@article{Thompson2019327,
title = {A generic platform for the immobilisation of engineered biocatalysts},
author = {M P Thompson and S R Derrington and R S Heath and J L Porter and J Mangas-Sanchez and P N Devine and M D Truppo and N J Turner},
doi = {10.1016/j.tet.2018.12.004},
year = {2019},
date = {2019-01-01},
journal = {Tetrahedron},
volume = {75},
number = {3},
pages = {327-334},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Heath2019276,
title = {An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols},
author = {R S Heath and W R Birmingham and M P Thompson and A Taglieber and L Daviet and N J Turner},
doi = {10.1002/cbic.201800556},
year = {2019},
date = {2019-01-01},
journal = {ChemBioChem},
volume = {20},
number = {2},
pages = {276-281},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Thompson20199,
title = {Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals},
author = {M P Thompson and I Peñafiel and S C Cosgrove and N J Turner},
doi = {10.1021/acs.oprd.8b00305},
year = {2019},
date = {2019-01-01},
journal = {Organic Process Research and Development},
volume = {23},
number = {1},
pages = {9-18},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ramsden20191201,
title = {Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades},
author = {J I Ramsden and R S Heath and S R Derrington and S L Montgomery and J Mangas-Sanchez and K R Mulholland and N J Turner},
doi = {10.1021/jacs.8b11561},
year = {2019},
date = {2019-01-01},
journal = {Journal of the American Chemical Society},
volume = {141},
number = {3},
pages = {1201-1206},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Megarity, C F; Siritanaratkul, B; Heath, R S; Wan, L; Morello, G; FitzPatrick, S R; Booth, R L; Sills, A J; Robertson, A W; Warner, J H; Turner, N J; Armstrong, F A
@article{Megarity20194948,
title = {Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores},
author = {C F Megarity and B Siritanaratkul and R S Heath and L Wan and G Morello and S R FitzPatrick and R L Booth and A J Sills and A W Robertson and J H Warner and N J Turner and F A Armstrong},
doi = {10.1002/anie.201814370},
year = {2019},
date = {2019-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {58},
number = {15},
pages = {4948-4952},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Manning20195668,
title = {Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S)-δ-Decalactone},
author = {J Manning and M Tavanti and J L Porter and N Kress and S P De Visser and N J Turner and S L Flitsch},
doi = {10.1002/anie.201901242},
year = {2019},
date = {2019-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {58},
number = {17},
pages = {5668-5671},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20193482,
title = {One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase},
author = {F Parmeggiani and A Rué Casamajo and C J W Walton and J L Galman and N J Turner and R A Chica},
doi = {10.1021/acscatal.9b00739},
year = {2019},
date = {2019-01-01},
journal = {ACS Catalysis},
volume = {9},
number = {4},
pages = {3482-3486},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Bornadel20191262,
title = {Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study},
author = {A Bornadel and S Bisagni and A Pushpanath and S L Montgomery and N J Turner and B Dominguez},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067690635&doi=10.1021%2facs.oprd.9b00123&partnerID=40&md5=5f146067233716ead0a37d8e75ca2406},
doi = {10.1021/acs.oprd.9b00123},
year = {2019},
date = {2019-01-01},
journal = {Organic Process Research and Development},
volume = {23},
number = {6},
pages = {1262-1268},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Currin20191371,
title = {GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries},
author = {A Currin and J Kwok and J C Sadler and E L Bell and N Swainston and M Ababi and P Day and N J Turner and D B Kell},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067556821&doi=10.1021%2facssynbio.9b00063&partnerID=40&md5=231ddfa9749bcdc560c28ee714e096a2},
doi = {10.1021/acssynbio.9b00063},
year = {2019},
date = {2019-01-01},
journal = {ACS Synthetic Biology},
volume = {8},
number = {6},
pages = {1371-1378},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{C9GC00270Gb,
title = {Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles},
author = {Richard L Kimber and Fabio Parmeggiani and Nimisha Joshi and Alexander M Rakowski and Sarah J Haigh and Nicholas J Turner and Jonathan R Lloyd},
url = {http://dx.doi.org/10.1039/C9GC00270G},
doi = {10.1039/C9GC00270G},
year = {2019},
date = {2019-01-01},
journal = {Green Chem.},
pages = {-},
publisher = {The Royal Society of Chemistry},
abstract = {Copper recovered from a whisky distillery waste stream is shown to be an effective catalyst for a range of azide–alkyne “click” reactions. Biogenic nanomagnetite (BNM), produced under mild conditions, was used to rapidly recover and subsequently support the Cu catalyst which could be separated and recycled easily.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Copper recovered from a whisky distillery waste stream is shown to be an effective catalyst for a range of azide–alkyne “click” reactions. Biogenic nanomagnetite (BNM), produced under mild conditions, was used to rapidly recover and subsequently support the Cu catalyst which could be separated and recycled easily.
@article{C9GC01902B,
title = {Biocatalytic retrosynthesis approaches to D-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin},
author = {Fabio Parmeggiani and Arnau Rué Casamajo and Danilo Colombo and Maria Chiara Ghezzi and James Louis Galman and Roberto A Chica and Elisabetta Brenna and Nicholas J Turner},
url = {http://dx.doi.org/10.1039/C9GC01902B},
doi = {10.1039/C9GC01902B},
year = {2019},
date = {2019-01-01},
journal = {Green Chem.},
pages = {-},
publisher = {The Royal Society of Chemistry},
abstract = {The integration of biocatalytic steps in retrosynthetic analysis of a target molecule offers multiple advantages, such as reduction of the environmental footprint of the process, viability of milder and safer reaction conditions, and accessibility of transformations that are challenging with traditional chemical synthesis. Herein, six chemo-enzymatic routes are described for the synthesis of a fluorinated D-phenylalanine derivative, precursor of the blockbuster antidiabetic drug sitagliptin. All routes start from the same aldehyde precursor and involve at least one biocatalytic step, including reductive amination, transamination, deracemisation, hydroamination, and alkene reduction. The target molecule was obtained in 2-5 steps from the aldehyde, with ee up to >99% and in 36-62% isolated yield. Furthermore, as part of one of the routes, the first example of a fully biocatalytic conversion of a cinnamic acid derivative to the corresponding D-phenylalanine (formal D-selective hydroamination) is reported.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The integration of biocatalytic steps in retrosynthetic analysis of a target molecule offers multiple advantages, such as reduction of the environmental footprint of the process, viability of milder and safer reaction conditions, and accessibility of transformations that are challenging with traditional chemical synthesis. Herein, six chemo-enzymatic routes are described for the synthesis of a fluorinated D-phenylalanine derivative, precursor of the blockbuster antidiabetic drug sitagliptin. All routes start from the same aldehyde precursor and involve at least one biocatalytic step, including reductive amination, transamination, deracemisation, hydroamination, and alkene reduction. The target molecule was obtained in 2-5 steps from the aldehyde, with ee up to >99% and in 36-62% isolated yield. Furthermore, as part of one of the routes, the first example of a fully biocatalytic conversion of a cinnamic acid derivative to the corresponding D-phenylalanine (formal D-selective hydroamination) is reported.
@article{Odachowski201810032,
title = {Concurrent Biocatalytic Oxidation and C-C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines},
author = {M Odachowski and M F Greaney and N J Turner},
doi = {10.1021/acscatal.8b03169},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {11},
pages = {10032-10035},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Costa20184733,
title = {Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts},
author = {B Z Costa and J L Galman and I Slabu and S P France and A J Marsaioli and N J Turner},
doi = {10.1002/cctc.201801166},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {20},
pages = {4733-4738},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Toscani20188781,
title = {Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines},
author = {A Toscani and C Risi and G W Black and N L Brown and A Shaaban and N J Turner and D Castagnolo},
doi = {10.1021/acscatal.8b02386},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {9},
pages = {8781-8787},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Chapman201810535,
title = {Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen},
author = {M R Chapman and S C Cosgrove and N J Turner and N Kapur and A J Blacker},
doi = {10.1002/anie.201803675},
year = {2018},
date = {2018-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {57},
number = {33},
pages = {10535-10539},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Tavanti2018846,
title = {The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s},
author = {M Tavanti and J L Porter and C W Levy and J R Gómez Castellanos and S L Flitsch and N J Turner},
doi = {10.1016/j.bbrc.2018.05.014},
year = {2018},
date = {2018-01-01},
journal = {Biochemical and Biophysical Research Communications},
volume = {501},
number = {4},
pages = {846-850},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Carbonell20182153,
title = {Selenzyme: Enzyme selection tool for pathway design},
author = {P Carbonell and J Wong and N Swainston and E Takano and N J Turner and N S Scrutton and D B Kell and R Breitling and J -L Faulon},
doi = {10.1093/bioinformatics/bty065},
year = {2018},
date = {2018-01-01},
journal = {Bioinformatics},
volume = {34},
number = {12},
pages = {2153-2154},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Cosgrove20185570,
title = {Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines},
author = {S C Cosgrove and S Hussain and N J Turner and S P Marsden},
doi = {10.1021/acscatal.8b01220},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {6},
pages = {5570-5573},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Porter20181,
title = {Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope},
author = {J L Porter and S Sabatini and J Manning and M Tavanti and J L Galman and N J Turner and S L Flitsch},
doi = {10.1016/j.enzmictec.2018.02.005},
year = {2018},
date = {2018-01-01},
journal = {Enzyme and Microbial Technology},
volume = {113},
pages = {1-8},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Slabu201896,
title = {n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones},
author = {I Slabu and J L Galman and C Iglesias and N J Weise and R C Lloyd and N J Turner},
doi = {10.1016/j.cattod.2017.01.025},
year = {2018},
date = {2018-01-01},
journal = {Catalysis Today},
volume = {306},
pages = {96-101},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Birmingham20184025,
title = {A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase},
author = {W R Birmingham and N J Turner},
doi = {10.1021/acscatal.8b00043},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {5},
pages = {4025-4032},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Çakar2018327,
title = {Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii},
author = {M M Çakar and J Mangas-Sanchez and W R Birmingham and N J Turner and B Binay},
doi = {10.1080/10826068.2018.1446150},
year = {2018},
date = {2018-01-01},
journal = {Preparative Biochemistry and Biotechnology},
volume = {48},
number = {4},
pages = {327-334},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ahmed20183129,
title = {Engineered ammonia lyases for the production of challenging electron-rich l -phenylalanines},
author = {S T Ahmed and F Parmeggiani and N J Weise and S L Flitsch and N J Turner},
doi = {10.1021/acscatal.8b00496},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {4},
pages = {3129-3132},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Turner2018A1,
title = {Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis},
author = {N J Turner and R Kumar},
doi = {10.1016/j.cbpa.2018.02.012},
year = {2018},
date = {2018-01-01},
journal = {Current Opinion in Chemical Biology},
volume = {43},
pages = {A1-A3},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise2018288,
title = {Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis},
author = {N J Weise and F Parmeggiani and S T Ahmed and N J Turner},
doi = {10.1007/s11244-018-0898-1},
year = {2018},
date = {2018-01-01},
journal = {Topics in Catalysis},
volume = {61},
number = {3-4},
pages = {288-295},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Herter20181338,
title = {Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines},
author = {S Herter and F Medina and S Wagschal and C Benhaïm and F Leipold and N J Turner},
doi = {10.1016/j.bmc.2017.07.023},
year = {2018},
date = {2018-01-01},
journal = {Bioorganic and Medicinal Chemistry},
volume = {26},
number = {7},
pages = {1338-1346},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Morrill20183692,
title = {Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles},
author = {C Morrill and C Jensen and X Just-Baringo and G Grogan and N J Turner and D J Procter},
doi = {10.1002/anie.201800121},
year = {2018},
date = {2018-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {57},
number = {14},
pages = {3692-3696},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Kimber, R L; Lewis, E A; Parmeggiani, F; Smith, K; Bagshaw, H; Starborg, T; Joshi, N; Figueroa, A I; van der Laan, G; Cibin, G; Gianolio, D; Haigh, S J; Pattrick, R A D; Turner, N J; Lloyd, J R
@article{Kimber2018,
title = {Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry},
author = {R L Kimber and E A Lewis and F Parmeggiani and K Smith and H Bagshaw and T Starborg and N Joshi and A I Figueroa and G van der Laan and G Cibin and D Gianolio and S J Haigh and R A D Pattrick and N J Turner and J R Lloyd},
doi = {10.1002/smll.201703145},
year = {2018},
date = {2018-01-01},
journal = {Small},
volume = {14},
number = {10},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Tavanti20181042,
title = {Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope},
author = {M Tavanti and J L Porter and S Sabatini and N J Turner and S L Flitsch},
doi = {10.1002/cctc.201701510},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {5},
pages = {1042-1051},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Porter2018513,
title = {Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids},
author = {J L Porter and J Manning and S Sabatini and M Tavanti and N J Turner and S L Flitsch},
doi = {10.1002/cbic.201700598},
year = {2018},
date = {2018-01-01},
journal = {ChemBioChem},
volume = {19},
number = {5},
pages = {513-520},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Barley2018234,
title = {Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins},
author = {M H Barley and N J Turner and R Goodacre},
doi = {10.1021/acs.jcim.7b00488},
year = {2018},
date = {2018-01-01},
journal = {Journal of Chemical Information and Modeling},
volume = {58},
number = {2},
pages = {234-243},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{France2018510,
title = {Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination},
author = {S P France and R M Howard and J Steflik and N J Weise and J Mangas-Sanchez and S L Montgomery and R Crook and R Kumar and N J Turner},
doi = {10.1002/cctc.201701408},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {3},
pages = {510-514},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aleku2018515,
title = {Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase},
author = {G A Aleku and J Mangas-Sanchez and J Citoler and S P France and S L Montgomery and R S Heath and M P Thompson and N J Turner},
doi = {10.1002/cctc.201701484},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {3},
pages = {515-519},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Walton2018470,
title = {Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades},
author = {C J W Walton and F Parmeggiani and J E B Barber and J L McCann and N J Turner and R A Chica},
doi = {10.1002/cctc.201701068},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {2},
pages = {470-474},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hutchings2018,
title = {Providing sustainable catalytic solutions for a rapidly changing world},
author = {G J Hutchings and C R Catlow and N J Turner},
doi = {10.1098/rsta.2017.0309},
year = {2018},
date = {2018-01-01},
journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
volume = {376},
number = {2110},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aleku2018124,
title = {Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones},
author = {G A Aleku and B Nowicka and N J Turner},
doi = {10.1002/cctc.201700685},
year = {2018},
date = {2018-01-01},
journal = {ChemCatChem},
volume = {10},
number = {1},
pages = {124-135},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Galman201811316,
title = {Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction},
author = {J L Galman and I Slabu and F Parmeggiani and N J Turner},
doi = {10.1039/C8CC06759G},
year = {2018},
date = {2018-01-01},
journal = {Chemical Communications},
volume = {54},
number = {80},
pages = {11316-11319},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani201873,
title = {Synthetic and therapeutic applications of ammonia-lyases and aminomutases},
author = {F Parmeggiani and N J Weise and S T Ahmed and N J Turner},
doi = {10.1021/acs.chemrev.6b00824},
year = {2018},
date = {2018-01-01},
journal = {Chemical Reviews},
volume = {118},
number = {1},
pages = {73-118},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Klumbys2018658,
title = {Bio-derived production of cinnamyl alcohol: Via a three step biocatalytic cascade and metabolic engineering},
author = {E Klumbys and Z Zebec and N J Weise and N J Turner and N S Scrutton},
doi = {10.1039/c7gc03325g},
year = {2018},
date = {2018-01-01},
journal = {Green Chemistry},
volume = {20},
number = {3},
pages = {658-663},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Markošová2018127,
title = {Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris},
author = {K Markošová and A Camattari and M Rosenberg and A Glieder and N J Turner and M Rebroš},
doi = {10.1007/s10529-017-2450-y},
year = {2018},
date = {2018-01-01},
journal = {Biotechnology Letters},
volume = {40},
number = {1},
pages = {127-133},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Sharma201811534,
title = {A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases},
author = {M Sharma and J Mangas-Sanchez and S P France and G A Aleku and S L Montgomery and J I Ramsden and N J Turner and G Grogan},
doi = {10.1021/acscatal.8b03491},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
pages = {11534-11541},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Cosgrove2018131,
title = {Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications},
author = {S C Cosgrove and A Brzezniak and S P France and J I Ramsden and J Mangas-Sanchez and S L Montgomery and R S Heath and N J Turner},
doi = {10.1016/bs.mie.2018.04.022},
year = {2018},
date = {2018-01-01},
journal = {Methods in Enzymology},
volume = {608},
pages = {131-149},
keywords = {},
pubstate = {published},
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@article{Batista201811889,
title = {Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization},
author = {V F Batista and J L Galman and D C Pinto and A M S Silva and N J Turner},
doi = {10.1021/acscatal.8b03525},
year = {2018},
date = {2018-01-01},
journal = {ACS Catalysis},
volume = {8},
number = {12},
pages = {11889-11907},
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@article{Xu201816760,
title = {Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles},
author = {J Xu and A P Green and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057010763&doi=10.1002%2fanie.201810555&partnerID=40&md5=a3353cb0471575cf34876f6915950255},
doi = {10.1002/anie.201810555},
year = {2018},
date = {2018-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {57},
number = {51},
pages = {16760-16763},
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@article{Devine2018409,
title = {Extending the application of biocatalysis to meet the challenges of drug development},
author = {P N Devine and R M Howard and R Kumar and M P Thompson and M D Truppo and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060102129&doi=10.1038%2fs41570-018-0055-1&partnerID=40&md5=66093a04b19e180f6ca493bbc85c9d76},
doi = {10.1038/s41570-018-0055-1},
year = {2018},
date = {2018-01-01},
journal = {Nature Reviews Chemistry},
volume = {2},
number = {12},
pages = {409-421},
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@book{Burke20181,
title = {Active pharmaceutical ingredients in synthesis: Catalytic processes in research and development},
author = {A J Burke and C S Marques and N J Turner and G J Hermann},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060529666&doi=10.1002%2f9783527807253&partnerID=40&md5=885f37990332e0db06c2dc8b78854f82},
doi = {10.1002/9783527807253},
year = {2018},
date = {2018-01-01},
journal = {Active Pharmaceutical Ingredients in Synthesis: Catalytic Processes in Research and Development},
pages = {1-426},
keywords = {},
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@article{Zawodny201817872,
title = {Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement},
author = {W Zawodny and S L Montgomery and J R Marshall and J D Finnigan and N J Turner and J Clayden},
doi = {10.1021/jacs.8b11891},
year = {2018},
date = {2018-01-01},
journal = {Journal of the American Chemical Society},
volume = {140},
number = {51},
pages = {17872-17877},
note = {cited By 0},
keywords = {},
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France, S P; Aleku, G A; Sharma, M; Mangas-Sanchez, J; Howard, R M; Steflik, J; Kumar, R; Adams, R W; Slabu, I; Crook, R; Grogan, G; Wallace, T W; Turner, N J
@article{France201715589,
title = {Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines},
author = {S P France and G A Aleku and M Sharma and J Mangas-Sanchez and R M Howard and J Steflik and R Kumar and R W Adams and I Slabu and R Crook and G Grogan and T W Wallace and N J Turner},
doi = {10.1002/anie.201708453},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {49},
pages = {15589-15593},
keywords = {},
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@article{Slabu20178263,
title = {Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts},
author = {I Slabu and J L Galman and R C Lloyd and N J Turner},
doi = {10.1021/acscatal.7b02686},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {12},
pages = {8263-8284},
keywords = {},
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tppubtype = {article}
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@article{Weise2017,
title = {Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes},
author = {N J Weise and S T Ahmed and F Parmeggiani and J L Galman and M S Dunstan and S J Charnock and D Leys and N J Turner},
doi = {10.1038/s41598-017-13990-0},
year = {2017},
date = {2017-01-01},
journal = {Scientific Reports},
volume = {7},
number = {1},
keywords = {},
pubstate = {published},
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@article{Fisk201712527,
title = {From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy},
author = {H Fisk and Y Xu and C Westley and N J Turner and J Micklefield and R Goodacre},
doi = {10.1021/acs.analchem.7b03742},
year = {2017},
date = {2017-01-01},
journal = {Analytical Chemistry},
volume = {89},
number = {22},
pages = {12527-12532},
keywords = {},
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Wood, A J L; Weise, N J; Frampton, J D; Dunstan, M S; Hollas, M A; Derrington, S R; Lloyd, R C; Quaglia, D; Parmeggiani, F; Leys, D; Turner, N J; Flitsch, S L
@article{Wood201714498,
title = {Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides},
author = {A J L Wood and N J Weise and J D Frampton and M S Dunstan and M A Hollas and S R Derrington and R C Lloyd and D Quaglia and F Parmeggiani and D Leys and N J Turner and S L Flitsch},
doi = {10.1002/anie.201707918},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {46},
pages = {14498-14501},
keywords = {},
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@article{Hartley2017,
title = {Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis},
author = {C J Hartley and N G French and J A Scoble and C C Williams and Q I Churches and A R Frazer and M C Taylor and G Coia and G Simpson and N J Turner and C Scott},
doi = {10.1371/journal.pone.0184183},
year = {2017},
date = {2017-01-01},
journal = {PLoS ONE},
volume = {12},
number = {11},
keywords = {},
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@article{Thompson20173833,
title = {Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase},
author = {M P Thompson and N J Turner},
doi = {10.1002/cctc.201701092},
year = {2017},
date = {2017-01-01},
journal = {ChemCatChem},
volume = {9},
number = {20},
pages = {3833-3836},
keywords = {},
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@article{Aleku2017961,
title = {A reductive aminase from Aspergillus oryzae},
author = {G A Aleku and S P France and H Man and J Mangas-Sanchez and S L Montgomery and M Sharma and F Leipold and S Hussain and G Grogan and N J Turner},
doi = {10.1038/nchem.2782},
year = {2017},
date = {2017-01-01},
journal = {Nature Chemistry},
volume = {9},
number = {10},
pages = {961-969},
keywords = {},
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Chapman, M R; Kwan, M H T; King, G; Jolley, K E; Hussain, M; Hussain, S; Salama, I E; Nino, González C; Thompson, L A; Bayana, M E; Clayton, A D; Nguyen, B N; Turner, N J; Kapur, N; Blacker, A J
@article{Chapman20171294,
title = {Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times},
author = {M R Chapman and M H T Kwan and G King and K E Jolley and M Hussain and S Hussain and I E Salama and C González Nino and L A Thompson and M E Bayana and A D Clayton and B N Nguyen and N J Turner and N Kapur and A J Blacker},
doi = {10.1021/acs.oprd.7b00173},
year = {2017},
date = {2017-01-01},
journal = {Organic Process Research and Development},
volume = {21},
number = {9},
pages = {1294-1301},
keywords = {},
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@article{Tavanti20173338,
title = {One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone},
author = {M Tavanti and F Parmeggiani and J R G Castellanos and A Mattevi and N J Turner},
doi = {10.1002/cctc.201700620},
year = {2017},
date = {2017-01-01},
journal = {ChemCatChem},
volume = {9},
number = {17},
pages = {3338-3348},
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@article{Ahmed201730,
title = {Applications of phenylalanine ammonia lyases in synthesis: Access to enantiopure arylalanines from laboratory scale to industrial production},
author = {S T Ahmed and N J Weise and F Parmeggiani and N J Turner},
url = {https://www.teknoscienze.com/tks_article/applications-of-phenylalanine-ammonia-lyases-in-synthesis/},
year = {2017},
date = {2017-01-01},
journal = {Chimica Oggi/Chemistry Today},
volume = {35},
number = {5},
pages = {30-33},
keywords = {},
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@article{Gahloth2017975,
title = {Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis},
author = {D Gahloth and M S Dunstan and D Quaglia and E Klumbys and M P Lockhart-Cairns and A M Hill and S R Derrington and N S Scrutton and N J Turner and D Leys},
doi = {10.1038/nchembio.2434},
year = {2017},
date = {2017-01-01},
journal = {Nature Chemical Biology},
volume = {13},
number = {9},
pages = {975-981},
keywords = {},
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@article{Zajkoska20171558,
title = {Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase},
author = {P Zajkoska and M Cárdenas-Fernández and G J Lye and M Rosenberg and N J Turner and M Rebroš},
doi = {10.1002/jctb.5146},
year = {2017},
date = {2017-01-01},
journal = {Journal of Chemical Technology and Biotechnology},
volume = {92},
number = {7},
pages = {1558-1565},
keywords = {},
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@article{Barley20171087,
title = {Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes},
author = {M H Barley and N J Turner and R Goodacre},
doi = {10.1002/cbic.201700013},
year = {2017},
date = {2017-01-01},
journal = {ChemBioChem},
volume = {18},
number = {12},
pages = {1087-1097},
keywords = {},
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@article{Sharma20172011,
title = {NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application},
author = {M Sharma and J Mangas-Sanchez and N J Turner and G Grogan},
doi = {10.1002/adsc.201700356},
year = {2017},
date = {2017-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {359},
number = {12},
pages = {2011-2025},
keywords = {},
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@article{Weise20171570,
title = {Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts},
author = {N J Weise and S T Ahmed and F Parmeggiani and N J Turner},
doi = {10.1002/adsc.201600894},
year = {2017},
date = {2017-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {359},
number = {9},
pages = {1570-1576},
keywords = {},
pubstate = {published},
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@article{Hepworth20172920,
title = {Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines},
author = {L J Hepworth and S P France and S Hussain and P Both and N J Turner and S L Flitsch},
doi = {10.1021/acscatal.7b00513},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {4},
pages = {2920-2925},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Mangas-Sanchez201719,
title = {Imine reductases (IREDs)},
author = {J Mangas-Sanchez and S P France and S L Montgomery and G A Aleku and H Man and M Sharma and J I Ramsden and G Grogan and N J Turner},
doi = {10.1016/j.cbpa.2016.11.022},
year = {2017},
date = {2017-01-01},
journal = {Current Opinion in Chemical Biology},
volume = {37},
pages = {19-25},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Klenk2017,
title = {The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac},
author = {J M Klenk and B A Nebel and J L Porter and J K Kulig and S A Hussain and S M Richter and M Tavanti and N J Turner and M A Hayes and B Hauer and S L Flitsch},
doi = {10.1002/biot.201600520},
year = {2017},
date = {2017-01-01},
journal = {Biotechnology Journal},
volume = {12},
number = {3},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Westley20172472,
title = {Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method},
author = {C Westley and Y Xu and B Thilaganathan and A J Carnell and N J Turner and R Goodacre},
doi = {10.1021/acs.analchem.6b04588},
year = {2017},
date = {2017-01-01},
journal = {Analytical Chemistry},
volume = {89},
number = {4},
pages = {2472-2477},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Hugentobler2017195,
title = {Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor},
author = {K G Hugentobler and M Rasparini and L A Thompson and K E Jolley and A J Blacker and N J Turner},
doi = {10.1021/acs.oprd.6b00346},
year = {2017},
date = {2017-01-01},
journal = {Organic Process Research and Development},
volume = {21},
number = {2},
pages = {195-199},
keywords = {},
pubstate = {published},
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@article{Scalacci20171295,
title = {Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles},
author = {N Scalacci and G W Black and G Mattedi and N L Brown and N J Turner and D Castagnolo},
doi = {10.1021/acscatal.6b03081},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {2},
pages = {1295-1300},
keywords = {},
pubstate = {published},
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@article{Yan20171408,
title = {Real-time screening of biocatalysts in live bacterial colonies},
author = {C Yan and F Parmeggiani and E A Jones and E Claude and S A Hussain and N J Turner and S L Flitsch and P E Barran},
doi = {10.1021/jacs.6b12165},
year = {2017},
date = {2017-01-01},
journal = {Journal of the American Chemical Society},
volume = {139},
number = {4},
pages = {1408-1411},
keywords = {},
pubstate = {published},
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@article{France2017710,
title = {Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways},
author = {S P France and L J Hepworth and N J Turner and S L Flitsch},
doi = {10.1021/acscatal.6b02979},
year = {2017},
date = {2017-01-01},
journal = {ACS Catalysis},
volume = {7},
number = {1},
pages = {710-724},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Hönig20178942,
title = {Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis},
author = {M Hönig and P Sondermann and N J Turner and E M Carreira},
doi = {10.1002/anie.201612462},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {31},
pages = {8942-8973},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Tavanti20179790,
title = {A biocatalytic cascade for the amination of unfunctionalised cycloalkanes},
author = {M Tavanti and J Mangas-Sanchez and S L Montgomery and M P Thompson and N J Turner},
doi = {10.1039/c7ob02569f},
year = {2017},
date = {2017-01-01},
journal = {Organic and Biomolecular Chemistry},
volume = {15},
number = {46},
pages = {9790-9793},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@book{Hutchings20171,
title = {Modern developments in catalysis},
author = {G Hutchings and M Davidson and R Catlow and C Hardacre and N Turner and P Collier},
doi = {10.1142/q0035},
year = {2017},
date = {2017-01-01},
journal = {Modern Developments in Catalysis},
pages = {1-320},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
@article{Galman2017361,
title = {Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases},
author = {J L Galman and I Slabu and N J Weise and C Iglesias and F Parmeggiani and R C Lloyd and N J Turner},
doi = {10.1039/c6gc02102f},
year = {2017},
date = {2017-01-01},
journal = {Green Chemistry},
volume = {19},
number = {2},
pages = {361-366},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Weissenborn2017742,
title = {Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors},
author = {M J Weissenborn and D P Debecker and S Golten and B Linclau and N J Turner and S L Flitsch},
doi = {10.2174/0929866524666170724114348},
year = {2017},
date = {2017-01-01},
journal = {Protein and Peptide Letters},
volume = {24},
number = {8},
pages = {742-746},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Aslan201747,
title = {Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3 -) to formate},
author = {A S Aslan and J Valjakka and J Ruupunen and D Yildirim and N J Turner and O Turunen and B Binay},
doi = {10.1093/protein/gzw062},
year = {2017},
date = {2017-01-01},
journal = {Protein engineering, design & selection : PEDS},
volume = {30},
number = {1},
pages = {47-55},
keywords = {},
pubstate = {published},
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@article{Montgomery201710491,
title = {Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing},
author = {S L Montgomery and J Mangas-Sanchez and M P Thompson and G A Aleku and B Dominguez and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025447057&doi=10.1002%2fanie.201705848&partnerID=40&md5=eed24e7ae2f636451659a45758dd448d},
doi = {10.1002/anie.201705848},
year = {2017},
date = {2017-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {56},
number = {35},
pages = {10491-10494},
keywords = {},
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@article{Westley20176983,
title = {Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy},
author = {C Westley and H Fisk and Y Xu and K A Hollywood and A J Carnell and J Micklefield and N J Turner and R Goodacre},
doi = {10.1002/chem.201701388},
year = {2017},
date = {2017-01-01},
journal = {Chemistry - A European Journal},
volume = {23},
number = {29},
pages = {6983-6987},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{McKenna20174660,
title = {The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)},
author = {S M McKenna and P Mines and P Law and K Kovacs-Schreiner and W R Birmingham and N J Turner and S Leimkühler and A J Carnell},
doi = {10.1039/c7gc01696d},
year = {2017},
date = {2017-01-01},
journal = {Green Chemistry},
volume = {19},
number = {19},
pages = {4660-4665},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Ahmed20165468,
title = {Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination},
author = {S T Ahmed and F Parmeggiani and N J Weise and S L Flitsch and N J Turner},
doi = {10.1021/acs.orglett.6b02559},
year = {2016},
date = {2016-01-01},
journal = {Organic Letters},
volume = {18},
number = {21},
pages = {5468-5471},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{VanOosterwijk20164422,
title = {Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases},
author = {N Van Oosterwijk and S Willies and J Hekelaar and A C Terwisscha Van Scheltinga and N J Turner and B W Dijkstra},
doi = {10.1021/acs.biochem.6b00370},
year = {2016},
date = {2016-01-01},
journal = {Biochemistry},
volume = {55},
number = {31},
pages = {4422-4431},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Markošová201669,
title = {Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels},
author = {K Markošová and I Dolejš and R Stloukal and L Rios-Solis and M Rosenberg and M Micheletti and G J Lye and N J Turner and M Rebroš},
doi = {10.1016/j.molcatb.2016.04.009},
year = {2016},
date = {2016-01-01},
journal = {Journal of Molecular Catalysis B: Enzymatic},
volume = {129},
pages = {69-74},
keywords = {},
pubstate = {published},
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@article{Carbonell2016675,
title = {SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals},
author = {P Carbonell and A Currin and M Dunstan and D Fellows and A Jervis and N J W Rattray and C J Robinson and N Swainston and M Vinaixa and A Williams and C Yan and P Barran and R Breitling and G G -Q Chen and J -L Faulon and C Goble and R Goodacre and D B Kell and R L Feuvre and J Micklefield and N S Scrutton and P Shapira and E Takano and N J Turner},
doi = {10.1042/BST20160009},
year = {2016},
date = {2016-01-01},
journal = {Biochemical Society Transactions},
volume = {44},
number = {3},
pages = {675-677},
keywords = {},
pubstate = {published},
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@article{Westley20165898,
title = {Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts},
author = {C Westley and Y Xu and A J Carnell and N J Turner and R Goodacre},
doi = {10.1021/acs.analchem.6b00813},
year = {2016},
date = {2016-01-01},
journal = {Analytical Chemistry},
volume = {88},
number = {11},
pages = {5898-5903},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{France20163753,
title = {One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts},
author = {S P France and S Hussain and A M Hill and L J Hepworth and R M Howard and K R Mulholland and S L Flitsch and N J Turner},
doi = {10.1021/acscatal.6b00855},
year = {2016},
date = {2016-01-01},
journal = {ACS Catalysis},
volume = {6},
number = {6},
pages = {3753-3759},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aleku20163880,
title = {Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis},
author = {G A Aleku and H Man and S P France and F Leipold and S Hussain and L Toca-Gonzalez and R Marchington and S Hart and J P Turkenburg and G Grogan and N J Turner},
doi = {10.1021/acscatal.6b00782},
year = {2016},
date = {2016-01-01},
journal = {ACS Catalysis},
volume = {6},
number = {6},
pages = {3880-3889},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Aslan2016474,
title = {Semi-Rational Design of Geobacillus stearothermophilus L-Lactate Dehydrogenase to Access Various Chiral α-Hydroxy Acids},
author = {A S Aslan and W R Birmingham and N G Karagüler and N J Turner and B Binay},
doi = {10.1007/s12010-016-2007-x},
year = {2016},
date = {2016-01-01},
journal = {Applied Biochemistry and Biotechnology},
volume = {179},
number = {3},
pages = {474-484},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Yan20162351,
title = {Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry},
author = {C Yan and J W Schmidberger and F Parmeggiani and S A Hussain and N J Turner and S L Flitsch and P Barran},
doi = {10.1039/c6an00617e},
year = {2016},
date = {2016-01-01},
journal = {Analyst},
volume = {141},
number = {8},
pages = {2351-2355},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Slabu20161038,
title = {Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines},
author = {I Slabu and J L Galman and N J Weise and R C Lloyd and N J Turner},
doi = {10.1002/cctc.201600075},
year = {2016},
date = {2016-01-01},
journal = {ChemCatChem},
volume = {8},
number = {6},
pages = {1038-1042},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wells, A S; Wong, J W; Michels, P C; Entwistle, D A; Fandrick, K; Finch, G L; Goswami, A; Lee, H; Mix, S; Moody, T S; Pang, L; Sato, R K; Turner, N J; Watson, T J
@article{Wells2016594,
title = {Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form},
author = {A S Wells and J W Wong and P C Michels and D A Entwistle and K Fandrick and G L Finch and A Goswami and H Lee and S Mix and T S Moody and L Pang and R K Sato and N J Turner and T J Watson},
doi = {10.1021/acs.oprd.5b00369},
year = {2016},
date = {2016-01-01},
journal = {Organic Process Research and Development},
volume = {20},
number = {3},
pages = {594-601},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Eichler2016426,
title = {Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling},
author = {A Eichler and Ł Gricman and S Herter and P P Kelly and N J Turner and J Pleiss and S L Flitsch},
doi = {10.1002/cbic.201500536},
year = {2016},
date = {2016-01-01},
journal = {ChemBioChem},
volume = {17},
number = {5},
pages = {426-432},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Willies2016,
title = {A stereospecific solid-phase screening assay for colonies expressing both (R)-and (S)-selective Ω-Aminotransferases},
author = {S C Willies and J L Galman and I Slabu and N J Turner},
doi = {10.1098/rsta.2015.0084},
year = {2016},
date = {2016-01-01},
journal = {Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences},
volume = {374},
number = {2061},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Grogan20161900,
title = {InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines},
author = {G Grogan and N J Turner},
doi = {10.1002/chem.201503954},
year = {2016},
date = {2016-01-01},
journal = {Chemistry - A European Journal},
volume = {22},
number = {6},
pages = {1900-1907},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Both20161511,
title = {Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions},
author = {P Both and H Busch and P P Kelly and F G Mutti and N J Turner and S L Flitsch},
doi = {10.1002/anie.201510028},
year = {2016},
date = {2016-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {55},
number = {4},
pages = {1511-1513},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Heath2016117,
title = {Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles},
author = {R S Heath and M Pontini and S Hussain and N J Turner},
doi = {10.1002/cctc.201500822},
year = {2016},
date = {2016-01-01},
journal = {ChemCatChem},
volume = {8},
number = {1},
pages = {117-120},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Fisk201659,
title = {Achieving optimal SERS through enhanced experimental design},
author = {H Fisk and C Westley and N J Turner and R Goodacre},
doi = {10.1002/jrs.4855},
year = {2016},
date = {2016-01-01},
journal = {Journal of Raman Spectroscopy},
volume = {47},
number = {1},
pages = {59-66},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Roselló20165172,
title = {Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation},
author = {J M Roselló and S Staniland and N J Turner and J Clayden},
doi = {10.1016/j.tet.2016.01.037},
year = {2016},
date = {2016-01-01},
journal = {Tetrahedron},
volume = {72},
number = {34},
pages = {5172-5177},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20167256,
title = {Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes},
author = {F Parmeggiani and S T Ahmed and N J Weise and N J Turner},
doi = {10.1016/j.tet.2015.12.063},
year = {2016},
date = {2016-01-01},
journal = {Tetrahedron},
volume = {72},
number = {46},
pages = {7256-7262},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hugentobler20168064,
title = {Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor},
author = {K G Hugentobler and H Sharif and M Rasparini and R S Heath and N J Turner},
doi = {10.1039/c6ob01382a},
year = {2016},
date = {2016-01-01},
journal = {Organic and Biomolecular Chemistry},
volume = {14},
number = {34},
pages = {8064-8067},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Rowles20167343,
title = {Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids},
author = {I Rowles and B Groenendaal and B Binay and K J Malone and S C Willies and N J Turner},
doi = {10.1016/j.tet.2016.06.026},
year = {2016},
date = {2016-01-01},
journal = {Tetrahedron},
volume = {72},
number = {46},
pages = {7343-7347},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise20164086,
title = {Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source},
author = {N J Weise and S T Ahmed and F Parmeggiani and E Siirola and A Pushpanath and U Schell and N J Turner},
doi = {10.1039/c6cy00855k},
year = {2016},
date = {2016-01-01},
journal = {Catalysis Science and Technology},
volume = {6},
number = {12},
pages = {4086-4089},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20163298,
title = {Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase},
author = {F Parmeggiani and S T Ahmed and M P Thompson and N J Weise and J L Galman and D Gahloth and M S Dunstan and D Leys and N J Turner},
doi = {10.1002/adsc.201600682},
year = {2016},
date = {2016-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {358},
number = {20},
pages = {3298-3306},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weissenborn20166158,
title = {Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s},
author = {M J Weissenborn and S Notonier and S -L Lang and K B Otte and S Herter and N J Turner and S L Flitsch and B Hauer},
doi = {10.1039/c6cc01749e},
year = {2016},
date = {2016-01-01},
journal = {Chemical Communications},
volume = {52},
number = {36},
pages = {6158-6161},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Staniland201610755,
title = {Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts},
author = {S Staniland and R W Adams and J J W McDouall and I Maffucci and A Contini and D M Grainger and N J Turner and J Clayden},
doi = {10.1002/anie.201605486},
year = {2016},
date = {2016-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {55},
number = {36},
pages = {10755-10759},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{deGraaff20161555,
title = {Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer},
author = {C de Graaff and B Oppelaar and O Péruch and C M L Vande Velde and B Bechi and N J Turner and E Ruijter and R V A Orru},
doi = {10.1002/adsc.201600038},
year = {2016},
date = {2016-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {358},
number = {10},
pages = {1555-1560},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Özgün2015212,
title = {Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum},
author = {G Özgün and N G Karagüler and O Turunen and N J Turner and B Binay},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944199017&doi=10.1016%2fj.molcatb.2015.09.014&partnerID=40&md5=21bd4f6a48f0fa3e44e411c155bd0e54},
doi = {10.1016/j.molcatb.2015.09.014},
year = {2015},
date = {2015-01-01},
journal = {Journal of Molecular Catalysis B: Enzymatic},
volume = {122},
pages = {212-217},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{ToftgaardPedersen20151580,
title = {Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols},
author = {A Toftgaard Pedersen and W R Birmingham and G Rehn and S J Charnock and N J Turner and J M Woodley},
doi = {10.1021/acs.oprd.5b00278},
year = {2015},
date = {2015-01-01},
journal = {Organic Process Research and Development},
volume = {19},
number = {11},
pages = {1580-1589},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{DeGraaff201514133,
title = {Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction},
author = {C De Graaff and L Bensch and S J Boersma and R C Cioc and M J Van Lint and E Janssen and N J Turner and R V A Orru and E Ruijter},
doi = {10.1002/anie.201507041},
year = {2015},
date = {2015-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {54},
number = {47},
pages = {14133-14136},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Weise201512977,
title = {The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids},
author = {N J Weise and F Parmeggiani and S T Ahmed and N J Turner},
doi = {10.1021/jacs.5b07326},
year = {2015},
date = {2015-01-01},
journal = {Journal of the American Chemical Society},
volume = {137},
number = {40},
pages = {12977-12983},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Mutti20151525,
title = {Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades},
author = {F G Mutti and T Knaus and N S Scrutton and M Breuer and N J Turner},
doi = {10.1126/science.aac9283},
year = {2015},
date = {2015-01-01},
journal = {Science},
volume = {349},
number = {6255},
pages = {1525-1529},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Kelly20151713,
title = {Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions},
author = {P P Kelly and A Eichler and S Herter and D C Kranz and N J Turner and S L Flitsch},
doi = {10.3762/bjoc.11.186},
year = {2015},
date = {2015-01-01},
journal = {Beilstein Journal of Organic Chemistry},
volume = {11},
pages = {1713-1720},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ahmed20155410,
title = {Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation},
author = {S T Ahmed and F Parmeggiani and N J Weise and S L Flitsch and N J Turner},
doi = {10.1021/acscatal.5b01132},
year = {2015},
date = {2015-01-01},
journal = {ACS Catalysis},
volume = {5},
number = {9},
pages = {5410-5413},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Herter20152313,
title = {Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis},
author = {S Herter and S M McKenna and A R Frazer and S Leimkühler and A J Carnell and N J Turner},
doi = {10.1002/cctc.201500218},
year = {2015},
date = {2015-01-01},
journal = {ChemCatChem},
volume = {7},
number = {15},
pages = {2313-2317},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{McKenna20153271,
title = {Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem},
author = {S M McKenna and S Leimkühler and S Herter and N J Turner and A J Carnell},
doi = {10.1039/c5gc00707k},
year = {2015},
date = {2015-01-01},
journal = {Green Chemistry},
volume = {17},
number = {6},
pages = {3271-3275},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Man20151052,
title = {Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline},
author = {H Man and E Wells and S Hussain and Dr. Leipold F. and S Hart and Dr. Turkenburg J.P. and Prof. Dr. Turner N.J. and G Grogan},
doi = {10.1002/cbic.201402625},
year = {2015},
date = {2015-01-01},
journal = {ChemBioChem},
volume = {16},
number = {7},
pages = {1052-1059},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Faber20151565,
title = {Engineering biocatalysts for synthesis including cascade processes},
author = {K Faber and W -D Fessner and N J Turner},
doi = {10.1002/adsc.201500450},
year = {2015},
date = {2015-01-01},
journal = {Advanced Synthesis and Catalysis},
volume = {357},
number = {8},
pages = {1565-1566},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Parmeggiani20154608,
title = {Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process},
author = {F Parmeggiani and S L Lovelock and N J Weise and S T Ahmed and N J Turner},
doi = {10.1002/anie.201410670},
year = {2015},
date = {2015-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {54},
number = {15},
pages = {4608-4611},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Knaus2015223,
title = {Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes},
author = {T Knaus and F G Mutti and L D Humphreys and N J Turner and N S Scrutton},
doi = {10.1039/c4ob02282c},
year = {2015},
date = {2015-01-01},
journal = {Organic and Biomolecular Chemistry},
volume = {13},
number = {1},
pages = {223-233},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hussain2015579,
title = {An (R)-imine reductase biocatalyst for the asymmetric reduction of cyclic imines},
author = {S Hussain and F Leipold and H Man and E Wells and S P France and K R Mulholland and G Grogan and N J Turner},
doi = {10.1002/cctc.201402797},
year = {2015},
date = {2015-01-01},
journal = {ChemCatChem},
volume = {7},
number = {4},
pages = {579-583},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Bechi20144524,
title = {Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis},
author = {B Bechi and S Herter and S McKenna and C Riley and S Leimkühler and N J Turner and A J Carnell},
doi = {10.1039/c4gc01321b},
year = {2014},
date = {2014-01-01},
journal = {Green Chemistry},
volume = {16},
number = {10},
pages = {4524-4529},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Staniland201413084,
title = {Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers},
author = {S Staniland and B Yuan and N Giménez-Agullõ and T Marcelli and S C Willies and D M Grainger and N J Turner and J Clayden},
doi = {10.1002/chem.201404509},
year = {2014},
date = {2014-01-01},
journal = {Chemistry - A European Journal},
volume = {20},
number = {41},
pages = {13084-13088},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Scheller20142201,
title = {Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases},
author = {P N Scheller and S Fademrecht and S Hofelzer and J Pleiss and F Leipold and N J Turner and B M Nestl and B Hauer},
doi = {10.1002/cbic.201402213},
year = {2014},
date = {2014-01-01},
journal = {ChemBioChem},
volume = {15},
number = {15},
pages = {2201-2204},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Schrittwieser20143657,
title = {Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants},
author = {J H Schrittwieser and B Groenendaal and S C Willies and D Ghislieri and I Rowles and V Resch and J H Sattler and E -M Fischereder and B Grischek and W -D Lienhart and N J Turner and W Kroutil},
doi = {10.1039/c4cy00642a},
year = {2014},
date = {2014-01-01},
journal = {Catalysis Science and Technology},
volume = {4},
number = {10},
pages = {3657-3664},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Green201410714,
title = {Chiral amine synthesis using ω-transaminases: An amine donor that displaces equilibria and enables high-throughput screening},
author = {A P Green and N J Turner and E O'Reilly},
doi = {10.1002/anie.201406571},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {40},
pages = {10714-10717},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@book{Humphrey2014123,
title = {Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions},
author = {C E Humphrey and M Ahmed and A Ghanem and N J Turner},
doi = {10.1002/9783527650880.ch4},
year = {2014},
date = {2014-01-01},
journal = {Separation of Enantiomers: Synthetic Methods},
volume = {9783527330454},
pages = {123-160},
keywords = {},
pubstate = {published},
tppubtype = {book}
}
@article{Lovelock20144652,
title = {Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway},
author = {S L Lovelock and R C Lloyd and N J Turner},
doi = {10.1002/anie.201311061},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {18},
pages = {4652-4656},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Schrittwieser20143731,
title = {Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion},
author = {J H Schrittwieser and B Groenendaal and V Resch and D Ghislieri and S Wallner and E -M Fischereder and E Fuchs and B Grischek and J H Sattler and P MacHeroux and N J Turner and W Kroutil},
doi = {10.1002/anie.201400027},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {14},
pages = {3731-3734},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Ghislieri2014284,
title = {Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines},
author = {D Ghislieri and N J Turner},
doi = {10.1007/s11244-013-0184-1},
year = {2014},
date = {2014-01-01},
journal = {Topics in Catalysis},
volume = {57},
number = {5},
pages = {284-300},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Turner2014283,
title = {Foreword},
author = {N J Turner and J Whittall and T R Ward},
doi = {10.1007/s11244-013-0186-z},
year = {2014},
date = {2014-01-01},
journal = {Topics in Catalysis},
volume = {57},
number = {5},
pages = {283},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{O'Reilly20142447,
title = {A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines},
author = {E O'Reilly and C Iglesias and D Ghislieri and J Hopwood and J L Galman and R C Lloyd and N J Turner},
doi = {10.1002/anie.201309208},
year = {2014},
date = {2014-01-01},
journal = {Angewandte Chemie - International Edition},
volume = {53},
number = {9},
pages = {2447-2450},
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@book{Turner2014328,
title = {A Reduction of C N to CH-NH Using Enzymes and Microorganisms},
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@article{Heath2014996,
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@article{O'Reilly2014992,
title = {Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines},
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@article{Heap20142251,
title = {Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification},
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@article{Zajkoska20141229,
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date = {2014-01-01},
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@article{Ghislieri20132869,
title = {Monoamine oxidase (MAO-N) catalyzed deracemization of tetrahydro-β- carbolines: Substrate dependent switch in enantioselectivity},
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@article{Leipold20133505,
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@article{Ghislieri201310863,
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@article{Rodríguez-Mata20131372,
title = {Structure and activity of NADPH-dependent reductase Q1EQE0 from streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate},
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@article{O'Reilly20131490,
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@book{Turner201363,
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@article{Turner2013212,
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@article{Köhler201393,
title = {Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes},
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@article{KalimAkhtara201387,
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@article{Willies20127564,
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@article{Rowles20121259,
title = {Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea},
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@article{March-Cortijos20121511,
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@article{O'Reilly2012496,
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@article{Znabet2012941,
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@article{Foulkes20111589,
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@article{Robin20111494,
title = {Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope},
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@article{Ioannou201111228,
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@article{Oneill20111014,
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@article{Fessner20112189,
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@article{Walker2011,
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author = {R G Walker and G Thomson and K Malone and M W Nowicki and E Brown and D G Blake and N J Turner and M D Walkinshaw and K M Grant and J C Mottram},
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title = {Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans},
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@article{O'Reilly20112490,
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@article{Hopwood2011773,
title = {A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases},
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@article{Znabet20107918,
title = {A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions},
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@article{Znabet20107706,
title = {Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence},
author = {A Znabet and J Zonneveld and E Janssen and F J J De Kanter and M Helliwell and N J Turner and E Ruijter and R V A Orru},
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title = {Selective chemical intervention in the proteome of caenorhabditis elegans},
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@article{Yuan20107010,
title = {Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases},
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journal = {Angewandte Chemie - International Edition},
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@article{Znabet20105289,
title = {Highly stereoselective synthesis of substituted prolyl peptides using a combination of biocatalytic desymmetrization and multicomponent reactions},
author = {A Znabet and E Ruijter and F J J De Kanter and V Köhler and M Helliwell and N J Turner and R V A Orru},
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title = {Enantioselective biocatalytic oxidative desymmetrization of substituted pyrrolidines},
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title = {Efficient production of enantiomerically pure chiral amines at concentrations of 50 g/L using transaminases},
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title = {Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme},
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title = {Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase},
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title = {Rapid screening and scale-up of transaminase catalysed reactions},
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title = {The Structure of Monoamine Oxidase from Aspergillus niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution},
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title = {Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis},
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title = {Rapid determination of both the activity and enantioselectivity of ketoreductases},
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title = {Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans},
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title = {A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A},
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title = {Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst},
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title = {Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp.},
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@article{Fotheringham2006287,
title = {Preparative deracemization of unnatural amino acids},
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title = {A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines},
author = {C J Dunsmore and R Carr and T Fleming and N J Turner},
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title = {A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A},
author = {M A Wear and A Patterson and K Malone and C Dunsmore and N J Turner and M D Walkinshaw},
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@article{Çelik20052930,
title = {Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes},
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@article{Çelik20052688,
title = {Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium},
author = {A Çelik and D Sperandio and R E Speight and N J Turner},
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@article{Çelik20053652,
title = {Identification of broad specificity P450CAM variants by primary screening against indole as substrate},
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@article{Hunter20052215,
title = {Analysis of the domain properties of the novel cytochrome P450 RhF},
author = {D J B Hunter and G A Roberts and T W B Ost and J H White and S Müller and N J Turner and S L Flitsch and S K Chapman},
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@article{Carr2005637,
title = {Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines},
author = {R Carr and M Alexeeva and M J Dawson and V Gotor-Fernández and C E Humphrey and N J Turner},
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@article{Poondra20046920,
title = {Efficient palladium-catalyzed cross-coupling of β-chloroalkylidene/ arylidene malonates using microwave chemistry},
author = {R R Poondra and P M Fischer and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-4644308022&doi=10.1021%2fjo049132r&partnerID=40&md5=5ebbde6615e8d36a8a2b469fb52a1f99},
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year = {2004},
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journal = {Journal of Organic Chemistry},
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number = {20},
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title = {Rapid identification of cytochrome P450 cam variants by in vivo screening of active site libraries},
author = {R E Speight and F E Hancock and C Winkel and H S Bevinakatti and M Sarkar and S L Flitsch and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-4644247822&doi=10.1016%2fj.tetasy.2004.06.053&partnerID=40&md5=88f8fe2e00f949b5f1b8b7fcf6eb2ffd},
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@article{Moore20041133,
title = {Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering},
author = {B D Moore and L Stevenson and A Watt and S Flitsch and N J Turner and C Cassidy and D Graham},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-4444346508&doi=10.1038%2fnbt1003&partnerID=40&md5=04b4e7fee09eb8c503510123e0a40849},
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journal = {Nature Biotechnology},
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number = {9},
pages = {1133-1138},
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@article{Humphrey20041144,
title = {Dimedone esters as novel hydrolase substrates and their application in the colorimetric detection of lipase and esterase activity},
author = {C E Humphrey and M A M Easson and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-4544225529&doi=10.1002%2fcbic.200400027&partnerID=40&md5=775d2dc07b577dd2d8d7a10b490045d5},
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@article{Roff20044098,
title = {A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids},
author = {G J Roff and R C Lloyd and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842607456&doi=10.1021%2fja049499d&partnerID=40&md5=e8fbe0f401e3552b61a807a1d68e759b},
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journal = {Journal of the American Chemical Society},
volume = {126},
number = {13},
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@article{Roberts200496,
title = {Nucleotide sequence of a portion of the camphor-degrading gene cluster from Rhodococcus sp. NCIMB 9784},
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url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-2442665232&doi=10.1080%2f10425170310001656765&partnerID=40&md5=dfc8087d3831b55e216fe2e161960c7c},
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year = {2004},
date = {2004-01-01},
journal = {DNA Sequence - Journal of DNA Sequencing and Mapping},
volume = {15},
number = {2},
pages = {96-103},
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@article{Lins2004771,
title = {Generation of a dynamic combinatorial library using sialic acid aldolase and in situ screening against wheat germ agglutinin},
author = {R J Lins and S L Flitsch and N J Turner and E Irving and S A Brown},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0346964394&doi=10.1016%2fj.tet.2003.11.062&partnerID=40&md5=55a0dbe97f1b1b453fab804d871fe5fd},
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year = {2004},
date = {2004-01-01},
journal = {Tetrahedron},
volume = {60},
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@article{Alexeeva20034133,
title = {Directed evolution of enzymes: New biocatalysts for asymmetric synthesis},
author = {M Alexeeva and R Carr and N J Turner},
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@article{Humphrey200313952,
title = {Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy},
author = {C E Humphrey and N J Turner and M A M Easson and S L Flitsch and R V Ulijn},
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@article{Carr20034807,
title = {Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity},
author = {R Carr and M Alexeeva and A Enright and T S C Eve and M J Dawson and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0142214752&doi=10.1002%2fanie.200352100&partnerID=40&md5=3cb927b46849700694236160d78b0c26},
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date = {2003-01-01},
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@article{Humphrey2003849,
title = {Solid-supported cyclohexane-1,3-dione (CHD): A "capture and release" reagent for the synthesis of amides and novel scavenger resin},
author = {C E Humphrey and M A M Easson and J P Tierney and N J Turner},
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year = {2003},
date = {2003-01-01},
journal = {Organic Letters},
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@article{Hull2003567,
title = {Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations},
author = {J D Hull and F Scheinmann and N J Turner},
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@article{Enright20032636,
title = {Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation-reduction procedure},
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@article{Roberts200348914,
title = {A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center.},
author = {G A Roberts and A Celik and D J Hunter and T W Ost and J H White and S K Chapman and N J Turner and S L Flitsch},
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year = {2003},
date = {2003-01-01},
journal = {The Journal of biological chemistry},
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number = {49},
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@article{Grogan2002449,
title = {P450camr, a cytochrome P450 catalysing the stereospecific 6-endo-hydroxylation of (1R)-(+)-camphor},
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@article{Lins20023405,
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author = {R J Lins and S L Flitsch and N J Turner and E Irving and S A Brown},
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date = {2002-01-01},
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@article{Alexeeva20023177,
title = {Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution},
author = {M Alexeeva and A Enright and M J Dawson and M Mahmoudian and N J Turner},
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@article{Roberts20023898,
title = {Identification of a new class of cytochrome P450 from a Rhodococcus sp.},
author = {G A Roberts and G Grogan and A Greter and S L Flitsch and N J Turner},
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@article{Alexandre2002707,
title = {Amine-boranes: Effective reducing agents for the deracemisation of DL-amino acids using L-amino acid oxidase from Proteus myxofaciens},
author = {F -R Alexandre and D P Pantaleone and P P Taylor and I G Fotheringham and D J Ager and N J Turner},
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number = {4},
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title = {Biotechnology. Paper Alert.},
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date = {2002-01-01},
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number = {1},
pages = {1-8},
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@article{Quirós20015074,
title = {Tuning lipase enantioselectivity in organic media using solid-state buffers},
author = {M Quirós and M -C Parker and N J Turner},
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year = {2001},
date = {2001-01-01},
journal = {Journal of Organic Chemistry},
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number = {15},
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@article{Grogan200112565,
title = {The desymmetrization of bicyclic β-diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily},
author = {G Grogan and G A Roberts and D Bougioukou and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035918262&doi=10.1074%2fjbc.M011538200&partnerID=40&md5=c60fceef9fadd57bd450fea9e07ef3b7},
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year = {2001},
date = {2001-01-01},
journal = {Journal of Biological Chemistry},
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number = {16},
pages = {12565-12572},
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title = {An asymmetric enzyme-catalyzed retro-claisen reaction for the desymmetrization of cyclic β-diketones},
author = {G Grogan and J Graf and A Jones and S Parsons and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035857569&doi=10.1002%2f1521-3773%2820010316%2940%3a6%3c1111%3a%3aAID-ANIE11110%3e3.0.CO%3b2-2&partnerID=40&md5=d1400c418a159474707dee0f040cc977},
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year = {2001},
date = {2001-01-01},
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title = {Diastereoselective hydroxylation and reduction of derivatised tetrahydrofurans by Beauveria bassiana},
author = {G Grogan and J T Sime and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035132490&doi=10.1023%2fA%3a1010393216458&partnerID=40&md5=ab89f71faf84986eb41c70e1782c1bcd},
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date = {2001-01-01},
journal = {Biotechnology Letters},
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pages = {119-124},
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title = {Synthesis of a novel N-hydroxypyrrolidine using enzyme catalysed asymmetric carbon-carbon bond synthesis},
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url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034622066&doi=10.1016%2fS0040-4039%2800%2900645-6&partnerID=40&md5=3bc8b44c59b3a89b2c568bbc178fb08d},
doi = {10.1016/S0040-4039(00)00645-6},
year = {2000},
date = {2000-01-01},
journal = {Tetrahedron Letters},
volume = {41},
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title = {Dynamic kinetic resolution: Synthesis of optically active α-amino acid derivatives},
author = {S A Brown and M -C Parker and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034607765&doi=10.1016%2fS0957-4166%2800%2900108-7&partnerID=40&md5=60cec4638c91d9b1a10e33430b4c09a0},
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date = {2000-01-01},
journal = {Tetrahedron Asymmetry},
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number = {8},
pages = {1687-1690},
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title = {The enzymatic glucuronidation of 3-O-protected morphine - A new route to 7,8-dihydromorphine-6-glucuronide},
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year = {2000},
date = {2000-01-01},
journal = {Tetrahedron Asymmetry},
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title = {Carbon-carbon bond synthesis: The impact of rDNA technology on the production and use of E. coli transketolase},
author = {M D Lilly and R Chauhan and C French and M Gyamerah and G R Hobbs and A Humphrey and M Isupov and J A Littlechild and R K Mitra and K G Morris and M Rupprecht and N J Turner and J M Ward and A J Willetts and J M Woodley},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029945836&doi=10.1111%2fj.1749-6632.1996.tb40589.x&partnerID=40&md5=469573c9b3a2d818e8464629c06dd58c},
doi = {10.1111/j.1749-6632.1996.tb40589.x},
year = {1996},
date = {1996-01-01},
journal = {Annals of the New York Academy of Sciences},
volume = {782},
pages = {513-525},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Roussel1995933,
title = {Synthesis of shidasterone and the unambiguous determination of its configuration at C-22},
author = {P G Roussel and N J Turner and L N Dinan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0342662309&doi=10.1039%2fC39950000933&partnerID=40&md5=6878922b5c2dc428214da56145bc63cb},
doi = {10.1039/C39950000933},
year = {1995},
date = {1995-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {9},
pages = {933-934},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Humphrey19952475,
title = {Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: Novel substrates for Escherichia coli transketolase},
author = {A J Humphrey and N J Turner and R McCague and S J C Taylor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049072050&doi=10.1039%2fC39950002475&partnerID=40&md5=fd3678e1f73bb3a53bc860a72984ac20},
doi = {10.1039/C39950002475},
year = {1995},
date = {1995-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {24},
pages = {2475-2476},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Stock19952063,
title = {N-(2-carboxybenzoyl)-L-phenylalanylglycine: A low molecular-mass gelling agent},
author = {H T Stock and N J Turner and R McCague},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049088306&doi=10.1039%2fC39950002063&partnerID=40&md5=999528dc2027bdda9b9bd3c9355303ab},
doi = {10.1039/C39950002063},
year = {1995},
date = {1995-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {20},
pages = {2063-2064},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Littlechild19951074,
title = {Crystallization and preliminary X-ray crystallographic data with Escherichia coli transketolase},
author = {J Littlechild and N Turner and G Hobbs and M Lilly and A Rawas and H Watson},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029199270&doi=10.1107%2fS0907444995005415&partnerID=40&md5=2f424cbe6c9d88ea361391674806fbfa},
doi = {10.1107/S0907444995005415},
year = {1995},
date = {1995-01-01},
journal = {Acta Crystallographica Section D: Biological Crystallography},
volume = {51},
number = {6},
pages = {1074-1076},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Brown19951117,
title = {Synthesis of morphine-6-glucuronide via a highly selective enzyme catalysed hydrolysis reaction},
author = {R T Brown and N E Carter and F Scheinmann and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028891801&doi=10.1016%2f0040-4039%2894%2902409-5&partnerID=40&md5=c289b58c4739a311228ba5a2385e6d98},
doi = {10.1016/0040-4039(94)02409-5},
year = {1995},
date = {1995-01-01},
journal = {Tetrahedron Letters},
volume = {36},
number = {7},
pages = {1117-1120},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Turner19951113,
title = {Synthesis of homochiral l-(S)-tert-leucine via a lipase catalysed dynamic resolution process},
author = {N J Turner and J R Winterman and R McCague and J S Parratt and S J C Taylor},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028891799&doi=10.1016%2f0040-4039%2894%2902408-4&partnerID=40&md5=72a2d35f4976140951ad742d1084143e},
doi = {10.1016/0040-4039(94)02408-4},
year = {1995},
date = {1995-01-01},
journal = {Tetrahedron Letters},
volume = {36},
number = {7},
pages = {1113-1116},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hill19955391,
title = {Revised Pathway for the Biosynthesis of Aristeromycin and Neplanocin A from D-Glucose in Streptomyces citricolor},
author = {J M Hill and G N Jenkins and N J Turner and C P Rush and A J Willetts and A D Buss and M J Dawson and B A M Rudd},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029031673&doi=10.1021%2fja00124a035&partnerID=40&md5=ceb6da5b9a07dc80d615c8641681c9f1},
doi = {10.1021/ja00124a035},
year = {1995},
date = {1995-01-01},
journal = {Journal of the American Chemical Society},
volume = {117},
number = {19},
pages = {5391-5392},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Crosby19941679,
title = {Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst},
author = {J Crosby and J Moilliet and J S Parratt and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049083979&partnerID=40&md5=f168374fe7398a30fe381824a839b7ae},
year = {1994},
date = {1994-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {13},
pages = {1679-1687},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hill19941483,
title = {Preparation of neplanocin-A from D-ribose and by a chemoenzymic method},
author = {J M Hill and E J Hutchinson and D M Le Grand and S M Roberts and A J Thorpe and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049078947&partnerID=40&md5=0acd57425fe0ea1f8e15f60108e2c8e8},
year = {1994},
date = {1994-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {11},
pages = {1483-1487},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Davey19947867,
title = {Regioselective reduction of substituted dinitroarenes using baker's yeast},
author = {C L Davey and L W Powell and N J Turner and A Wells},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028020841&doi=10.1016%2f0040-4039%2894%2980139-8&partnerID=40&md5=e5f1ffc28cc924e6bf2d82acc02977c1},
doi = {10.1016/0040-4039(94)80139-8},
year = {1994},
date = {1994-01-01},
journal = {Tetrahedron Letters},
volume = {35},
number = {42},
pages = {7867-7870},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baker19942517,
title = {An improved strategy for the stereoselective synthesis of glycosides using glycosidases as catalysts},
author = {A Baker and N J Turner and M C Webberley},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028020320&doi=10.1016%2fS0957-4166%2800%2980398-5&partnerID=40&md5=2ad61ff0582636b6e941e24e8e807129},
doi = {10.1016/S0957-4166(00)80398-5},
year = {1994},
date = {1994-01-01},
journal = {Tetrahedron: Asymmetry},
volume = {5},
number = {12},
pages = {2517-2522},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Kerridge1994447,
title = {Microbial hydrolysis of glutaronitrile derivatives with brevibacterium sp. R 312},
author = {A Kerridge and J S Parratt and S M Roberts and F Theil and N J Turner and A J Willetts},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028457954&doi=10.1016%2f0968-0896%2894%2980014-6&partnerID=40&md5=991a96529b2a8dce8e6c5cfbe21a9bb3},
doi = {10.1016/0968-0896(94)80014-6},
year = {1994},
date = {1994-01-01},
journal = {Bioorganic and Medicinal Chemistry},
volume = {2},
number = {6},
pages = {447-455},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Pallanca19933017,
title = {Chemo-enzymic synthesis of guanosine 5′-diphosphomannose (GDP-mannose) and selected analogues},
author = {J E Pallanca and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049070955&partnerID=40&md5=b67c24dc791422cf9cea58bb07fd8f64},
year = {1993},
date = {1993-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {23},
pages = {3017-3022},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Brackenridge19931093,
title = {Enzymatic resolution of oxalate esters of a tertiary alcohol using porcine pancreatic lipase},
author = {I Brackenridge and R McCague and S M Roberts and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049087848&partnerID=40&md5=ae21ef3d6619b21e093f464b170435be},
year = {1993},
date = {1993-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {10},
pages = {1093-1094},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Hobbs1993165,
title = {Enzyme-catalysed carbon-carbon bond formation: Use of transketolase from Escherichia coli},
author = {G R Hobbs and M D Lilly and N J Turner and J M Ward and A J Willets and J M Woodley},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049067656&partnerID=40&md5=b183acd368303dc88853756c0c7befeb},
year = {1993},
date = {1993-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {2},
pages = {165-166},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Roberts19934083,
title = {The isolation and absolute configuration of (1S,2S,3R)-4- Hydroxymethylcyclopent-4-ene-1,2,3-triol: A putative intermediate in the biosynthesis of aristeromycin by Streptomyces citricolor},
author = {S M Roberts and A J Thorpe and N J Turner and W M Blows and A D Buss and M J Dawson and D Noble and B A M Rudd and P J Sidebottom and W F Wall},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027299439&doi=10.1016%2fS0040-4039%2800%2960621-4&partnerID=40&md5=9f778a246276f8f42eba2683d9249db3},
doi = {10.1016/S0040-4039(00)60621-4},
year = {1993},
date = {1993-01-01},
journal = {Tetrahedron Letters},
volume = {34},
number = {25},
pages = {4083-4086},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Wilson1993195,
title = {A novel mono-branched lipid phosphate acts as a substrate for dolichyl phosphate mannose synthetase},
author = {I B H Wilson and J P Taylor and M C Webberley and N J Turner and S L Flitsch},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027500899&doi=10.1042%2fbj2950195&partnerID=40&md5=3ee57829314f1876a19956bc8be95079},
doi = {10.1042/bj2950195},
year = {1993},
date = {1993-01-01},
journal = {Biochemical Journal},
volume = {295},
number = {1},
pages = {195-201},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Beard19931085,
title = {Stereoselective hydrolysis of nitriles and amides under mild conditions using a whole cell catalyst},
author = {T Beard and M A Cohen and J S Parratt and N J Turner and J Crosby and J Moilliet},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027159507&doi=10.1016%2fS0957-4166%2800%2980215-3&partnerID=40&md5=39d59e135b20e3e0d026f1270553c8c2},
doi = {10.1016/S0957-4166(00)80215-3},
year = {1993},
date = {1993-01-01},
journal = {Tetrahedron: Asymmetry},
volume = {4},
number = {6},
pages = {1085-1104},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Floyd19921085,
title = {A simple strategy for obtaining both enantiomers from an aldolase reaction: Preparation of L- and D-4-hydroxy-2-ketoglutarate},
author = {N C Floyd and M H Liebster and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049090311&partnerID=40&md5=acd6c4d7eeb6bbe602f2f45ff4b74be5},
year = {1992},
date = {1992-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {9},
pages = {1085-1086},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Flitsch19922087,
title = {Chemo-enzymatic synthesis of a lipid-linked core trisaccharide of N-linked glycoproteins},
author = {S L Flitsch and H L Pinches and J P Taylor and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049081808&partnerID=40&md5=d664880c09f9b1ac31322eeb7311f146},
year = {1992},
date = {1992-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {16},
pages = {2087-2093},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Chinn1992661,
title = {Regioselective enzymatic acetylation of methyl 4,6-O-benzylidene-α- and β-D-glucopyranoside},
author = {M J Chinn and G Iacazio and D G Spackman and N J Turner and S M Roberts},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049066543&partnerID=40&md5=bda086758a81aef4802fb5cfcc347c68},
year = {1992},
date = {1992-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {6},
pages = {661-662},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Chinn19922045,
title = {Erratum: Regioselective enzymatic acetylation of methyl 4,6-O-benzylidene-α- and β-D-glucopyranoside (Journal of the Chemical Society, Perkin Transactions 1 (1992), (661))},
author = {M J Chinn and G Iacazio and D G Spackman and N J Turner and S M Roberts},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049075750&partnerID=40&md5=25685aca9c7c8b88a3e197d0886078b9},
year = {1992},
date = {1992-01-01},
journal = {Journal of the Chemical Society, Perkin Transactions 1},
number = {15},
pages = {2045},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Roberts1992227,
title = {Some recent developments in the use of enzyme catalysed reactions in organic synthesis},
author = {S M Roberts and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026565323&doi=10.1016%2f0168-1656%2892%2990143-W&partnerID=40&md5=bcce1c1f914c0876f2c5e225d4032e92},
doi = {10.1016/0168-1656(92)90143-W},
year = {1992},
date = {1992-01-01},
journal = {Journal of Biotechnology},
volume = {22},
number = {3},
pages = {227-244},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Cohen19921543,
title = {Enantioselective hydrolysis of nitriles and amides using an immobilised whole cell system},
author = {M A Cohen and J S Parratt and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026677853&doi=10.1016%2fS0957-4166%2800%2986056-5&partnerID=40&md5=82864902a257c739d37f2bdd1de064b8},
doi = {10.1016/S0957-4166(00)86056-5},
year = {1992},
date = {1992-01-01},
journal = {Tetrahedron: Asymmetry},
volume = {3},
number = {12},
pages = {1543-1546},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19919881,
title = {Cephalosporin biosynthesis: A branched pathway sensitive to an isotope effect},
author = {J E Baldwin and R M Adlington and N P Crouch and C J Schofield and N J Turner and R T Aplin},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026045410&doi=10.1016%2fS0040-4020%2801%2980725-0&partnerID=40&md5=a26fda5575fda3a5194bb230b7627f45},
doi = {10.1016/S0040-4020(01)80725-0},
year = {1991},
date = {1991-01-01},
journal = {Tetrahedron},
volume = {47},
number = {47},
pages = {9881-9900},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Turner19911349,
title = {Stereospecific attachment of carbohydrates to amino acid derivatives using β-glucosidase and β-xylosidase},
author = {N J Turner and M C Webberley},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025914302&doi=10.1039%2fC39910001349&partnerID=40&md5=b9d6deab6cf540576a564683515e12ce},
doi = {10.1039/C39910001349},
year = {1991},
date = {1991-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {19},
pages = {1349-1350},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Flitsch1991380,
title = {Synthesis of a novel acceptor substrate for a mannosyl transferase},
author = {S L Flitsch and J P Taylor and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-7844240161&doi=10.1039%2fC39910000380&partnerID=40&md5=7ad148fe16fe7f795e15a2372cebb967},
doi = {10.1039/C39910000380},
year = {1991},
date = {1991-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {6},
pages = {380-382},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Flitsch1991382,
title = {Chemo-enzymatic synthesis of a β-mannosyl-containing trisaccharide},
author = {S L Flitsch and J P Taylor and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-10544250217&doi=10.1039%2fC39910000382&partnerID=40&md5=1ca252e1afabf3323891495c680aa08c},
doi = {10.1039/C39910000382},
year = {1991},
date = {1991-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {6},
pages = {382-384},
keywords = {},
pubstate = {published},
tppubtype = {article}
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@article{Baldwin19918223,
title = {Enzymic conversion of deuterated analogues of δ-l-α-aminoadipoyl-l-cysteinyl-d-allylglycine, an unnatural substrate for isopenicilin n synthase: A unified theory of second ring closure.},
author = {J E Baldwin and M Bradley and N J Turner and R M Adlington and A R Pitt and A E Derome},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025994422&doi=10.1016%2fS0040-4020%2801%2991016-6&partnerID=40&md5=29a0a9a70baa16eb38e81719141e3875},
doi = {10.1016/S0040-4020(01)91016-6},
year = {1991},
date = {1991-01-01},
journal = {Tetrahedron},
volume = {47},
number = {38},
pages = {8223-8242},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19918203,
title = {Synthesis of δ-L-α-aminoadipoyl-L-cysteinyl-D-allylglycine, and eight deuterated analogues, substrates for the investigation of the mechanism of action of isopenicillin n synthase.},
author = {J E Baldwin and M Bradley and N J Turner and R M Adlington and A R Pitt and H Sheridan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026045350&doi=10.1016%2fS0040-4020%2801%2991015-4&partnerID=40&md5=e35c72ccc1e5c79180b60feac000328f},
doi = {10.1016/S0040-4020(01)91015-4},
year = {1991},
date = {1991-01-01},
journal = {Tetrahedron},
volume = {47},
number = {38},
pages = {8203-8222},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Macfarlane199113,
title = {Some interesterification reactions involving mucor miehei lipase},
author = {E L A Macfarlane and F Rebolledo and S M Roberts and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0002591093&doi=10.3109%2f10242429109014851&partnerID=40&md5=a2d15eff3ada5cd940202ab902c289c1},
doi = {10.3109/10242429109014851},
year = {1991},
date = {1991-01-01},
journal = {Biocatalysis and Biotransformation},
volume = {5},
number = {1},
pages = {13-19},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin1991457,
title = {Further evidence for the involvement of a monocyclic β-lactam in the enzymatic conversion of δ-L-α-aminoadipoyl-L-cysteinyl-D-valine into isopenicillin N.},
author = {J E Baldwin and M Bradley and R M Adlington and W J Norris and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025968688&doi=10.1016%2fS0040-4020%2801%2990503-4&partnerID=40&md5=9f3297988308d48309353029de5ec2c8},
doi = {10.1016/S0040-4020(01)90503-4},
year = {1991},
date = {1991-01-01},
journal = {Tetrahedron},
volume = {47},
number = {3},
pages = {457-480},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{MacFarlane1990569,
title = {Enzyme-catalysed inter-esterification procedure for the preparation of esters of a chiral secondary alcohol in high enantiomeric purity},
author = {E L A MacFarlane and S M Roberts and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049085076&doi=10.1039%2fC39900000569&partnerID=40&md5=41a70d5ff702d779e3f9679af8aa01b7},
doi = {10.1039/C39900000569},
year = {1990},
date = {1990-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {7},
pages = {569-571},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Cohen19907223,
title = {Selective hydrolysis of nitriles under mild conditions by an enzyme.},
author = {M A Cohen and J Sawden and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025662001&doi=10.1016%2fS0040-4039%2800%2997285-X&partnerID=40&md5=06eaaa0ed18b0dca82d694e42f045639},
doi = {10.1016/S0040-4039(00)97285-X},
year = {1990},
date = {1990-01-01},
journal = {Tetrahedron Letters},
volume = {31},
number = {49},
pages = {7223-7226},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Turner1989624,
title = {A Combined Chemical—Enzymatic Synthesis of 3-Deoxy-D-arabino-heptulosonic Acid 7-Phosphate},
author = {N J Turner and G M Whitesides},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0001566797&doi=10.1021%2fja00184a033&partnerID=40&md5=dbe5581ea62bd4da27169af7b7b4f906},
doi = {10.1021/ja00184a033},
year = {1989},
date = {1989-01-01},
journal = {Journal of the American Chemical Society},
volume = {111},
number = {2},
pages = {624-627},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19891141,
title = {Cephalosporin C biosynthesis; stereochemistry of the incorporation of D,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C] valine into β-lactam compounds},
author = {J E Baldwin and R M Adlington and N P Crouch and N J Turner and C J Schofield},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024392685&doi=10.1039%2fC39890001141&partnerID=40&md5=2e88449c60872eb2d281c7e0ef175f8e},
doi = {10.1039/C39890001141},
year = {1989},
date = {1989-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {16},
pages = {1141-1143},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin1989978,
title = {Evidence for epoxide formation from isopenicillin N synthase},
author = {J E Baldwin and R M Adlington and M Bradley and N J Turner and A R Pitt},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049088151&doi=10.1039%2fC39890000978&partnerID=40&md5=ac80ed526f0e6b90283fe81003b1870b},
doi = {10.1039/C39890000978},
year = {1989},
date = {1989-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {15},
pages = {978-981},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin1989802,
title = {Penicillin biosynthesis: Active substrates derived by methoxy substitution in the valinyl residue of the natural substrate},
author = {J E Baldwin and R M Adlington and A Basak and P Imming and K Ponnamperuma and H Ronneberg and C J Schofield and H Ting and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024392313&doi=10.1039%2fC39890000802&partnerID=40&md5=af1335458b7abd1a982560766069cc30},
doi = {10.1039/C39890000802},
year = {1989},
date = {1989-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {12},
pages = {802-804},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19881125,
title = {Identification and characterisation of shunt metabolites from isopenicillin N synthase},
author = {J E Baldwin and R M Adlington and M Bradley and W J Norris and N J Turner and A Yoshida},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049080389&doi=10.1039%2fC39880001125&partnerID=40&md5=4928d5ee69fa45d15508c09c9f6f0370},
doi = {10.1039/C39880001125},
year = {1988},
date = {1988-01-01},
journal = {Journal of the Chemical Society, Chemical Transactions},
number = {16},
pages = {1125-1128},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19881125b,
title = {Identification and characterisation of shunt metabolites from isopenicillin N synthase},
author = {J E Baldwin and R M Adlington and M Bradley and W J Norris and N J Turner and A Yoshida},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023789386&doi=10.1039%2fc39880001125&partnerID=40&md5=f817859ad51287c144f6408e363287d9},
doi = {10.1039/c39880001125},
year = {1988},
date = {1988-01-01},
journal = {Journal of the Chemical Society - Series Chemical Communications},
number = {16},
pages = {1125-1128},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin1987652,
title = {Purification and characterization of cloned isopenicillin N synthetase},
author = {J E Baldwin and A J Pratt and J D Sutherland and N J Turner and M J Crabbe},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023180606&doi=10.7164%2fantibiotics.40.652&partnerID=40&md5=772235131cbb52691e86f6107dd0e732},
doi = {10.7164/antibiotics.40.652},
year = {1987},
date = {1987-01-01},
journal = {The Journal of Antibiotics},
volume = {40},
number = {5},
pages = {652-659},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin1986110,
title = {Stereospecificity of carbon-sulphur bond formation in penicillin biosynthesis},
author = {J E Baldwin and R M Adlington and B P Domayne-Hayman and H -H Ting and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022909108&doi=10.1039%2fC39860000110&partnerID=40&md5=30c1bcb2bbfb60b55f9f1c6fc83db728},
doi = {10.1039/C39860000110},
year = {1986},
date = {1986-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {2},
pages = {110-113},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19861305,
title = {Penicillin biosynthesis: The origin of hydroxy groups in β-lactams derived from unsaturated substrates},
author = {J E Baldwin and R M Adlington and S L Flitsch and H -H Ting and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022917323&doi=10.1039%2fC39860001305&partnerID=40&md5=8d962684c46982bfdb487d3107a7c78c},
doi = {10.1039/C39860001305},
year = {1986},
date = {1986-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {17},
pages = {1305-1308},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin1986975,
title = {Enzymatic synthesis of a new type of penicillin},
author = {J E Baldwin and R M Adlington and A Basak and S L Flitsch and S Petursson and N J Turner and H -H Ting},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022869537&doi=10.1039%2fC39860000975&partnerID=40&md5=74063d0835e546b188b79e0b377e4b2d},
doi = {10.1039/C39860000975},
year = {1986},
date = {1986-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {12},
pages = {975-976},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19841211,
title = {Penicillin biosynthesis: Multiple pathways from a modified substrate},
author = {J E Baldwin and R M Adlington and A E Derome and H -H Ting and N J Turner},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021151866&doi=10.1039%2fC39840001211&partnerID=40&md5=4cebffe66e4fe9cd354bd92e36af6250},
doi = {10.1039/C39840001211},
year = {1984},
date = {1984-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {18},
pages = {1211-1214},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
@article{Baldwin19841167,
title = {Penicillin biosynthesis: Enzymatic synthesis of new cephams},
author = {J E Baldwin and R M Adlington and N J Turner and B P Domayne-Hayman and H -H Ting and A E Derome and J A Murphy},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021233170&doi=10.1039%2fc39840001167&partnerID=40&md5=2b6c1821a562f5fb030d4a4de77e71a5},
doi = {10.1039/c39840001167},
year = {1984},
date = {1984-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {17},
pages = {1167-1170},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Baldwin, J E; Abraham, E P; Adlington, R M; Bahadur, G A; Chakravarti, B; Domayne-Hayman, B P; Field, L D; Flitsch, S L; Jayatilake, G S; Špakovskis, A; Ting, H -H; Turner, N J; White, R L; Usher, J J
@article{Baldwin19841225,
title = {Penicillin biosynthesis: Active site mapping with aminoadipoylcysteinylvaline variants},
author = {J E Baldwin and E P Abraham and R M Adlington and G A Bahadur and B Chakravarti and B P Domayne-Hayman and L D Field and S L Flitsch and G S Jayatilake and A Špakovskis and H -H Ting and N J Turner and R L White and J J Usher},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021210866&doi=10.1039%2fC39840001225&partnerID=40&md5=c6c15410e63f10712b2e1de3e70277c4},
doi = {10.1039/C39840001225},
year = {1984},
date = {1984-01-01},
journal = {Journal of the Chemical Society, Chemical Communications},
number = {18},
pages = {1225-1227},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
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