldowney, M P; Charnock, S J; Lovelock, S L; Turner, N J; Green, A P
@article{Burke20223761,
title = {An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir},
author = {A J Burke and W R Birmingham and Y Zhuo and T W Thorpe and B Zucoloto da Costa and R Crawshaw and I Rowles and J D Finnigan and C Young and G M Holgate and M P Muldowney and S J Charnock and S L Lovelock and N J Turner and A P Green},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126061002&doi=10.1021%2fjacs.1c11048&partnerID=40&md5=ac065cb7b9e599ad2030ddf7a62d2dd0},
doi = {10.1021/jacs.1c11048},
year = {2022},
date = {2022-01-01},
journal = {Journal of the American Chemical Society},
volume = {144},
number = {9},
pages = {3761-3765},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Galman2022,
title = {One-Pot Biocatalytic In Vivo Methylation-Hydroamination of Bioderived Lignin Monomers to Generate a Key Precursor to L-DOPA},
author = {J L Galman and F Parmeggiani and L Seibt and W R Birmingham and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122465771&doi=10.1002%2fanie.202112855&partnerID=40&md5=64c34a62f5798ebf00920bad80b8a977},
doi = {10.1002/anie.202112855},
year = {2022},
date = {2022-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {61},
number = {8},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Heath2022335,
title = {The beauty of biocatalysis: Sustainable synthesis of ingredients in cosmetics},
author = {R S Heath and R E Ruscoe and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125212213&doi=10.1039%2fd1np00027f&partnerID=40&md5=a2c8790e5aa99b4f342099a578364bae},
doi = {10.1039/d1np00027f},
year = {2022},
date = {2022-01-01},
journal = {Natural Product Reports},
volume = {39},
number = {2},
pages = {335-388},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Citoler2022,
title = {Direct Enzymatic Synthesis of Fatty Amines from Renewable Triglycerides and Oils},
author = {J Citoler and W Finnigan and H Bevinakatti and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119677951&doi=10.1002%2fcbic.202100578&partnerID=40&md5=c5e091acbd4c942910159c7c50375dda},
doi = {10.1002/cbic.202100578},
year = {2022},
date = {2022-01-01},
journal = {ChemBioChem},
volume = {23},
number = {2},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Kong2022,
title = {Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase},
author = {W Kong and Y Liu and C Huang and L Zhou and J Gao and N J Turner and Y Jiang},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126863542&doi=10.1002%2fanie.202202264&partnerID=40&md5=ad0fb307565978c35d4dfb414e35472f},
doi = {10.1002/anie.202202264},
year = {2022},
date = {2022-01-01},
journal = {Angewandte Chemie - International Edition},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Peñafiel2021864,
title = {Integrated Electro-Biocatalysis for Amine Alkylation with Alcohols},
author = {I Peñafiel and R A W Dryfe and N J Turner and M F Greaney},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099474018&doi=10.1002%2fcctc.202001757&partnerID=40&md5=8136913cf443b22e6fecaa1e0593cfe4},
doi = {10.1002/cctc.202001757},
year = {2021},
date = {2021-01-01},
journal = {ChemCatChem},
volume = {13},
number = {3},
pages = {864-867},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Marshall, J R; Yao, P; Montgomery, S L; Finnigan, J D; Thorpe, T W; Palmer, R B; Mangas-Sanchez, J; Duncan, R A M; Heath, R S; Graham, K M; Cook, D J; Charnock, S J; Turner, N J
@article{Marshall2021140,
title = {Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination},
author = {J R Marshall and P Yao and S L Montgomery and J D Finnigan and T W Thorpe and R B Palmer and J Mangas-Sanchez and R A M Duncan and R S Heath and K M Graham and D J Cook and S J Charnock and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098498706&doi=10.1038%2fs41557-020-00606-w&partnerID=40&md5=777a3018bd09de4b90b6e9556c0512f6},
doi = {10.1038/s41557-020-00606-w},
year = {2021},
date = {2021-01-01},
journal = {Nature Chemistry},
volume = {13},
number = {2},
pages = {140-148},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Marshall2021b,
title = {Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering},
author = {J R Marshall and J Mangas-Sanchez and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099624948&doi=10.1016%2fj.tet.2021.131926&partnerID=40&md5=38a21bcc739b02408fec38e14345e462},
doi = {10.1016/j.tet.2021.131926},
year = {2021},
date = {2021-01-01},
journal = {Tetrahedron},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Finnigan2021,
title = {RetroBioCat as a computer-aided synthesis planning tool for biocatalytic reactions and cascades},
author = {W Finnigan and L J Hepworth and S L Flitsch and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098784284&doi=10.1038%2fs41929-020-00556-z&partnerID=40&md5=71296ec5fdb41d078d31833d5d97190a},
doi = {10.1038/s41929-020-00556-z},
year = {2021},
date = {2021-01-01},
journal = {Nature Catalysis},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Yao20218717,
title = {Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination},
author = {P Yao and J R Marshall and Z Xu and J Lim and S J Charnock and D Zhu and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102283426&doi=10.1002%2fanie.202016589&partnerID=40&md5=1e8292040b81a86ae825f359e460b30f},
doi = {10.1002/anie.202016589},
year = {2021},
date = {2021-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {60},
number = {16},
pages = {8717-8721},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Birmingham2021,
title = {Toward scalable biocatalytic conversion of 5-hydroxymethylfurfural by galactose oxidase using coordinated reaction and enzyme engineering},
author = {W R Birmingham and A Toftgaard Pedersen and M Dias Gomes and M Bøje Madsen and M Breuer and J M Woodley and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112720227&doi=10.1038%2fs41467-021-25034-3&partnerID=40&md5=adc908e9a46efdaf3f20f6643a363fbd},
doi = {10.1038/s41467-021-25034-3},
year = {2021},
date = {2021-01-01},
journal = {Nature Communications},
volume = {12},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Mattey202118660,
title = {Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**},
author = {A P Mattey and G J Ford and J Citoler and C Baldwin and J R Marshall and R B Palmer and M Thompson and N J Turner and S C Cosgrove and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106019289&doi=10.1002%2fanie.202103805&partnerID=40&md5=6d13d3dbfa0c3670cd5f83dbe96b28c7},
doi = {10.1002/anie.202103805},
year = {2021},
date = {2021-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {60},
number = {34},
pages = {18660-18665},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Romero202116824,
title = {Enzymatic Late-Stage Modifications: Better Late Than Never},
author = {E Romero and B S Jones and B N Hogg and A Rué Casamajo and M A Hayes and S L Flitsch and N J Turner and C Schnepel},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102192715&doi=10.1002%2fanie.202014931&partnerID=40&md5=54168e74c3b853ca26a1d31865cd9c83},
doi = {10.1002/anie.202014931},
year = {2021},
date = {2021-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {60},
number = {31},
pages = {16824-16855},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Roberts20214716,
title = {Enzyme immobilisation on wood-derived cellulose scaffoldsviacarbohydrate-binding module fusion constructs},
author = {A D Roberts and K A P Payne and S Cosgrove and V Tilakaratna and I Penafiel and W Finnigan and N J Turner and N S Scrutton},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111789435&doi=10.1039%2fd1gc01008e&partnerID=40&md5=4cb49ea486d92c017d2fbd71bcd823a8},
doi = {10.1039/d1gc01008e},
year = {2021},
date = {2021-01-01},
journal = {Green Chemistry},
volume = {23},
number = {13},
pages = {4716-4732},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Wan20216526,
title = {Exploiting Bidirectional Electrocatalysis by a Nanoconfined Enzyme Cascade to Drive and Control Enantioselective Reactions},
author = {L Wan and R S Heath and C F Megarity and A J Sills and R A Herold and N J Turner and F A Armstrong},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108220339&doi=10.1021%2facscatal.1c01198&partnerID=40&md5=e9c90086c74b87dee3a602ec6581511d},
doi = {10.1021/acscatal.1c01198},
year = {2021},
date = {2021-01-01},
journal = {ACS Catalysis},
volume = {11},
pages = {6526-6533},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Kimber2021,
title = {Biotechnological synthesis of Pd/Ag and Pd/Au nanoparticles for enhanced Suzuki–Miyaura cross-coupling activity},
author = {R L Kimber and F Parmeggiani and T S Neill and M L Merroun and G Goodlet and N A Powell and N J Turner and J R Lloyd},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102432599&doi=10.1111%2f1751-7915.13762&partnerID=40&md5=5ae607c6ebf4bbfc7b4992f4698dfb98},
doi = {10.1111/1751-7915.13762},
year = {2021},
date = {2021-01-01},
journal = {Microbial Biotechnology},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Citoler202124456,
title = {Synthesis of Pharmaceutically Relevant 2-Aminotetralin and 3-Aminochroman Derivatives via Enzymatic Reductive Amination},
author = {J Citoler and V Harawa and J R Marshall and H Bevinakatti and J D Finnigan and S J Charnock and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116892645&doi=10.1002%2fanie.202110321&partnerID=40&md5=4350935f477792829ab5bbd558b6a196},
doi = {10.1002/anie.202110321},
year = {2021},
date = {2021-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {60},
number = {46},
pages = {24456-24460},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Mattey202118660b,
title = {Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**},
author = {A P Mattey and G J Ford and J Citoler and C Baldwin and J R Marshall and R B Palmer and M Thompson and N J Turner and S C Cosgrove and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106019289&doi=10.1002%2fanie.202103805&partnerID=40&md5=6d13d3dbfa0c3670cd5f83dbe96b28c7},
doi = {10.1002/anie.202103805},
year = {2021},
date = {2021-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {60},
number = {34},
pages = {18660-18665},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise2020,
title = {Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines},
author = {N J Weise and P Thapa and S T Ahmed and R S Heath and F Parmeggiani and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077866108&doi=10.1002%2fcctc.201902128&partnerID=40&md5=4565a7f80e3b53030fd46ace71766557},
doi = {10.1002/cctc.201902128},
year = {2020},
date = {2020-01-01},
journal = {ChemCatChem},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Tramontina2020144,
title = {Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass},
author = {R Tramontina and J L Galman and F Parmeggiani and S R Derrington and T D H Bugg and N J Turner and F M Squina and N Dixon},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077560808&doi=10.1039%2fc9gc02359c&partnerID=40&md5=cc0b5368892e20d885f25d63bd656ca6},
doi = {10.1039/c9gc02359c},
year = {2020},
date = {2020-01-01},
journal = {Green Chemistry},
volume = {22},
number = {1},
pages = {144-152},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mattey, Ashley P; Sangster, Jack J; Ramsden, Jeremy I; Baldwin, Christopher; Birmingham, William R; Heath, Rachel S; Angelastro, Antonio; Turner, Nicholas J; Cosgrove, Sebastian C; Flitsch, Sabine L
@article{D0RA03618H,
title = {Natural heterogeneous catalysis with immobilised oxidase biocatalysts},
author = {Ashley P Mattey and Jack J Sangster and Jeremy I Ramsden and Christopher Baldwin and William R Birmingham and Rachel S Heath and Antonio Angelastro and Nicholas J Turner and Sebastian C Cosgrove and Sabine L Flitsch},
url = {http://dx.doi.org/10.1039/D0RA03618H},
doi = {10.1039/D0RA03618H},
year = {2020},
date = {2020-01-01},
journal = {RSC Adv.},
volume = {10},
pages = {19501-19505},
publisher = {The Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mangas-Sanchez, Juan; Sharma, Mahima; Cosgrove, Sebastian C; Ramsden, Jeremy I; Marshall, James R; Thorpe, Thomas W; Palmer, Ryan B; Grogan, Gideon; Turner, Nicholas J
@article{D0SC02253E,
title = {Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases},
author = {Juan Mangas-Sanchez and Mahima Sharma and Sebastian C Cosgrove and Jeremy I Ramsden and James R Marshall and Thomas W Thorpe and Ryan B Palmer and Gideon Grogan and Nicholas J Turner},
url = {http://dx.doi.org/10.1039/D0SC02253E},
doi = {10.1039/D0SC02253E},
year = {2020},
date = {2020-01-01},
journal = {Chem. Sci.},
volume = {11},
pages = {5052-5057},
publisher = {The Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Robinson2020168,
title = {Rapid prototyping of microbial production strains for the biomanufacture of potential materials monomers},
author = {C J Robinson and P Carbonell and A J Jervis and C Yan and K A Hollywood and M S Dunstan and A Currin and N Swainston and R Spiess and S Taylor and P Mulherin and S Parker and W Rowe and N E Matthews and K J Malone and R Le Feuvre and P Shapira and P Barran and N J Turner and J Micklefield and R Breitling and E Takano and N S Scrutton},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084189429&doi=10.1016%2fj.ymben.2020.04.008&partnerID=40&md5=9941c0e826919c06a3a5c125e799d4b4},
doi = {10.1016/j.ymben.2020.04.008},
year = {2020},
date = {2020-01-01},
journal = {Metabolic Engineering},
volume = {60},
pages = {168-182},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Valverde20206408,
title = {Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates},
author = {P Valverde and J -B Vendeville and K Hollingsworth and A P Mattey and T Keenan and H Chidwick and H Ledru and K Huonnic and K Huang and M E Light and N Turner and J Jiménez-Barbero and M C Galan and M A Fascione and S Flitsch and W B Turnbull and B Linclau},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086328852&doi=10.1039%2fd0cc02209h&partnerID=40&md5=854027120a0616754ca4b5aeb12223cc},
doi = {10.1039/d0cc02209h},
year = {2020},
date = {2020-01-01},
journal = {Chemical Communications},
volume = {56},
number = {47},
pages = {6408-6411},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Zhao20206414,
title = {Monoamine Oxidase (MAO-N) Biocatalyzed Synthesis of Indoles from Indolines Prepared via Photocatalytic Cyclization/Arylative Dearomatization},
author = {F Zhao and D Masci and S Ferla and C Varricchio and A Brancale and S Colonna and G W Black and N J Turner and D Castagnolo},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087442463&doi=10.1021%2facscatal.0c01351&partnerID=40&md5=01b90c2b53cfbb8b412c892ce4cdeaee},
doi = {10.1021/acscatal.0c01351},
year = {2020},
date = {2020-01-01},
journal = {ACS Catalysis},
volume = {10},
number = {11},
pages = {6414-6421},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Montgomery2020eaay9320,
title = {Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships},
author = {S L Montgomery and A Pushpanath and R S Heath and J R Marshall and U Klemstein and J L Galman and D Woodlock and S Bisagni and C J Taylor and J Mangas-Sanchez and J I Ramsden and B Dominguez and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086008046&doi=10.1126%2fsciadv.aay9320&partnerID=40&md5=09e1ef2765411a1a3049723d167efa60},
doi = {10.1126/sciadv.aay9320},
year = {2020},
date = {2020-01-01},
journal = {Science advances},
volume = {6},
number = {21},
pages = {eaay9320},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{RUSCOE202060,
title = {Redox surrogate methods for sustainable amine N-alkylation},
author = {Rebecca E Ruscoe and Jeremy I Ramsden and Nicholas J Turner},
url = {http://www.sciencedirect.com/science/article/pii/S2211339820300514},
doi = {https://doi.org/10.1016/j.coche.2020.08.005},
issn = {2211-3398},
year = {2020},
date = {2020-01-01},
journal = {Current Opinion in Chemical Engineering},
volume = {30},
pages = {60 - 68},
abstract = {The N-alkylation of amines constitutes one of the most widely applied transformations in synthetic chemistry, but established methods often utilise non-renewable feedstocks and must be adapted for a post fossil fuel world. This review is focused on emerging methodologies in which redox surrogate reagents to carbonyl compounds are used which may be more readily sourced from nature. The review considers both chemocatalytic and biocatalytic approaches and considers challenges such as application and the development of sustainable methodology with low carbon impact.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The N-alkylation of amines constitutes one of the most widely applied transformations in synthetic chemistry, but established methods often utilise non-renewable feedstocks and must be adapted for a post fossil fuel world. This review is focused on emerging methodologies in which redox surrogate reagents to carbonyl compounds are used which may be more readily sourced from nature. The review considers both chemocatalytic and biocatalytic approaches and considers challenges such as application and the development of sustainable methodology with low carbon impact.
@article{D0SC04103C,
title = {Is it time for biocatalysis in fragment-based drug discovery?},
author = {Jeremy I Ramsden and Sebastian C Cosgrove and Nicholas J Turner},
url = {http://dx.doi.org/10.1039/D0SC04103C},
doi = {10.1039/D0SC04103C},
year = {2020},
date = {2020-01-01},
journal = {Chem. Sci.},
pages = {-},
publisher = {The Royal Society of Chemistry},
abstract = {The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.
@article{Yuan20206191,
title = {One-pot Chemoenzymatic Deracemisation of Secondary Alcohols Employing Variants of Galactose Oxidase and Transfer Hydrogenation},
author = {B Yuan and D P Debecker and X Wu and J Xiao and Q Fei and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092394184&doi=10.1002%2fcctc.202001191&partnerID=40&md5=2657b62304c422042a2ef935ee538291},
doi = {10.1002/cctc.202001191},
year = {2020},
date = {2020-01-01},
journal = {ChemCatChem},
volume = {12},
number = {24},
pages = {6191-6195},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Çakar20202251,
title = {Engineered formate dehydrogenase from Chaetomium thermophilum, a promising enzymatic solution for biotechnical CO2 fixation},
author = {M M Çakar and J Ruupunen and J Mangas-Sanchez and W R Birmingham and D Yildirim and O Turunen and N J Turner and J Valjakka and B Binay},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086666863&doi=10.1007%2fs10529-020-02937-7&partnerID=40&md5=a294ca679b85a0c266def5ecb01370bd},
doi = {10.1007/s10529-020-02937-7},
year = {2020},
date = {2020-01-01},
journal = {Biotechnology Letters},
volume = {42},
number = {11},
pages = {2251-2262},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Finnigan20201969,
title = {Rapid Model-Based Optimization of a Two-Enzyme System for Continuous Reductive Amination in Flow},
author = {W Finnigan and J Citoler and S C Cosgrove and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096300349&doi=10.1021%2facs.oprd.0c00075&partnerID=40&md5=06eb31864ea5ba47aace16d764245a12},
doi = {10.1021/acs.oprd.0c00075},
year = {2020},
date = {2020-01-01},
journal = {Organic Process Research and Development},
volume = {24},
number = {10},
pages = {1969-1977},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ford20207949,
title = {Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades},
author = {G J Ford and N Kress and A P Mattey and L J Hepworth and C R Baldwin and J R Marshall and L S Seibt and M Huang and W R Birmingham and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088494096&doi=10.1039%2fd0cc02976a&partnerID=40&md5=663155a3363726ccccacc125a81b1fd3},
doi = {10.1039/d0cc02976a},
year = {2020},
date = {2020-01-01},
journal = {Chemical Communications},
volume = {56},
number = {57},
pages = {7949-7952},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{doi:10.1002/anie.202006246b,
title = {One-Pot Synthesis of Chiral N-Arylamines by Combining Biocatalytic Aminations with Buchwald–Hartwig N-Arylation},
author = {Sebastian C Cosgrove and Matthew P Thompson and Syed T Ahmed and Fabio Parmeggiani and Nicholas J Turner},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202006246},
doi = {10.1002/anie.202006246},
year = {2020},
date = {2020-00-00},
journal = {Angewandte Chemie International Edition},
volume = {n/a},
number = {n/a},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lubberink, Max ; Schnepel, Christian ; Citoler, Joan ; Derrington Sasha R., ; Finigan, William ; Hayes, Martin A; Turner, Nicholas J; Flitsch, Sabine L
@article{lubberink,
title = {Biocatalytic Monoacylation of Symmetrical Diamines and Its Application to the Synthesis of Pharmaceutically Relevant Amides},
author = {Lubberink, Max and Schnepel, Christian and Citoler, Joan and Derrington, Sasha R., and Finigan, William and Hayes, Martin A. and Turner, Nicholas J. and Flitsch, Sabine L.},
url = {https://pubs.acs.org/doi/10.1021/acscatal.0c02228},
doi = {10.1021/acscatal.0c02228 },
year = {2020},
date = {2020-00-00},
journal = {ACS Catalysis},
volume = {10},
number = {17},
pages = {10005-10009 },
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Kempa, Emily E; Smith, Clive A; Li, Xin ; Bellina, Bruno ; Rihcardson, Keith ; Pringle, Steven ; Galman, James L; Turner, Nicholas J; Barran, Perdiata E
@article{kempab,
title = {Coupling Droplet Microfluidics with Mass Spectrometry for Ultrahigh-Throughput Analysis of Complex Mixtures up to and above 30 Hz},
author = {Kempa, Emily E. and Smith, Clive A. and Li, Xin and Bellina, Bruno and Rihcardson, Keith and Pringle, Steven and Galman, James L. and Turner, Nicholas J. and Barran, Perdiata E.},
url = {https://doi.org/10.1021/acs.analchem.0c02632},
doi = {10.1021/acs.analchem.0c02632},
year = {2020},
date = {2020-00-00},
journal = {Analytical Chemistry},
volume = {92},
number = {18},
pages = {12605-12612},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Thompson2019327,
title = {A generic platform for the immobilisation of engineered biocatalysts},
author = {M P Thompson and S R Derrington and R S Heath and J L Porter and J Mangas-Sanchez and P N Devine and M D Truppo and N J Turner},
doi = {10.1016/j.tet.2018.12.004},
year = {2019},
date = {2019-01-01},
journal = {Tetrahedron},
volume = {75},
number = {3},
pages = {327-334},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Heath2019276,
title = {An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols},
author = {R S Heath and W R Birmingham and M P Thompson and A Taglieber and L Daviet and N J Turner},
doi = {10.1002/cbic.201800556},
year = {2019},
date = {2019-01-01},
journal = {ChemBioChem},
volume = {20},
number = {2},
pages = {276-281},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Thompson20199,
title = {Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals},
author = {M P Thompson and I Peñafiel and S C Cosgrove and N J Turner},
doi = {10.1021/acs.oprd.8b00305},
year = {2019},
date = {2019-01-01},
journal = {Organic Process Research and Development},
volume = {23},
number = {1},
pages = {9-18},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ramsden20191201,
title = {Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades},
author = {J I Ramsden and R S Heath and S R Derrington and S L Montgomery and J Mangas-Sanchez and K R Mulholland and N J Turner},
doi = {10.1021/jacs.8b11561},
year = {2019},
date = {2019-01-01},
journal = {Journal of the American Chemical Society},
volume = {141},
number = {3},
pages = {1201-1206},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Megarity, C F; Siritanaratkul, B; Heath, R S; Wan, L; Morello, G; FitzPatrick, S R; Booth, R L; Sills, A J; Robertson, A W; Warner, J H; Turner, N J; Armstrong, F A
@article{Megarity20194948,
title = {Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores},
author = {C F Megarity and B Siritanaratkul and R S Heath and L Wan and G Morello and S R FitzPatrick and R L Booth and A J Sills and A W Robertson and J H Warner and N J Turner and F A Armstrong},
doi = {10.1002/anie.201814370},
year = {2019},
date = {2019-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {58},
number = {15},
pages = {4948-4952},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Manning20195668,
title = {Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S)-δ-Decalactone},
author = {J Manning and M Tavanti and J L Porter and N Kress and S P De Visser and N J Turner and S L Flitsch},
doi = {10.1002/anie.201901242},
year = {2019},
date = {2019-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {58},
number = {17},
pages = {5668-5671},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20193482,
title = {One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase},
author = {F Parmeggiani and A Rué Casamajo and C J W Walton and J L Galman and N J Turner and R A Chica},
doi = {10.1021/acscatal.9b00739},
year = {2019},
date = {2019-01-01},
journal = {ACS Catalysis},
volume = {9},
number = {4},
pages = {3482-3486},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Bornadel20191262,
title = {Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study},
author = {A Bornadel and S Bisagni and A Pushpanath and S L Montgomery and N J Turner and B Dominguez},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067690635&doi=10.1021%2facs.oprd.9b00123&partnerID=40&md5=5f146067233716ead0a37d8e75ca2406},
doi = {10.1021/acs.oprd.9b00123},
year = {2019},
date = {2019-01-01},
journal = {Organic Process Research and Development},
volume = {23},
number = {6},
pages = {1262-1268},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Currin20191371,
title = {GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries},
author = {A Currin and J Kwok and J C Sadler and E L Bell and N Swainston and M Ababi and P Day and N J Turner and D B Kell},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067556821&doi=10.1021%2facssynbio.9b00063&partnerID=40&md5=231ddfa9749bcdc560c28ee714e096a2},
doi = {10.1021/acssynbio.9b00063},
year = {2019},
date = {2019-01-01},
journal = {ACS Synthetic Biology},
volume = {8},
number = {6},
pages = {1371-1378},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{C9GC00270Gb,
title = {Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles},
author = {Richard L Kimber and Fabio Parmeggiani and Nimisha Joshi and Alexander M Rakowski and Sarah J Haigh and Nicholas J Turner and Jonathan R Lloyd},
url = {http://dx.doi.org/10.1039/C9GC00270G},
doi = {10.1039/C9GC00270G},
year = {2019},
date = {2019-01-01},
journal = {Green Chem.},
volume = {21},
number = {15},
pages = {4020-4024},
publisher = {The Royal Society of Chemistry},
abstract = {Copper recovered from a whisky distillery waste stream is shown to be an effective catalyst for a range of azide–alkyne “click” reactions. Biogenic nanomagnetite (BNM), produced under mild conditions, was used to rapidly recover and subsequently support the Cu catalyst which could be separated and recycled easily.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Copper recovered from a whisky distillery waste stream is shown to be an effective catalyst for a range of azide–alkyne “click” reactions. Biogenic nanomagnetite (BNM), produced under mild conditions, was used to rapidly recover and subsequently support the Cu catalyst which could be separated and recycled easily.
@article{C9GC01902B,
title = {Biocatalytic retrosynthesis approaches to D-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin},
author = {Fabio Parmeggiani and Arnau Rué Casamajo and Danilo Colombo and Maria Chiara Ghezzi and James Louis Galman and Roberto A Chica and Elisabetta Brenna and Nicholas J Turner},
url = {http://dx.doi.org/10.1039/C9GC01902B},
doi = {10.1039/C9GC01902B},
year = {2019},
date = {2019-01-01},
journal = {Green Chem.},
volume = {21},
number = {16},
pages = {4368-4379},
publisher = {The Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{C9CY01004A,
title = {Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions},
author = {Ángela Mourelle-Insua and Daniel Méndez-Sánchez and James L Galman and Iustina Slabu and Nicholas J Turner and Vicente Gotor-Fernández and Iván Lavandera},
url = {http://dx.doi.org/10.1039/C9CY01004A},
doi = {10.1039/C9CY01004A},
year = {2019},
date = {2019-01-01},
journal = {Catal. Sci. Technol.},
volume = {9},
number = {15},
pages = {4083-4090},
publisher = {The Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Derrington201978,
title = {Carboxylic acid reductases (CARs): An industrial perspective},
author = {S R Derrington and N J Turner and S P France},
url = {https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85071340147&doi=10.1016%2fj.jbiotec.2019.08.010&partnerID=40&md5=ea6571a1dcef953c31a326b0d8358b53},
doi = {10.1016/j.jbiotec.2019.08.010},
year = {2019},
date = {2019-01-01},
journal = {Journal of Biotechnology},
volume = {304},
pages = {78-88},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{C9GC01534E,
title = {Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores},
author = {Lei Wan and Rachel S Heath and Bhavin Siritanaratkul and Clare F Megarity and Adam J Sills and Matthew P Thompson and Nicholas J Turner and Fraser A Armstrong},
url = {http://dx.doi.org/10.1039/C9GC01534E},
doi = {10.1039/C9GC01534E},
year = {2019},
date = {2019-01-01},
journal = {Green Chem.},
volume = {21},
number = {18},
pages = {4958-4963},
publisher = {The Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Hartley, C J; Williams, C C; Scoble, J A; Churches, Q I; North, A; French, N G; Nebl, T; Coia, G; Warden, A C; Simpson, G; Frazer, A R; Jensen, C N; Turner, N J; Scott, C
@article{Hartley20191006,
title = {Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis},
author = {C J Hartley and C C Williams and J A Scoble and Q I Churches and A North and N G French and T Nebl and G Coia and A C Warden and G Simpson and A R Frazer and C N Jensen and N J Turner and C Scott},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074362133&doi=10.1038%2fs41929-019-0353-0&partnerID=40&md5=b0d6caabde80a3e03b4b41422ef54708},
doi = {10.1038/s41929-019-0353-0},
year = {2019},
date = {2019-01-01},
journal = {Nature Catalysis},
volume = {2},
number = {11},
pages = {1006-1015},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mattey, A P; Birmingham, W R; Both, P; Kress, N; Huang, K; Munster, Van J M; Bulmer, G S; Parmeggiani, F; Voglmeir, J; Martinez, J E R; Turner, N J; Flitsch, S L
@article{Mattey20198208,
title = {Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant},
author = {A P Mattey and W R Birmingham and P Both and N Kress and K Huang and J M Van Munster and G S Bulmer and F Parmeggiani and J Voglmeir and J E R Martinez and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070793491&doi=10.1021%2facscatal.9b02873&partnerID=40&md5=b57abe7dc8f22d2cd6d260af953635f6},
doi = {10.1021/acscatal.9b02873},
year = {2019},
date = {2019-01-01},
journal = {ACS Catalysis},
volume = {9},
number = {9},
pages = {8208-8212},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{C9OB01962F,
title = {A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution},
author = {Kate Lauder and Domiziana Masci and Anita Toscani and Aya Al Mekdad and Gary W Black and Nicola L Brown and Nicholas J Turner and Renzo Luisi and Daniele Castagnolo},
url = {http://dx.doi.org/10.1039/C9OB01962F},
doi = {10.1039/C9OB01962F},
year = {2019},
date = {2019-01-01},
journal = {Org. Biomol. Chem.},
volume = {17},
pages = {8982-8986},
publisher = {The Royal Society of Chemistry},
abstract = {A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.
Thorpe, T W; France, S P; Hussain, S; Marshall, J R; Zawodny, W; Mangas-Sanchez, J; Montgomery, S L; Howard, R M; Daniels, D S B; Kumar, R; Parmeggiani, F; Turner, N J
@article{Thorpe201919208,
title = {One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles},
author = {T W Thorpe and S P France and S Hussain and J R Marshall and W Zawodny and J Mangas-Sanchez and S L Montgomery and R M Howard and D S B Daniels and R Kumar and F Parmeggiani and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076382930&doi=10.1021%2fjacs.9b10053&partnerID=40&md5=80b8b82592b3e000741ac56d059ac1ae},
doi = {10.1021/jacs.9b10053},
year = {2019},
date = {2019-01-01},
journal = {Journal of the American Chemical Society},
volume = {141},
number = {49},
pages = {19208-19213},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Chen201911813,
title = {Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases},
author = {F -F Chen and S C Cosgrove and W R Birmingham and J Mangas-Sanchez and J Citoler and M P Thompson and G -W Zheng and J -H Xu and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075605247&doi=10.1021%2facscatal.9b03889&partnerID=40&md5=04dd0c04f1fbd9be018a743e45a4591a},
doi = {10.1021/acscatal.9b03889},
year = {2019},
date = {2019-01-01},
journal = {ACS Catalysis},
volume = {9},
number = {12},
pages = {11813-11818},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{C9GC02260K,
title = {A biocatalytic cascade for the conversion of fatty acids to fatty amines},
author = {Joan Citoler and Sasha R Derrington and James L Galman and Han Bevinakatti and Nicholas J Turner},
url = {http://dx.doi.org/10.1039/C9GC02260K},
doi = {10.1039/C9GC02260K},
year = {2019},
date = {2019-01-01},
journal = {Green Chem.},
volume = {21},
pages = {4932-4935},
publisher = {The Royal Society of Chemistry},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Cosgrove201911658,
title = {Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes},
author = {S C Cosgrove and A P Mattey and M Riese and M R Chapman and W R Birmingham and A J Blacker and N Kapur and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075605229&doi=10.1021%2facscatal.9b04819&partnerID=40&md5=a13165e5f26d133ff5155b1a4e212f06},
doi = {10.1021/acscatal.9b04819},
year = {2019},
date = {2019-01-01},
journal = {ACS Catalysis},
volume = {9},
number = {12},
pages = {11658-11662},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Odachowski201810032,
title = {Concurrent Biocatalytic Oxidation and C-C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines},
author = {M Odachowski and M F Greaney and N J Turner},
doi = {10.1021/acscatal.8b03169},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {11},
pages = {10032-10035},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Costa20184733,
title = {Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts},
author = {B Z Costa and J L Galman and I Slabu and S P France and A J Marsaioli and N J Turner},
doi = {10.1002/cctc.201801166},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {20},
pages = {4733-4738},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Toscani20188781,
title = {Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines},
author = {A Toscani and C Risi and G W Black and N L Brown and A Shaaban and N J Turner and D Castagnolo},
doi = {10.1021/acscatal.8b02386},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {9},
pages = {8781-8787},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Chapman201810535,
title = {Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen},
author = {M R Chapman and S C Cosgrove and N J Turner and N Kapur and A J Blacker},
doi = {10.1002/anie.201803675},
year = {2018},
date = {2018-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {57},
number = {33},
pages = {10535-10539},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Tavanti2018846,
title = {The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s},
author = {M Tavanti and J L Porter and C W Levy and J R Gómez Castellanos and S L Flitsch and N J Turner},
doi = {10.1016/j.bbrc.2018.05.014},
year = {2018},
date = {2018-01-01},
journal = {Biochemical and Biophysical Research Communications},
volume = {501},
number = {4},
pages = {846-850},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Carbonell20182153,
title = {Selenzyme: Enzyme selection tool for pathway design},
author = {P Carbonell and J Wong and N Swainston and E Takano and N J Turner and N S Scrutton and D B Kell and R Breitling and J -L Faulon},
doi = {10.1093/bioinformatics/bty065},
year = {2018},
date = {2018-01-01},
journal = {Bioinformatics},
volume = {34},
number = {12},
pages = {2153-2154},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Cosgrove20185570,
title = {Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines},
author = {S C Cosgrove and S Hussain and N J Turner and S P Marsden},
doi = {10.1021/acscatal.8b01220},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {6},
pages = {5570-5573},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Porter20181,
title = {Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope},
author = {J L Porter and S Sabatini and J Manning and M Tavanti and J L Galman and N J Turner and S L Flitsch},
doi = {10.1016/j.enzmictec.2018.02.005},
year = {2018},
date = {2018-01-01},
journal = {Enzyme and Microbial Technology},
volume = {113},
pages = {1-8},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Slabu201896,
title = {n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones},
author = {I Slabu and J L Galman and C Iglesias and N J Weise and R C Lloyd and N J Turner},
doi = {10.1016/j.cattod.2017.01.025},
year = {2018},
date = {2018-01-01},
journal = {Catalysis Today},
volume = {306},
pages = {96-101},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Birmingham20184025,
title = {A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase},
author = {W R Birmingham and N J Turner},
doi = {10.1021/acscatal.8b00043},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {5},
pages = {4025-4032},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Çakar2018327,
title = {Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii},
author = {M M Çakar and J Mangas-Sanchez and W R Birmingham and N J Turner and B Binay},
doi = {10.1080/10826068.2018.1446150},
year = {2018},
date = {2018-01-01},
journal = {Preparative Biochemistry and Biotechnology},
volume = {48},
number = {4},
pages = {327-334},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Ahmed20183129,
title = {Engineered ammonia lyases for the production of challenging electron-rich l -phenylalanines},
author = {S T Ahmed and F Parmeggiani and N J Weise and S L Flitsch and N J Turner},
doi = {10.1021/acscatal.8b00496},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {4},
pages = {3129-3132},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Turner2018A1,
title = {Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis},
author = {N J Turner and R Kumar},
doi = {10.1016/j.cbpa.2018.02.012},
year = {2018},
date = {2018-01-01},
journal = {Current Opinion in Chemical Biology},
volume = {43},
pages = {A1-A3},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Weise2018288,
title = {Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis},
author = {N J Weise and F Parmeggiani and S T Ahmed and N J Turner},
doi = {10.1007/s11244-018-0898-1},
year = {2018},
date = {2018-01-01},
journal = {Topics in Catalysis},
volume = {61},
number = {3-4},
pages = {288-295},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Herter20181338,
title = {Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines},
author = {S Herter and F Medina and S Wagschal and C Benhaïm and F Leipold and N J Turner},
doi = {10.1016/j.bmc.2017.07.023},
year = {2018},
date = {2018-01-01},
journal = {Bioorganic and Medicinal Chemistry},
volume = {26},
number = {7},
pages = {1338-1346},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Morrill20183692,
title = {Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles},
author = {C Morrill and C Jensen and X Just-Baringo and G Grogan and N J Turner and D J Procter},
doi = {10.1002/anie.201800121},
year = {2018},
date = {2018-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {57},
number = {14},
pages = {3692-3696},
keywords = {},
pubstate = {published},
tppubtype = {article}
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Kimber, R L; Lewis, E A; Parmeggiani, F; Smith, K; Bagshaw, H; Starborg, T; Joshi, N; Figueroa, A I; van der Laan, G; Cibin, G; Gianolio, D; Haigh, S J; Pattrick, R A D; Turner, N J; Lloyd, J R
@article{Kimber2018,
title = {Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry},
author = {R L Kimber and E A Lewis and F Parmeggiani and K Smith and H Bagshaw and T Starborg and N Joshi and A I Figueroa and G van der Laan and G Cibin and D Gianolio and S J Haigh and R A D Pattrick and N J Turner and J R Lloyd},
doi = {10.1002/smll.201703145},
year = {2018},
date = {2018-01-01},
journal = {Small},
volume = {14},
number = {10},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Tavanti20181042,
title = {Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope},
author = {M Tavanti and J L Porter and S Sabatini and N J Turner and S L Flitsch},
doi = {10.1002/cctc.201701510},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {5},
pages = {1042-1051},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Porter2018513,
title = {Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids},
author = {J L Porter and J Manning and S Sabatini and M Tavanti and N J Turner and S L Flitsch},
doi = {10.1002/cbic.201700598},
year = {2018},
date = {2018-01-01},
journal = {ChemBioChem},
volume = {19},
number = {5},
pages = {513-520},
keywords = {},
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tppubtype = {article}
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@article{Barley2018234,
title = {Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins},
author = {M H Barley and N J Turner and R Goodacre},
doi = {10.1021/acs.jcim.7b00488},
year = {2018},
date = {2018-01-01},
journal = {Journal of Chemical Information and Modeling},
volume = {58},
number = {2},
pages = {234-243},
keywords = {},
pubstate = {published},
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@article{France2018510,
title = {Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination},
author = {S P France and R M Howard and J Steflik and N J Weise and J Mangas-Sanchez and S L Montgomery and R Crook and R Kumar and N J Turner},
doi = {10.1002/cctc.201701408},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {3},
pages = {510-514},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Aleku2018515,
title = {Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase},
author = {G A Aleku and J Mangas-Sanchez and J Citoler and S P France and S L Montgomery and R S Heath and M P Thompson and N J Turner},
doi = {10.1002/cctc.201701484},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {3},
pages = {515-519},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Walton2018470,
title = {Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades},
author = {C J W Walton and F Parmeggiani and J E B Barber and J L McCann and N J Turner and R A Chica},
doi = {10.1002/cctc.201701068},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {2},
pages = {470-474},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Hutchings2018,
title = {Providing sustainable catalytic solutions for a rapidly changing world},
author = {G J Hutchings and C R Catlow and N J Turner},
doi = {10.1098/rsta.2017.0309},
year = {2018},
date = {2018-01-01},
journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
volume = {376},
number = {2110},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Aleku2018124,
title = {Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones},
author = {G A Aleku and B Nowicka and N J Turner},
doi = {10.1002/cctc.201700685},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {1},
pages = {124-135},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Galman201811316,
title = {Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction},
author = {J L Galman and I Slabu and F Parmeggiani and N J Turner},
doi = {10.1039/C8CC06759G},
year = {2018},
date = {2018-01-01},
journal = {Chemical Communications},
volume = {54},
number = {80},
pages = {11316-11319},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Parmeggiani201873,
title = {Synthetic and therapeutic applications of ammonia-lyases and aminomutases},
author = {F Parmeggiani and N J Weise and S T Ahmed and N J Turner},
doi = {10.1021/acs.chemrev.6b00824},
year = {2018},
date = {2018-01-01},
journal = {Chemical Reviews},
volume = {118},
number = {1},
pages = {73-118},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Klumbys2018658,
title = {Bio-derived production of cinnamyl alcohol: Via a three step biocatalytic cascade and metabolic engineering},
author = {E Klumbys and Z Zebec and N J Weise and N J Turner and N S Scrutton},
doi = {10.1039/c7gc03325g},
year = {2018},
date = {2018-01-01},
journal = {Green Chemistry},
volume = {20},
number = {3},
pages = {658-663},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Markošová2018127,
title = {Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris},
author = {K Markošová and A Camattari and M Rosenberg and A Glieder and N J Turner and M Rebroš},
doi = {10.1007/s10529-017-2450-y},
year = {2018},
date = {2018-01-01},
journal = {Biotechnology Letters},
volume = {40},
number = {1},
pages = {127-133},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Sharma201811534,
title = {A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases},
author = {M Sharma and J Mangas-Sanchez and S P France and G A Aleku and S L Montgomery and J I Ramsden and N J Turner and G Grogan},
doi = {10.1021/acscatal.8b03491},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
pages = {11534-11541},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Cosgrove2018131,
title = {Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications},
author = {S C Cosgrove and A Brzezniak and S P France and J I Ramsden and J Mangas-Sanchez and S L Montgomery and R S Heath and N J Turner},
doi = {10.1016/bs.mie.2018.04.022},
year = {2018},
date = {2018-01-01},
journal = {Methods in Enzymology},
volume = {608},
pages = {131-149},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Batista201811889,
title = {Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization},
author = {V F Batista and J L Galman and D C Pinto and A M S Silva and N J Turner},
doi = {10.1021/acscatal.8b03525},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {12},
pages = {11889-11907},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Xu201816760,
title = {Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles},
author = {J Xu and A P Green and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057010763&doi=10.1002%2fanie.201810555&partnerID=40&md5=a3353cb0471575cf34876f6915950255},
doi = {10.1002/anie.201810555},
year = {2018},
date = {2018-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {57},
number = {51},
pages = {16760-16763},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Devine2018409,
title = {Extending the application of biocatalysis to meet the challenges of drug development},
author = {P N Devine and R M Howard and R Kumar and M P Thompson and M D Truppo and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060102129&doi=10.1038%2fs41570-018-0055-1&partnerID=40&md5=66093a04b19e180f6ca493bbc85c9d76},
doi = {10.1038/s41570-018-0055-1},
year = {2018},
date = {2018-01-01},
journal = {Nature Reviews Chemistry},
volume = {2},
number = {12},
pages = {409-421},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@book{Burke20181,
title = {Active pharmaceutical ingredients in synthesis: Catalytic processes in research and development},
author = {A J Burke and C S Marques and N J Turner and G J Hermann},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060529666&doi=10.1002%2f9783527807253&partnerID=40&md5=885f37990332e0db06c2dc8b78854f82},
doi = {10.1002/9783527807253},
year = {2018},
date = {2018-01-01},
journal = {Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development},
pages = {1-426},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
@article{Zawodny201817872,
title = {Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement},
author = {W Zawodny and S L Montgomery and J R Marshall and J D Finnigan and N J Turner and J Clayden},
doi = {10.1021/jacs.8b11891},
year = {2018},
date = {2018-01-01},
journal = {Journal of the American Chemical Society},
volume = {140},
number = {51},
pages = {17872-17877},
note = {cited By 0},
keywords = {},
pubstate = {published},
tppubtype = {article}
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France, S P; Aleku, G A; Sharma, M; Mangas-Sanchez, J; Howard, R M; Steflik, J; Kumar, R; Adams, R W; Slabu, I; Crook, R; Grogan, G; Wallace, T W; Turner, N J
@article{France201715589,
title = {Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines},
author = {S P France and G A Aleku and M Sharma and J Mangas-Sanchez and R M Howard and J Steflik and R Kumar and R W Adams and I Slabu and R Crook and G Grogan and T W Wallace and N J Turner},
doi = {10.1002/anie.201708453},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {49},
pages = {15589-15593},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Slabu20178263,
title = {Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts},
author = {I Slabu and J L Galman and R C Lloyd and N J Turner},
doi = {10.1021/acscatal.7b02686},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {12},
pages = {8263-8284},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise2017,
title = {Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes},
author = {N J Weise and S T Ahmed and F Parmeggiani and J L Galman and M S Dunstan and S J Charnock and D Leys and N J Turner},
doi = {10.1038/s41598-017-13990-0},
year = {2017},
date = {2017-01-01},
journal = {Scientific Reports},
volume = {7},
number = {1},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Fisk201712527,
title = {From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy},
author = {H Fisk and Y Xu and C Westley and N J Turner and J Micklefield and R Goodacre},
doi = {10.1021/acs.analchem.7b03742},
year = {2017},
date = {2017-01-01},
journal = {Analytical Chemistry},
volume = {89},
number = {22},
pages = {12527-12532},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wood, A J L; Weise, N J; Frampton, J D; Dunstan, M S; Hollas, M A; Derrington, S R; Lloyd, R C; Quaglia, D; Parmeggiani, F; Leys, D; Turner, N J; Flitsch, S L
@article{Wood201714498,
title = {Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides},
author = {A J L Wood and N J Weise and J D Frampton and M S Dunstan and M A Hollas and S R Derrington and R C Lloyd and D Quaglia and F Parmeggiani and D Leys and N J Turner and S L Flitsch},
doi = {10.1002/anie.201707918},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {46},
pages = {14498-14501},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hartley2017,
title = {Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis},
author = {C J Hartley and N G French and J A Scoble and C C Williams and Q I Churches and A R Frazer and M C Taylor and G Coia and G Simpson and N J Turner and C Scott},
doi = {10.1371/journal.pone.0184183},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {11},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Thompson20173833,
title = {Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase},
author = {M P Thompson and N J Turner},
doi = {10.1002/cctc.201701092},
year = {2017},
date = {2017-01-01},
journal = {ChemCatChem},
volume = {9},
number = {20},
pages = {3833-3836},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aleku2017961,
title = {A reductive aminase from Aspergillus oryzae},
author = {G A Aleku and S P France and H Man and J Mangas-Sanchez and S L Montgomery and M Sharma and F Leipold and S Hussain and G Grogan and N J Turner},
doi = {10.1038/nchem.2782},
year = {2017},
date = {2017-01-01},
journal = {Nature Chemistry},
volume = {9},
number = {10},
pages = {961-969},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chapman, M R; Kwan, M H T; King, G; Jolley, K E; Hussain, M; Hussain, S; Salama, I E; Nino, González C; Thompson, L A; Bayana, M E; Clayton, A D; Nguyen, B N; Turner, N J; Kapur, N; Blacker, A J
@article{Chapman20171294,
title = {Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times},
author = {M R Chapman and M H T Kwan and G King and K E Jolley and M Hussain and S Hussain and I E Salama and C González Nino and L A Thompson and M E Bayana and A D Clayton and B N Nguyen and N J Turner and N Kapur and A J Blacker},
doi = {10.1021/acs.oprd.7b00173},
year = {2017},
date = {2017-01-01},
journal = {Organic Process Research and Development},
volume = {21},
number = {9},
pages = {1294-1301},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Tavanti20173338,
title = {One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone},
author = {M Tavanti and F Parmeggiani and J R G Castellanos and A Mattevi and N J Turner},
doi = {10.1002/cctc.201700620},
year = {2017},
date = {2017-01-01},
journal = {ChemCatChem},
volume = {9},
number = {17},
pages = {3338-3348},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Ahmed201730,
title = {Applications of phenylalanine ammonia lyases in synthesis: Access to enantiopure arylalanines from laboratory scale to industrial production},
author = {S T Ahmed and N J Weise and F Parmeggiani and N J Turner},
url = {https://www.teknoscienze.com/tks_article/applications-of-phenylalanine-ammonia-lyases-in-synthesis/},
year = {2017},
date = {2017-01-01},
journal = {Chimica Oggi/Chemistry Today},
volume = {35},
number = {5},
pages = {30-33},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Gahloth2017975,
title = {Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis},
author = {D Gahloth and M S Dunstan and D Quaglia and E Klumbys and M P Lockhart-Cairns and A M Hill and S R Derrington and N S Scrutton and N J Turner and D Leys},
doi = {10.1038/nchembio.2434},
year = {2017},
date = {2017-01-01},
journal = {Nature Chemical Biology},
volume = {13},
number = {9},
pages = {975-981},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Zajkoska20171558,
title = {Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase},
author = {P Zajkoska and M Cárdenas-Fernández and G J Lye and M Rosenberg and N J Turner and M Rebroš},
doi = {10.1002/jctb.5146},
year = {2017},
date = {2017-01-01},
journal = {Journal of Chemical Technology and Biotechnology},
volume = {92},
number = {7},
pages = {1558-1565},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Barley20171087,
title = {Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes},
author = {M H Barley and N J Turner and R Goodacre},
doi = {10.1002/cbic.201700013},
year = {2017},
date = {2017-01-01},
journal = {ChemBioChem},
volume = {18},
number = {12},
pages = {1087-1097},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Sharma20172011,
title = {NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application},
author = {M Sharma and J Mangas-Sanchez and N J Turner and G Grogan},
doi = {10.1002/adsc.201700356},
year = {2017},
date = {2017-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {359},
number = {12},
pages = {2011-2025},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise20171570,
title = {Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts},
author = {N J Weise and S T Ahmed and F Parmeggiani and N J Turner},
doi = {10.1002/adsc.201600894},
year = {2017},
date = {2017-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {359},
number = {9},
pages = {1570-1576},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hepworth20172920,
title = {Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines},
author = {L J Hepworth and S P France and S Hussain and P Both and N J Turner and S L Flitsch},
doi = {10.1021/acscatal.7b00513},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {4},
pages = {2920-2925},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Mangas-Sanchez201719,
title = {Imine reductases (IREDs)},
author = {J Mangas-Sanchez and S P France and S L Montgomery and G A Aleku and H Man and M Sharma and J I Ramsden and G Grogan and N J Turner},
doi = {10.1016/j.cbpa.2016.11.022},
year = {2017},
date = {2017-01-01},
journal = {Current Opinion in Chemical Biology},
volume = {37},
pages = {19-25},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Klenk2017,
title = {The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac},
author = {J M Klenk and B A Nebel and J L Porter and J K Kulig and S A Hussain and S M Richter and M Tavanti and N J Turner and M A Hayes and B Hauer and S L Flitsch},
doi = {10.1002/biot.201600520},
year = {2017},
date = {2017-01-01},
journal = {Biotechnology Journal},
volume = {12},
number = {3},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Westley20172472,
title = {Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method},
author = {C Westley and Y Xu and B Thilaganathan and A J Carnell and N J Turner and R Goodacre},
doi = {10.1021/acs.analchem.6b04588},
year = {2017},
date = {2017-01-01},
journal = {Analytical Chemistry},
volume = {89},
number = {4},
pages = {2472-2477},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Hugentobler2017195,
title = {Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor},
author = {K G Hugentobler and M Rasparini and L A Thompson and K E Jolley and A J Blacker and N J Turner},
doi = {10.1021/acs.oprd.6b00346},
year = {2017},
date = {2017-01-01},
journal = {Organic Process Research and Development},
volume = {21},
number = {2},
pages = {195-199},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Scalacci20171295,
title = {Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles},
author = {N Scalacci and G W Black and G Mattedi and N L Brown and N J Turner and D Castagnolo},
doi = {10.1021/acscatal.6b03081},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {2},
pages = {1295-1300},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Yan20171408,
title = {Real-time screening of biocatalysts in live bacterial colonies},
author = {C Yan and F Parmeggiani and E A Jones and E Claude and S A Hussain and N J Turner and S L Flitsch and P E Barran},
doi = {10.1021/jacs.6b12165},
year = {2017},
date = {2017-01-01},
journal = {Journal of the American Chemical Society},
volume = {139},
number = {4},
pages = {1408-1411},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{France2017710,
title = {Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways},
author = {S P France and L J Hepworth and N J Turner and S L Flitsch},
doi = {10.1021/acscatal.6b02979},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {1},
pages = {710-724},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Hönig20178942,
title = {Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis},
author = {M Hönig and P Sondermann and N J Turner and E M Carreira},
doi = {10.1002/anie.201612462},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {31},
pages = {8942-8973},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Tavanti20179790,
title = {A biocatalytic cascade for the amination of unfunctionalised cycloalkanes},
author = {M Tavanti and J Mangas-Sanchez and S L Montgomery and M P Thompson and N J Turner},
doi = {10.1039/c7ob02569f},
year = {2017},
date = {2017-01-01},
journal = {Organic and Biomolecular Chemistry},
volume = {15},
number = {46},
pages = {9790-9793},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@book{Hutchings20171,
title = {Modern developments in catalysis},
author = {G Hutchings and M Davidson and R Catlow and C Hardacre and N Turner and P Collier},
doi = {10.1142/q0035},
year = {2017},
date = {2017-01-01},
journal = {Modern Developments in Catalysis},
pages = {1-320},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
@article{Galman2017361,
title = {Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases},
author = {J L Galman and I Slabu and N J Weise and C Iglesias and F Parmeggiani and R C Lloyd and N J Turner},
doi = {10.1039/c6gc02102f},
year = {2017},
date = {2017-01-01},
journal = {Green Chemistry},
volume = {19},
number = {2},
pages = {361-366},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Weissenborn2017742,
title = {Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors},
author = {M J Weissenborn and D P Debecker and S Golten and B Linclau and N J Turner and S L Flitsch},
doi = {10.2174/0929866524666170724114348},
year = {2017},
date = {2017-01-01},
journal = {Protein and Peptide Letters},
volume = {24},
number = {8},
pages = {742-746},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Aslan201747,
title = {Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3 -) to formate},
author = {A S Aslan and J Valjakka and J Ruupunen and D Yildirim and N J Turner and O Turunen and B Binay},
doi = {10.1093/protein/gzw062},
year = {2017},
date = {2017-01-01},
journal = {Protein engineering, design & selection : PEDS},
volume = {30},
number = {1},
pages = {47-55},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Montgomery201710491,
title = {Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing},
author = {S L Montgomery and J Mangas-Sanchez and M P Thompson and G A Aleku and B Dominguez and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025447057&doi=10.1002%2fanie.201705848&partnerID=40&md5=eed24e7ae2f636451659a45758dd448d},
doi = {10.1002/anie.201705848},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {35},
pages = {10491-10494},
keywords = {},
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@article{Westley20176983,
title = {Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy},
author = {C Westley and H Fisk and Y Xu and K A Hollywood and A J Carnell and J Micklefield and N J Turner and R Goodacre},
doi = {10.1002/chem.201701388},
year = {2017},
date = {2017-01-01},
journal = {Chemistry - A European Journal},
volume = {23},
number = {29},
pages = {6983-6987},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{McKenna20174660,
title = {The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)},
author = {S M McKenna and P Mines and P Law and K Kovacs-Schreiner and W R Birmingham and N J Turner and S Leimkühler and A J Carnell},
doi = {10.1039/c7gc01696d},
year = {2017},
date = {2017-01-01},
journal = {Green Chemistry},
volume = {19},
number = {19},
pages = {4660-4665},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ahmed20165468,
title = {Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination},
author = {S T Ahmed and F Parmeggiani and N J Weise and S L Flitsch and N J Turner},
doi = {10.1021/acs.orglett.6b02559},
year = {2016},
date = {2016-01-01},
journal = {Organic Letters},
volume = {18},
number = {21},
pages = {5468-5471},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{VanOosterwijk20164422,
title = {Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases},
author = {N Van Oosterwijk and S Willies and J Hekelaar and A C Terwisscha Van Scheltinga and N J Turner and B W Dijkstra},
doi = {10.1021/acs.biochem.6b00370},
year = {2016},
date = {2016-01-01},
journal = {Biochemistry},
volume = {55},
number = {31},
pages = {4422-4431},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Markošová201669,
title = {Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels},
author = {K Markošová and I Dolejš and R Stloukal and L Rios-Solis and M Rosenberg and M Micheletti and G J Lye and N J Turner and M Rebroš},
doi = {10.1016/j.molcatb.2016.04.009},
year = {2016},
date = {2016-01-01},
journal = {Journal of Molecular Catalysis B: Enzymatic},
volume = {129},
pages = {69-74},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Carbonell2016675,
title = {SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals},
author = {P Carbonell and A Currin and M Dunstan and D Fellows and A Jervis and N J W Rattray and C J Robinson and N Swainston and M Vinaixa and A Williams and C Yan and P Barran and R Breitling and G G -Q Chen and J -L Faulon and C Goble and R Goodacre and D B Kell and R L Feuvre and J Micklefield and N S Scrutton and P Shapira and E Takano and N J Turner},
doi = {10.1042/BST20160009},
year = {2016},
date = {2016-01-01},
journal = {Biochemical Society Transactions},
volume = {44},
number = {3},
pages = {675-677},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Westley20165898,
title = {Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts},
author = {C Westley and Y Xu and A J Carnell and N J Turner and R Goodacre},
doi = {10.1021/acs.analchem.6b00813},
year = {2016},
date = {2016-01-01},
journal = {Analytical Chemistry},
volume = {88},
number = {11},
pages = {5898-5903},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{France20163753,
title = {One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts},
author = {S P France and S Hussain and A M Hill and L J Hepworth and R M Howard and K R Mulholland and S L Flitsch and N J Turner},
doi = {10.1021/acscatal.6b00855},
year = {2016},
date = {2016-01-01},
journal = {ACS Catalysis},
volume = {6},
number = {6},
pages = {3753-3759},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aleku20163880,
title = {Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis},
author = {G A Aleku and H Man and S P France and F Leipold and S Hussain and L Toca-Gonzalez and R Marchington and S Hart and J P Turkenburg and G Grogan and N J Turner},
doi = {10.1021/acscatal.6b00782},
year = {2016},
date = {2016-01-01},
journal = {ACS Catalysis},
volume = {6},
number = {6},
pages = {3880-3889},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aslan2016474,
title = {Semi-Rational Design of Geobacillus stearothermophilus L-Lactate Dehydrogenase to Access Various Chiral α-Hydroxy Acids},
author = {A S Aslan and W R Birmingham and N G Karagüler and N J Turner and B Binay},
doi = {10.1007/s12010-016-2007-x},
year = {2016},
date = {2016-01-01},
journal = {Applied Biochemistry and Biotechnology},
volume = {179},
number = {3},
pages = {474-484},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Yan20162351,
title = {Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry},
author = {C Yan and J W Schmidberger and F Parmeggiani and S A Hussain and N J Turner and S L Flitsch and P Barran},
doi = {10.1039/c6an00617e},
year = {2016},
date = {2016-01-01},
journal = {Analyst},
volume = {141},
number = {8},
pages = {2351-2355},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Slabu20161038,
title = {Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines},
author = {I Slabu and J L Galman and N J Weise and R C Lloyd and N J Turner},
doi = {10.1002/cctc.201600075},
year = {2016},
date = {2016-01-01},
journal = {ChemCatChem},
volume = {8},
number = {6},
pages = {1038-1042},
keywords = {},
pubstate = {published},
tppubtype = {article}
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Wells, A S; Wong, J W; Michels, P C; Entwistle, D A; Fandrick, K; Finch, G L; Goswami, A; Lee, H; Mix, S; Moody, T S; Pang, L; Sato, R K; Turner, N J; Watson, T J
@article{Wells2016594,
title = {Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form},
author = {A S Wells and J W Wong and P C Michels and D A Entwistle and K Fandrick and G L Finch and A Goswami and H Lee and S Mix and T S Moody and L Pang and R K Sato and N J Turner and T J Watson},
doi = {10.1021/acs.oprd.5b00369},
year = {2016},
date = {2016-01-01},
journal = {Organic Process Research and Development},
volume = {20},
number = {3},
pages = {594-601},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Eichler2016426,
title = {Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling},
author = {A Eichler and Ł Gricman and S Herter and P P Kelly and N J Turner and J Pleiss and S L Flitsch},
doi = {10.1002/cbic.201500536},
year = {2016},
date = {2016-01-01},
journal = {ChemBioChem},
volume = {17},
number = {5},
pages = {426-432},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Willies2016,
title = {A stereospecific solid-phase screening assay for colonies expressing both (R)-and (S)-selective Ω-Aminotransferases},
author = {S C Willies and J L Galman and I Slabu and N J Turner},
doi = {10.1098/rsta.2015.0084},
year = {2016},
date = {2016-01-01},
journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
volume = {374},
number = {2061},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Grogan20161900,
title = {InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines},
author = {G Grogan and N J Turner},
doi = {10.1002/chem.201503954},
year = {2016},
date = {2016-01-01},
journal = {Chemistry - A European Journal},
volume = {22},
number = {6},
pages = {1900-1907},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Both20161511,
title = {Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions},
author = {P Both and H Busch and P P Kelly and F G Mutti and N J Turner and S L Flitsch},
doi = {10.1002/anie.201510028},
year = {2016},
date = {2016-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {55},
number = {4},
pages = {1511-1513},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Heath2016117,
title = {Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles},
author = {R S Heath and M Pontini and S Hussain and N J Turner},
doi = {10.1002/cctc.201500822},
year = {2016},
date = {2016-01-01},
journal = {ChemCatChem},
volume = {8},
number = {1},
pages = {117-120},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Fisk201659,
title = {Achieving optimal SERS through enhanced experimental design},
author = {H Fisk and C Westley and N J Turner and R Goodacre},
doi = {10.1002/jrs.4855},
year = {2016},
date = {2016-01-01},
journal = {Journal of Raman Spectroscopy},
volume = {47},
number = {1},
pages = {59-66},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Roselló20165172,
title = {Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation},
author = {J M Roselló and S Staniland and N J Turner and J Clayden},
doi = {10.1016/j.tet.2016.01.037},
year = {2016},
date = {2016-01-01},
journal = {Tetrahedron},
volume = {72},
number = {34},
pages = {5172-5177},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20167256,
title = {Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes},
author = {F Parmeggiani and S T Ahmed and N J Weise and N J Turner},
doi = {10.1016/j.tet.2015.12.063},
year = {2016},
date = {2016-01-01},
journal = {Tetrahedron},
volume = {72},
number = {46},
pages = {7256-7262},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hugentobler20168064,
title = {Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor},
author = {K G Hugentobler and H Sharif and M Rasparini and R S Heath and N J Turner},
doi = {10.1039/c6ob01382a},
year = {2016},
date = {2016-01-01},
journal = {Organic and Biomolecular Chemistry},
volume = {14},
number = {34},
pages = {8064-8067},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Rowles20167343,
title = {Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids},
author = {I Rowles and B Groenendaal and B Binay and K J Malone and S C Willies and N J Turner},
doi = {10.1016/j.tet.2016.06.026},
year = {2016},
date = {2016-01-01},
journal = {Tetrahedron},
volume = {72},
number = {46},
pages = {7343-7347},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise20164086,
title = {Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source},
author = {N J Weise and S T Ahmed and F Parmeggiani and E Siirola and A Pushpanath and U Schell and N J Turner},
doi = {10.1039/c6cy00855k},
year = {2016},
date = {2016-01-01},
journal = {Catalysis Science and Technology},
volume = {6},
number = {12},
pages = {4086-4089},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20163298,
title = {Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase},
author = {F Parmeggiani and S T Ahmed and M P Thompson and N J Weise and J L Galman and D Gahloth and M S Dunstan and D Leys and N J Turner},
doi = {10.1002/adsc.201600682},
year = {2016},
date = {2016-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {358},
number = {20},
pages = {3298-3306},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weissenborn20166158,
title = {Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s},
author = {M J Weissenborn and S Notonier and S -L Lang and K B Otte and S Herter and N J Turner and S L Flitsch and B Hauer},
doi = {10.1039/c6cc01749e},
year = {2016},
date = {2016-01-01},
journal = {Chemical Communications},
volume = {52},
number = {36},
pages = {6158-6161},
keywords = {},
pubstate = {published},
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@article{Staniland201610755,
title = {Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts},
author = {S Staniland and R W Adams and J J W McDouall and I Maffucci and A Contini and D M Grainger and N J Turner and J Clayden},
doi = {10.1002/anie.201605486},
year = {2016},
date = {2016-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {55},
number = {36},
pages = {10755-10759},
keywords = {},
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@article{deGraaff20161555,
title = {Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer},
author = {C de Graaff and B Oppelaar and O Péruch and C M L Vande Velde and B Bechi and N J Turner and E Ruijter and R V A Orru},
doi = {10.1002/adsc.201600038},
year = {2016},
date = {2016-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {358},
number = {10},
pages = {1555-1560},
keywords = {},
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@article{Özgün2015212,
title = {Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum},
author = {G Özgün and N G Karagüler and O Turunen and N J Turner and B Binay},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944199017&doi=10.1016%2fj.molcatb.2015.09.014&partnerID=40&md5=21bd4f6a48f0fa3e44e411c155bd0e54},
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year = {2015},
date = {2015-01-01},
journal = {Journal of Molecular Catalysis B: Enzymatic},
volume = {122},
pages = {212-217},
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@article{ToftgaardPedersen20151580,
title = {Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols},
author = {A Toftgaard Pedersen and W R Birmingham and G Rehn and S J Charnock and N J Turner and J M Woodley},
doi = {10.1021/acs.oprd.5b00278},
year = {2015},
date = {2015-01-01},
journal = {Organic Process Research and Development},
volume = {19},
number = {11},
pages = {1580-1589},
keywords = {},
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@article{DeGraaff201514133,
title = {Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction},
author = {C De Graaff and L Bensch and S J Boersma and R C Cioc and M J Van Lint and E Janssen and N J Turner and R V A Orru and E Ruijter},
doi = {10.1002/anie.201507041},
year = {2015},
date = {2015-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {54},
number = {47},
pages = {14133-14136},
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@article{Weise201512977,
title = {The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids},
author = {N J Weise and F Parmeggiani and S T Ahmed and N J Turner},
doi = {10.1021/jacs.5b07326},
year = {2015},
date = {2015-01-01},
journal = {Journal of the American Chemical Society},
volume = {137},
number = {40},
pages = {12977-12983},
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@article{Mutti20151525,
title = {Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades},
author = {F G Mutti and T Knaus and N S Scrutton and M Breuer and N J Turner},
doi = {10.1126/science.aac9283},
year = {2015},
date = {2015-01-01},
journal = {Science},
volume = {349},
number = {6255},
pages = {1525-1529},
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@article{Kelly20151713,
title = {Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions},
author = {P P Kelly and A Eichler and S Herter and D C Kranz and N J Turner and S L Flitsch},
doi = {10.3762/bjoc.11.186},
year = {2015},
date = {2015-01-01},
journal = {Beilstein Journal of Organic Chemistry},
volume = {11},
pages = {1713-1720},
keywords = {},
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@article{Ahmed20155410,
title = {Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation},
author = {S T Ahmed and F Parmeggiani and N J Weise and S L Flitsch and N J Turner},
doi = {10.1021/acscatal.5b01132},
year = {2015},
date = {2015-01-01},
journal = {ACS Catalysis},
volume = {5},
number = {9},
pages = {5410-5413},
keywords = {},
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@article{Herter20152313,
title = {Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis},
author = {S Herter and S M McKenna and A R Frazer and S Leimkühler and A J Carnell and N J Turner},
doi = {10.1002/cctc.201500218},
year = {2015},
date = {2015-01-01},
journal = {ChemCatChem},
volume = {7},
number = {15},
pages = {2313-2317},
keywords = {},
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@article{McKenna20153271,
title = {Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem},
author = {S M McKenna and S Leimkühler and S Herter and N J Turner and A J Carnell},
doi = {10.1039/c5gc00707k},
year = {2015},
date = {2015-01-01},
journal = {Green Chemistry},
volume = {17},
number = {6},
pages = {3271-3275},
keywords = {},
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@article{Man20151052,
title = {Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline},
author = {H Man and E Wells and S Hussain and Dr. Leipold F. and S Hart and Dr. Turkenburg J.P. and Prof. Dr. Turner N.J. and G Grogan},
doi = {10.1002/cbic.201402625},
year = {2015},
date = {2015-01-01},
journal = {ChemBioChem},
volume = {16},
number = {7},
pages = {1052-1059},
keywords = {},
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@article{Faber20151565,
title = {Engineering biocatalysts for synthesis including cascade processes},
author = {K Faber and W -D Fessner and N J Turner},
doi = {10.1002/adsc.201500450},
year = {2015},
date = {2015-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {357},
number = {8},
pages = {1565-1566},
keywords = {},
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@article{Parmeggiani20154608,
title = {Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process},
author = {F Parmeggiani and S L Lovelock and N J Weise and S T Ahmed and N J Turner},
doi = {10.1002/anie.201410670},
year = {2015},
date = {2015-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {54},
number = {15},
pages = {4608-4611},
keywords = {},
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@article{Knaus2015223,
title = {Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes},
author = {T Knaus and F G Mutti and L D Humphreys and N J Turner and N S Scrutton},
doi = {10.1039/c4ob02282c},
year = {2015},
date = {2015-01-01},
journal = {Organic and Biomolecular Chemistry},
volume = {13},
number = {1},
pages = {223-233},
keywords = {},
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@article{Hussain2015579,
title = {An (R)-imine reductase biocatalyst for the asymmetric reduction of cyclic imines},
author = {S Hussain and F Leipold and H Man and E Wells and S P France and K R Mulholland and G Grogan and N J Turner},
doi = {10.1002/cctc.201402797},
year = {2015},
date = {2015-01-01},
journal = {ChemCatChem},
volume = {7},
number = {4},
pages = {579-583},
keywords = {},
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@article{Bechi20144524,
title = {Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis},
author = {B Bechi and S Herter and S McKenna and C Riley and S Leimkühler and N J Turner and A J Carnell},
doi = {10.1039/c4gc01321b},
year = {2014},
date = {2014-01-01},
journal = {Green Chemistry},
volume = {16},
number = {10},
pages = {4524-4529},
keywords = {},
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@article{Staniland201413084,
title = {Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers},
author = {S Staniland and B Yuan and N Giménez-Agullõ and T Marcelli and S C Willies and D M Grainger and N J Turner and J Clayden},
doi = {10.1002/chem.201404509},
year = {2014},
date = {2014-01-01},
journal = {Chemistry - A European Journal},
volume = {20},
number = {41},
pages = {13084-13088},
keywords = {},
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@article{Scheller20142201,
title = {Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases},
author = {P N Scheller and S Fademrecht and S Hofelzer and J Pleiss and F Leipold and N J Turner and B M Nestl and B Hauer},
doi = {10.1002/cbic.201402213},
year = {2014},
date = {2014-01-01},
journal = {ChemBioChem},
volume = {15},
number = {15},
pages = {2201-2204},
keywords = {},
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@article{Schrittwieser20143657,
title = {Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants},
author = {J H Schrittwieser and B Groenendaal and S C Willies and D Ghislieri and I Rowles and V Resch and J H Sattler and E -M Fischereder and B Grischek and W -D Lienhart and N J Turner and W Kroutil},
doi = {10.1039/c4cy00642a},
year = {2014},
date = {2014-01-01},
journal = {Catalysis Science and Technology},
volume = {4},
number = {10},
pages = {3657-3664},
keywords = {},
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@article{Green201410714,
title = {Chiral amine synthesis using ω-transaminases: An amine donor that displaces equilibria and enables high-throughput screening},
author = {A P Green and N J Turner and E O'Reilly},
doi = {10.1002/anie.201406571},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {40},
pages = {10714-10717},
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@book{Humphrey2014123,
title = {Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions},
author = {C E Humphrey and M Ahmed and A Ghanem and N J Turner},
doi = {10.1002/9783527650880.ch4},
year = {2014},
date = {2014-01-01},
journal = {Separation of Enantiomers: Synthetic Methods},
volume = {9783527330454},
pages = {123-160},
keywords = {},
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@article{Lovelock20144652,
title = {Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway},
author = {S L Lovelock and R C Lloyd and N J Turner},
doi = {10.1002/anie.201311061},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {18},
pages = {4652-4656},
keywords = {},
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@article{Schrittwieser20143731,
title = {Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion},
author = {J H Schrittwieser and B Groenendaal and V Resch and D Ghislieri and S Wallner and E -M Fischereder and E Fuchs and B Grischek and J H Sattler and P MacHeroux and N J Turner and W Kroutil},
doi = {10.1002/anie.201400027},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {14},
pages = {3731-3734},
keywords = {},
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@article{Ghislieri2014284,
title = {Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines},
author = {D Ghislieri and N J Turner},
doi = {10.1007/s11244-013-0184-1},
year = {2014},
date = {2014-01-01},
journal = {Topics in Catalysis},
volume = {57},
number = {5},
pages = {284-300},
keywords = {},
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@article{Turner2014283,
title = {Foreword},
author = {N J Turner and J Whittall and T R Ward},
doi = {10.1007/s11244-013-0186-z},
year = {2014},
date = {2014-01-01},
journal = {Topics in Catalysis},
volume = {57},
number = {5},
pages = {283},
keywords = {},
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@article{O'Reilly20142447,
title = {A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines},
author = {E O'Reilly and C Iglesias and D Ghislieri and J Hopwood and J L Galman and R C Lloyd and N J Turner},
doi = {10.1002/anie.201309208},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {9},
pages = {2447-2450},
keywords = {},
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@book{Turner2014328,
title = {A Reduction of C N to CH-NH Using Enzymes and Microorganisms},
author = {N J Turner},
doi = {10.1016/B978-0-08-097742-3.00810-7},
year = {2014},
date = {2014-01-01},
journal = {Comprehensive Organic Synthesis: Second Edition},
volume = {8},
pages = {328-338},
keywords = {},
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@article{Heath2014996,
title = {Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity},
author = {R S Heath and M Pontini and B Bechi and N J Turner},
doi = {10.1002/cctc.201301008},
year = {2014},
date = {2014-01-01},
journal = {ChemCatChem},
volume = {6},
number = {4},
pages = {996-1002},
keywords = {},
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@article{O'Reilly2014992,
title = {Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines},
author = {E O'Reilly and C Iglesias and N J Turner},
doi = {10.1002/cctc.201300990},
year = {2014},
date = {2014-01-01},
journal = {ChemCatChem},
volume = {6},
number = {4},
pages = {992-995},
keywords = {},
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@article{Heap20142251,
title = {Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification},
author = {L Heap and A Green and D Brown and B Van Dongen and N Turner},
doi = {10.1039/c4cy00046c},
year = {2014},
date = {2014-01-01},
journal = {Catalysis Science and Technology},
volume = {4},
number = {8},
pages = {2251-2259},
keywords = {},
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@article{Zajkoska20141229,
title = {Immobilised whole-cell recombinant monoamine oxidase biocatalysis},
author = {P Zajkoska and M Rosenberg and R Heath and K J Malone and R Stloukal and N J Turner and M Rebroš},
doi = {10.1007/s00253-014-5983-1},
year = {2014},
date = {2014-01-01},
journal = {Applied Microbiology and Biotechnology},
volume = {99},
number = {3},
pages = {1229-1236},
keywords = {},
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@article{Ghislieri20132869,
title = {Monoamine oxidase (MAO-N) catalyzed deracemization of tetrahydro-β- carbolines: Substrate dependent switch in enantioselectivity},
author = {D Ghislieri and D Houghton and A P Green and S C Willies and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890423869&doi=10.1021%2fcs400724g&partnerID=40&md5=fec581eb3481e9ab3ccfcd940675e141},
doi = {10.1021/cs400724g},
year = {2013},
date = {2013-01-01},
journal = {ACS Catalysis},
volume = {3},
number = {12},
pages = {2869-2872},
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@article{Leipold20133505,
title = {Asymmetric reduction of cyclic imines catalyzed by a whole-cell biocatalyst containing an (S)-imine reductase},
author = {F Leipold and S Hussain and D Ghislieri and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84889865225&doi=10.1002%2fcctc.201300539&partnerID=40&md5=8bda0de5ee4f52aab4822da05ba47ed4},
doi = {10.1002/cctc.201300539},
year = {2013},
date = {2013-01-01},
journal = {ChemCatChem},
volume = {5},
number = {12},
pages = {3505-3508},
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@article{Ghislieri201310863,
title = {Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products},
author = {D Ghislieri and A P Green and M Pontini and S C Willies and I Rowles and A Frank and G Grogan and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880831531&doi=10.1021%2fja4051235&partnerID=40&md5=53f9d546f34e0de1e810e2e6f010fd39},
doi = {10.1021/ja4051235},
year = {2013},
date = {2013-01-01},
journal = {Journal of the American Chemical Society},
volume = {135},
number = {29},
pages = {10863-10869},
keywords = {},
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@article{Rodríguez-Mata20131372,
title = {Structure and activity of NADPH-dependent reductase Q1EQE0 from streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate},
author = {M Rodríguez-Mata and A Frank and E Wells and F Leipold and N J Turner and S Hart and J P Turkenburg and G Grogan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880588738&doi=10.1002%2fcbic.201300321&partnerID=40&md5=683e2e30fa394afb63a0eba8a79d52b7},
doi = {10.1002/cbic.201300321},
year = {2013},
date = {2013-01-01},
journal = {ChemBioChem},
volume = {14},
number = {11},
pages = {1372-1379},
keywords = {},
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@article{O'Reilly20131490,
title = {Substrate promiscuity of cytochrome P450 RhF},
author = {E O'Reilly and M Corbett and S Hussain and P P Kelly and D Richardson and S L Flitsch and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878090066&doi=10.1039%2fc3cy00091e&partnerID=40&md5=37cd1c9cd2421ad176860bf04452d348},
doi = {10.1039/c3cy00091e},
year = {2013},
date = {2013-01-01},
journal = {Catalysis Science and Technology},
volume = {3},
number = {6},
pages = {1490-1492},
keywords = {},
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@book{Turner201363,
title = {Synthesis of Chiral Amines Using Transaminases},
author = {N J Turner and M D Truppo},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886158528&doi=10.1002%2f9781118354520.ch03&partnerID=40&md5=6e21cd20df73f287d7260b85ae8289ec},
doi = {10.1002/9781118354520.ch03},
year = {2013},
date = {2013-01-01},
journal = {Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries},
pages = {63-74},
keywords = {},
pubstate = {published},
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@article{Turner2013212,
title = {Biocatalysis enters a new era},
author = {N J Turner and M D Truppo},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876720316&doi=10.1016%2fj.cbpa.2013.02.026&partnerID=40&md5=d10caaf8dc15b753211bf4156fdedd3a},
doi = {10.1016/j.cbpa.2013.02.026},
year = {2013},
date = {2013-01-01},
journal = {Current Opinion in Chemical Biology},
volume = {17},
number = {2},
pages = {212-214},
keywords = {},
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@article{Köhler201393,
title = {Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes},
author = {V Köhler and Y M Wilson and M Dürrenberger and D Ghislieri and E Churakova and T Quinto and L Knörr and D Häussinger and F Hollmann and N J Turner and T R Ward},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873872136&doi=10.1038%2fnchem.1498&partnerID=40&md5=97106701f55923bd64548e94d89141d2},
doi = {10.1038/nchem.1498},
year = {2013},
date = {2013-01-01},
journal = {Nature Chemistry},
volume = {5},
number = {2},
pages = {93-99},
keywords = {},
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@article{KalimAkhtara201387,
title = {Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities},
author = {M Kalim Akhtara and N J Turner and P R Jones},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871952399&doi=10.1073%2fpnas.1216516110&partnerID=40&md5=a1cb6a1e13e8d2dd739903d9712912a3},
doi = {10.1073/pnas.1216516110},
year = {2013},
date = {2013-01-01},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
volume = {110},
number = {1},
pages = {87-92},
keywords = {},
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@article{Willies20127564,
title = {Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine},
author = {S C Willies and J L White and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864420613&doi=10.1016%2fj.tet.2012.06.062&partnerID=40&md5=c15ee495f78f1f45d115c6b175146eb0},
doi = {10.1016/j.tet.2012.06.062},
year = {2012},
date = {2012-01-01},
journal = {Tetrahedron},
volume = {68},
number = {37},
pages = {7564-7567},
keywords = {},
pubstate = {published},
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@article{Rowles20121259,
title = {Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea},
author = {I Rowles and K J Malone and L L Etchells and S C Willies and N J Turner},
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title = {A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A},
author = {K R Bailey and A J Ellis and R Reiss and T J Snape and N J Turner},
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title = {Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst},
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title = {Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp.},
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title = {A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines},
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@article{Çelik20052930,
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@article{Çelik20052688,
title = {Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium},
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@article{Çelik20053652,
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title = {Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines},
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title = {Efficient palladium-catalyzed cross-coupling of β-chloroalkylidene/ arylidene malonates using microwave chemistry},
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title = {Rapid identification of cytochrome P450 cam variants by in vivo screening of active site libraries},
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@article{Moore20041133,
title = {Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering},
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@article{Humphrey20041144,
title = {Dimedone esters as novel hydrolase substrates and their application in the colorimetric detection of lipase and esterase activity},
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@article{Roff20044098,
title = {A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids},
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@article{Roberts200496,
title = {Nucleotide sequence of a portion of the camphor-degrading gene cluster from Rhodococcus sp. NCIMB 9784},
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@article{Lins2004771,
title = {Generation of a dynamic combinatorial library using sialic acid aldolase and in situ screening against wheat germ agglutinin},
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title = {Directed evolution of enzymes: New biocatalysts for asymmetric synthesis},
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@article{Humphrey200313952,
title = {Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy},
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title = {Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity},
author = {R Carr and M Alexeeva and A Enright and T S C Eve and M J Dawson and N J Turner},
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title = {Solid-supported cyclohexane-1,3-dione (CHD): A "capture and release" reagent for the synthesis of amides and novel scavenger resin},
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title = {Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations},
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title = {Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation-reduction procedure},
author = {A Enright and F R Alexandre and G Roff and I G Fotheringham and M J Dawson and N J Turner},
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title = {A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center.},
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journal = {The Journal of biological chemistry},
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title = {P450camr, a cytochrome P450 catalysing the stereospecific 6-endo-hydroxylation of (1R)-(+)-camphor},
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title = {Enzymatic generation and in situ screening of a dynamic combinatorial library of sialic acid analogues},
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title = {Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution},
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