Weise, N J; Thapa, P; Ahmed, S T; Heath, R S; Parmeggiani, F; Turner, N J; Flitsch, S L

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines (Journal Article)

ChemCatChem, 2020.

(Links | BibTeX)

Tramontina, R; Galman, J L; Parmeggiani, F; Derrington, S R; Bugg, T D H; Turner, N J; Squina, F M; Dixon, N

Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass (Journal Article)

Green Chemistry, 22 (1), pp. 144-152, 2020.

(Links | BibTeX)

Thompson, M P; Derrington, S R; Heath, R S; Porter, J L; Mangas-Sanchez, J; Devine, P N; Truppo, M D; Turner, N J

A generic platform for the immobilisation of engineered biocatalysts (Journal Article)

Tetrahedron, 75 (3), pp. 327-334, 2019.

(Links | BibTeX)

Heath, R S; Birmingham, W R; Thompson, M P; Taglieber, A; Daviet, L; Turner, N J

An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols (Journal Article)

ChemBioChem, 20 (2), pp. 276-281, 2019.

(Links | BibTeX)

Thompson, M P; Peñafiel, I; Cosgrove, S C; Turner, N J

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals (Journal Article)

Organic Process Research and Development, 23 (1), pp. 9-18, 2019.

(Links | BibTeX)

Ramsden, J I; Heath, R S; Derrington, S R; Montgomery, S L; Mangas-Sanchez, J; Mulholland, K R; Turner, N J

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades (Journal Article)

Journal of the American Chemical Society, 141 (3), pp. 1201-1206, 2019.

(Links | BibTeX)

Megarity, C F; Siritanaratkul, B; Heath, R S; Wan, L; Morello, G; FitzPatrick, S R; Booth, R L; Sills, A J; Robertson, A W; Warner, J H; Turner, N J; Armstrong, F A

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores (Journal Article)

Angewandte Chemie - International Edition, 58 (15), pp. 4948-4952, 2019.

(Links | BibTeX)

Manning, J; Tavanti, M; Porter, J L; Kress, N; Visser, De S P; Turner, N J; Flitsch, S L

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S)-δ-Decalactone (Journal Article)

Angewandte Chemie - International Edition, 58 (17), pp. 5668-5671, 2019.

(Links | BibTeX)

Parmeggiani, F; Casamajo, Rué A; Walton, C J W; Galman, J L; Turner, N J; Chica, R A

One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase (Journal Article)

ACS Catalysis, 9 (4), pp. 3482-3486, 2019.

(Links | BibTeX)

Faber, K; Fessner, W -D; Turner, N J

Biocatalysis: Ready to Master Increasing Complexity (Journal Article)

Advanced Synthesis and Catalysis, 361 (11), pp. 2373-2376, 2019.

(Links | BibTeX)

Bornadel, A; Bisagni, S; Pushpanath, A; Montgomery, S L; Turner, N J; Dominguez, B

Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study (Journal Article)

Organic Process Research and Development, 23 (6), pp. 1262-1268, 2019.

(Links | BibTeX)

Currin, A; Kwok, J; Sadler, J C; Bell, E L; Swainston, N; Ababi, M; Day, P; Turner, N J; Kell, D B

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries (Journal Article)

ACS Synthetic Biology, 8 (6), pp. 1371-1378, 2019.

(Links | BibTeX)

Kimber, Richard L; Parmeggiani, Fabio; Joshi, Nimisha; Rakowski, Alexander M; Haigh, Sarah J; Turner, Nicholas J; Lloyd, Jonathan R

Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles (Journal Article)

Green Chem., 21 (15), pp. 4020-4024, 2019.

(Abstract | Links | BibTeX)

Parmeggiani, Fabio; Casamajo, Arnau Rué; Colombo, Danilo; Ghezzi, Maria Chiara; Galman, James Louis; Chica, Roberto A; Brenna, Elisabetta; Turner, Nicholas J

Biocatalytic retrosynthesis approaches to D-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin (Journal Article)

Green Chem., 21 (16), pp. 4368-4379, 2019.

(Links | BibTeX)

Mourelle-Insua, Ángela; Méndez-Sánchez, Daniel; Galman, James L; Slabu, Iustina; Turner, Nicholas J; Gotor-Fernández, Vicente; Lavandera, Iván

Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions (Journal Article)

Catal. Sci. Technol., 9 (15), pp. 4083-4090, 2019.

(Links | BibTeX)

Derrington, S R; Turner, N J; France, S P

Carboxylic acid reductases (CARs): An industrial perspective (Journal Article)

Journal of Biotechnology, 304 , pp. 78-88, 2019.

(Links | BibTeX)

Wan, Lei; Heath, Rachel S; Siritanaratkul, Bhavin; Megarity, Clare F; Sills, Adam J; Thompson, Matthew P; Turner, Nicholas J; Armstrong, Fraser A

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores (Journal Article)

Green Chem., 21 (18), pp. 4958-4963, 2019.

(Links | BibTeX)

Schnepel, C; Turner, N J

Identifying an iodinase (Journal Article)

Nature Chemistry, 11 (12), pp. 1076-1078, 2019.

(Links | BibTeX)

Hartley, C J; Williams, C C; Scoble, J A; Churches, Q I; North, A; French, N G; Nebl, T; Coia, G; Warden, A C; Simpson, G; Frazer, A R; Jensen, C N; Turner, N J; Scott, C

Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis (Journal Article)

Nature Catalysis, 2 (11), pp. 1006-1015, 2019.

(Links | BibTeX)

Mattey, A P; Birmingham, W R; Both, P; Kress, N; Huang, K; Munster, Van J M; Bulmer, G S; Parmeggiani, F; Voglmeir, J; Martinez, J E R; Turner, N J; Flitsch, S L

Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant (Journal Article)

ACS Catalysis, 9 (9), pp. 8208-8212, 2019.

(Links | BibTeX)

Lauder, Kate; Masci, Domiziana; Toscani, Anita; Mekdad, Aya Al; Black, Gary W; Brown, Nicola L; Turner, Nicholas J; Luisi, Renzo; Castagnolo, Daniele

A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution (Journal Article)

Org. Biomol. Chem., 17 , pp. 8982-8986, 2019.

(Abstract | Links | BibTeX)

Thorpe, T W; France, S P; Hussain, S; Marshall, J R; Zawodny, W; Mangas-Sanchez, J; Montgomery, S L; Howard, R M; Daniels, D S B; Kumar, R; Parmeggiani, F; Turner, N J

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles (Journal Article)

Journal of the American Chemical Society, 141 (49), pp. 19208-19213, 2019.

(Links | BibTeX)

Chen, F -F; Cosgrove, S C; Birmingham, W R; Mangas-Sanchez, J; Citoler, J; Thompson, M P; Zheng, G -W; Xu, J -H; Turner, N J

Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases (Journal Article)

ACS Catalysis, 9 (12), pp. 11813-11818, 2019.

(Links | BibTeX)

Citoler, Joan; Derrington, Sasha R; Galman, James L; Bevinakatti, Han; Turner, Nicholas J

A biocatalytic cascade for the conversion of fatty acids to fatty amines (Journal Article)

Green Chem., 21 , pp. 4932-4935, 2019.

(Links | BibTeX)

Odachowski, M; Greaney, M F; Turner, N J

Concurrent Biocatalytic Oxidation and C-C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines (Journal Article)

ACS Catalysis, 8 (11), pp. 10032-10035, 2018.

(Links | BibTeX)

Costa, B Z; Galman, J L; Slabu, I; France, S P; Marsaioli, A J; Turner, N J

Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts (Journal Article)

ChemCatChem, 10 (20), pp. 4733-4738, 2018.

(Links | BibTeX)

Toscani, A; Risi, C; Black, G W; Brown, N L; Shaaban, A; Turner, N J; Castagnolo, D

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines (Journal Article)

ACS Catalysis, 8 (9), pp. 8781-8787, 2018.

(Links | BibTeX)

Turner, N J

Enzymes team up with light-activated catalysts (Journal Article)

Nature, 560 (7718), pp. 310-311, 2018.

(Links | BibTeX)

Chapman, M R; Cosgrove, S C; Turner, N J; Kapur, N; Blacker, A J

Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen (Journal Article)

Angewandte Chemie - International Edition, 57 (33), pp. 10535-10539, 2018.

(Links | BibTeX)

Tavanti, M; Porter, J L; Levy, C W; Castellanos, Gómez J R; Flitsch, S L; Turner, N J

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s (Journal Article)

Biochemical and Biophysical Research Communications, 501 (4), pp. 846-850, 2018.

(Links | BibTeX)

Carbonell, P; Wong, J; Swainston, N; Takano, E; Turner, N J; Scrutton, N S; Kell, D B; Breitling, R; Faulon, J -L

Selenzyme: Enzyme selection tool for pathway design (Journal Article)

Bioinformatics, 34 (12), pp. 2153-2154, 2018.

(Links | BibTeX)

Cosgrove, S C; Hussain, S; Turner, N J; Marsden, S P

Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines (Journal Article)

ACS Catalysis, 8 (6), pp. 5570-5573, 2018.

(Links | BibTeX)

Porter, J L; Sabatini, S; Manning, J; Tavanti, M; Galman, J L; Turner, N J; Flitsch, S L

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope (Journal Article)

Enzyme and Microbial Technology, 113 , pp. 1-8, 2018.

(Links | BibTeX)

Slabu, I; Galman, J L; Iglesias, C; Weise, N J; Lloyd, R C; Turner, N J

n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones (Journal Article)

Catalysis Today, 306 , pp. 96-101, 2018.

(Links | BibTeX)

Birmingham, W R; Turner, N J

A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase (Journal Article)

ACS Catalysis, 8 (5), pp. 4025-4032, 2018.

(Links | BibTeX)

Çakar, M M; Mangas-Sanchez, J; Birmingham, W R; Turner, N J; Binay, B

Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii (Journal Article)

Preparative Biochemistry and Biotechnology, 48 (4), pp. 327-334, 2018.

(Links | BibTeX)

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Engineered ammonia lyases for the production of challenging electron-rich l -phenylalanines (Journal Article)

ACS Catalysis, 8 (4), pp. 3129-3132, 2018.

(Links | BibTeX)

Turner, N J; Kumar, R

Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis (Journal Article)

Current Opinion in Chemical Biology, 43 , pp. A1-A3, 2018.

(Links | BibTeX)

Weise, N J; Parmeggiani, F; Ahmed, S T; Turner, N J

Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis (Journal Article)

Topics in Catalysis, 61 (3-4), pp. 288-295, 2018.

(Links | BibTeX)

Herter, S; Medina, F; Wagschal, S; Benhaïm, C; Leipold, F; Turner, N J

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines (Journal Article)

Bioorganic and Medicinal Chemistry, 26 (7), pp. 1338-1346, 2018.

(Links | BibTeX)

Morrill, C; Jensen, C; Just-Baringo, X; Grogan, G; Turner, N J; Procter, D J

Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles (Journal Article)

Angewandte Chemie - International Edition, 57 (14), pp. 3692-3696, 2018.

(Links | BibTeX)

Kimber, R L; Lewis, E A; Parmeggiani, F; Smith, K; Bagshaw, H; Starborg, T; Joshi, N; Figueroa, A I; van der Laan, G; Cibin, G; Gianolio, D; Haigh, S J; Pattrick, R A D; Turner, N J; Lloyd, J R

Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry (Journal Article)

Small, 14 (10), 2018.

(Links | BibTeX)

Tavanti, M; Porter, J L; Sabatini, S; Turner, N J; Flitsch, S L

Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope (Journal Article)

ChemCatChem, 10 (5), pp. 1042-1051, 2018.

(Links | BibTeX)

Porter, J L; Manning, J; Sabatini, S; Tavanti, M; Turner, N J; Flitsch, S L

Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids (Journal Article)

ChemBioChem, 19 (5), pp. 513-520, 2018.

(Links | BibTeX)

Barley, M H; Turner, N J; Goodacre, R

Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins (Journal Article)

Journal of Chemical Information and Modeling, 58 (2), pp. 234-243, 2018.

(Links | BibTeX)

France, S P; Howard, R M; Steflik, J; Weise, N J; Mangas-Sanchez, J; Montgomery, S L; Crook, R; Kumar, R; Turner, N J

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination (Journal Article)

ChemCatChem, 10 (3), pp. 510-514, 2018.

(Links | BibTeX)

Aleku, G A; Mangas-Sanchez, J; Citoler, J; France, S P; Montgomery, S L; Heath, R S; Thompson, M P; Turner, N J

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase (Journal Article)

ChemCatChem, 10 (3), pp. 515-519, 2018.

(Links | BibTeX)

Walton, C J W; Parmeggiani, F; Barber, J E B; McCann, J L; Turner, N J; Chica, R A

Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades (Journal Article)

ChemCatChem, 10 (2), pp. 470-474, 2018.

(Links | BibTeX)

Hutchings, G J; Catlow, C R; Turner, N J

Providing sustainable catalytic solutions for a rapidly changing world (Journal Article)

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376 (2110), 2018.

(Links | BibTeX)

Aleku, G A; Nowicka, B; Turner, N J

Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones (Journal Article)

ChemCatChem, 10 (1), pp. 124-135, 2018.

(Links | BibTeX)

Galman, J L; Slabu, I; Parmeggiani, F; Turner, N J

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction (Journal Article)

Chemical Communications, 54 (80), pp. 11316-11319, 2018.

(Links | BibTeX)

Parmeggiani, F; Weise, N J; Ahmed, S T; Turner, N J

Synthetic and therapeutic applications of ammonia-lyases and aminomutases (Journal Article)

Chemical Reviews, 118 (1), pp. 73-118, 2018.

(Links | BibTeX)

Klumbys, E; Zebec, Z; Weise, N J; Turner, N J; Scrutton, N S

Bio-derived production of cinnamyl alcohol: Via a three step biocatalytic cascade and metabolic engineering (Journal Article)

Green Chemistry, 20 (3), pp. 658-663, 2018.

(Links | BibTeX)

Markošová, K; Camattari, A; Rosenberg, M; Glieder, A; Turner, N J; Rebroš, M

Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris (Journal Article)

Biotechnology Letters, 40 (1), pp. 127-133, 2018.

(Links | BibTeX)

Sharma, M; Mangas-Sanchez, J; France, S P; Aleku, G A; Montgomery, S L; Ramsden, J I; Turner, N J; Grogan, G

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases (Journal Article)

ACS Catalysis, pp. 11534-11541, 2018.

(Links | BibTeX)

Cosgrove, S C; Brzezniak, A; France, S P; Ramsden, J I; Mangas-Sanchez, J; Montgomery, S L; Heath, R S; Turner, N J

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications (Journal Article)

Methods in Enzymology, 608 , pp. 131-149, 2018.

(Links | BibTeX)

Batista, V F; Galman, J L; Pinto, D C; Silva, A M S; Turner, N J

Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization (Journal Article)

ACS Catalysis, 8 (12), pp. 11889-11907, 2018.

(Links | BibTeX)

Xu, J; Green, A P; Turner, N J

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles (Journal Article)

Angewandte Chemie - International Edition, 57 (51), pp. 16760-16763, 2018.

(Links | BibTeX)

Devine, P N; Howard, R M; Kumar, R; Thompson, M P; Truppo, M D; Turner, N J

Extending the application of biocatalysis to meet the challenges of drug development (Journal Article)

Nature Reviews Chemistry, 2 (12), pp. 409-421, 2018.

(Links | BibTeX)

Zawodny, W; Montgomery, S L; Marshall, J R; Finnigan, J D; Turner, N J; Clayden, J

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement (Journal Article)

Journal of the American Chemical Society, 140 (51), pp. 17872-17877, 2018, (cited By 0).

(Links | BibTeX)

France, S P; Aleku, G A; Sharma, M; Mangas-Sanchez, J; Howard, R M; Steflik, J; Kumar, R; Adams, R W; Slabu, I; Crook, R; Grogan, G; Wallace, T W; Turner, N J

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines (Journal Article)

Angewandte Chemie - International Edition, 56 (49), pp. 15589-15593, 2017.

(Links | BibTeX)

Slabu, I; Galman, J L; Lloyd, R C; Turner, N J

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts (Journal Article)

ACS Catalysis, 7 (12), pp. 8263-8284, 2017.

(Links | BibTeX)

Weise, N J; Ahmed, S T; Parmeggiani, F; Galman, J L; Dunstan, M S; Charnock, S J; Leys, D; Turner, N J

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes (Journal Article)

Scientific Reports, 7 (1), 2017.

(Links | BibTeX)

Fisk, H; Xu, Y; Westley, C; Turner, N J; Micklefield, J; Goodacre, R

From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy (Journal Article)

Analytical Chemistry, 89 (22), pp. 12527-12532, 2017.

(Links | BibTeX)

Wood, A J L; Weise, N J; Frampton, J D; Dunstan, M S; Hollas, M A; Derrington, S R; Lloyd, R C; Quaglia, D; Parmeggiani, F; Leys, D; Turner, N J; Flitsch, S L

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides (Journal Article)

Angewandte Chemie - International Edition, 56 (46), pp. 14498-14501, 2017.

(Links | BibTeX)

Hartley, C J; French, N G; Scoble, J A; Williams, C C; Churches, Q I; Frazer, A R; Taylor, M C; Coia, G; Simpson, G; Turner, N J; Scott, C

Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis (Journal Article)

PLoS ONE, 12 (11), 2017.

(Links | BibTeX)

Thompson, M P; Turner, N J

Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase (Journal Article)

ChemCatChem, 9 (20), pp. 3833-3836, 2017.

(Links | BibTeX)

Aleku, G A; France, S P; Man, H; Mangas-Sanchez, J; Montgomery, S L; Sharma, M; Leipold, F; Hussain, S; Grogan, G; Turner, N J

A reductive aminase from Aspergillus oryzae (Journal Article)

Nature Chemistry, 9 (10), pp. 961-969, 2017.

(Links | BibTeX)

Chapman, M R; Kwan, M H T; King, G; Jolley, K E; Hussain, M; Hussain, S; Salama, I E; Nino, González C; Thompson, L A; Bayana, M E; Clayton, A D; Nguyen, B N; Turner, N J; Kapur, N; Blacker, A J

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times (Journal Article)

Organic Process Research and Development, 21 (9), pp. 1294-1301, 2017.

(Links | BibTeX)

Tavanti, M; Parmeggiani, F; Castellanos, J R G; Mattevi, A; Turner, N J

One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone (Journal Article)

ChemCatChem, 9 (17), pp. 3338-3348, 2017.

(Links | BibTeX)

Ahmed, S T; Weise, N J; Parmeggiani, F; Turner, N J

Applications of phenylalanine ammonia lyases in synthesis: Access to enantiopure arylalanines from laboratory scale to industrial production (Journal Article)

Chimica Oggi/Chemistry Today, 35 (5), pp. 30-33, 2017.

(Links | BibTeX)

Gahloth, D; Dunstan, M S; Quaglia, D; Klumbys, E; Lockhart-Cairns, M P; Hill, A M; Derrington, S R; Scrutton, N S; Turner, N J; Leys, D

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis (Journal Article)

Nature Chemical Biology, 13 (9), pp. 975-981, 2017.

(Links | BibTeX)

Zajkoska, P; Cárdenas-Fernández, M; Lye, G J; Rosenberg, M; Turner, N J; Rebroš, M

Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase (Journal Article)

Journal of Chemical Technology and Biotechnology, 92 (7), pp. 1558-1565, 2017.

(Links | BibTeX)

Barley, M H; Turner, N J; Goodacre, R

Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes (Journal Article)

ChemBioChem, 18 (12), pp. 1087-1097, 2017.

(Links | BibTeX)

Sharma, M; Mangas-Sanchez, J; Turner, N J; Grogan, G

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application (Journal Article)

Advanced Synthesis and Catalysis, 359 (12), pp. 2011-2025, 2017.

(Links | BibTeX)

Weise, N J; Ahmed, S T; Parmeggiani, F; Turner, N J

Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts (Journal Article)

Advanced Synthesis and Catalysis, 359 (9), pp. 1570-1576, 2017.

(Links | BibTeX)

Hepworth, L J; France, S P; Hussain, S; Both, P; Turner, N J; Flitsch, S L

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines (Journal Article)

ACS Catalysis, 7 (4), pp. 2920-2925, 2017.

(Links | BibTeX)

Mangas-Sanchez, J; France, S P; Montgomery, S L; Aleku, G A; Man, H; Sharma, M; Ramsden, J I; Grogan, G; Turner, N J

Imine reductases (IREDs) (Journal Article)

Current Opinion in Chemical Biology, 37 , pp. 19-25, 2017.

(Links | BibTeX)

Klenk, J M; Nebel, B A; Porter, J L; Kulig, J K; Hussain, S A; Richter, S M; Tavanti, M; Turner, N J; Hayes, M A; Hauer, B; Flitsch, S L

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac (Journal Article)

Biotechnology Journal, 12 (3), 2017.

(Links | BibTeX)

Westley, C; Xu, Y; Thilaganathan, B; Carnell, A J; Turner, N J; Goodacre, R

Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method (Journal Article)

Analytical Chemistry, 89 (4), pp. 2472-2477, 2017.

(Links | BibTeX)

Hugentobler, K G; Rasparini, M; Thompson, L A; Jolley, K E; Blacker, A J; Turner, N J

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor (Journal Article)

Organic Process Research and Development, 21 (2), pp. 195-199, 2017.

(Links | BibTeX)

Scalacci, N; Black, G W; Mattedi, G; Brown, N L; Turner, N J; Castagnolo, D

Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles (Journal Article)

ACS Catalysis, 7 (2), pp. 1295-1300, 2017.

(Links | BibTeX)

Yan, C; Parmeggiani, F; Jones, E A; Claude, E; Hussain, S A; Turner, N J; Flitsch, S L; Barran, P E

Real-time screening of biocatalysts in live bacterial colonies (Journal Article)

Journal of the American Chemical Society, 139 (4), pp. 1408-1411, 2017.

(Links | BibTeX)

France, S P; Hepworth, L J; Turner, N J; Flitsch, S L

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways (Journal Article)

ACS Catalysis, 7 (1), pp. 710-724, 2017.

(Links | BibTeX)

Hönig, M; Sondermann, P; Turner, N J; Carreira, E M

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis (Journal Article)

Angewandte Chemie - International Edition, 56 (31), pp. 8942-8973, 2017.

(Links | BibTeX)

Tavanti, M; Mangas-Sanchez, J; Montgomery, S L; Thompson, M P; Turner, N J

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes (Journal Article)

Organic and Biomolecular Chemistry, 15 (46), pp. 9790-9793, 2017.

(Links | BibTeX)

Galman, J L; Slabu, I; Weise, N J; Iglesias, C; Parmeggiani, F; Lloyd, R C; Turner, N J

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases (Journal Article)

Green Chemistry, 19 (2), pp. 361-366, 2017.

(Links | BibTeX)

Weissenborn, M J; Debecker, D P; Golten, S; Linclau, B; Turner, N J; Flitsch, S L

Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors (Journal Article)

Protein and Peptide Letters, 24 (8), pp. 742-746, 2017.

(Links | BibTeX)

Aslan, A S; Valjakka, J; Ruupunen, J; Yildirim, D; Turner, N J; Turunen, O; Binay, B

Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3 -) to formate (Journal Article)

Protein engineering, design & selection : PEDS, 30 (1), pp. 47-55, 2017.

(Links | BibTeX)

Montgomery, S L; Mangas-Sanchez, J; Thompson, M P; Aleku, G A; Dominguez, B; Turner, N J

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing (Journal Article)

Angewandte Chemie - International Edition, 56 (35), pp. 10491-10494, 2017.

(Links | BibTeX)

Westley, C; Fisk, H; Xu, Y; Hollywood, K A; Carnell, A J; Micklefield, J; Turner, N J; Goodacre, R

Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy (Journal Article)

Chemistry - A European Journal, 23 (29), pp. 6983-6987, 2017.

(Links | BibTeX)

McKenna, S M; Mines, P; Law, P; Kovacs-Schreiner, K; Birmingham, W R; Turner, N J; Leimkühler, S; Carnell, A J

The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC) (Journal Article)

Green Chemistry, 19 (19), pp. 4660-4665, 2017.

(Links | BibTeX)

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination (Journal Article)

Organic Letters, 18 (21), pp. 5468-5471, 2016.

(Links | BibTeX)

Oosterwijk, Van N; Willies, S; Hekelaar, J; Scheltinga, Terwisscha Van A C; Turner, N J; Dijkstra, B W

Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases (Journal Article)

Biochemistry, 55 (31), pp. 4422-4431, 2016.

(Links | BibTeX)

Turner, N J

Sustainable catalysis (Journal Article)

Beilstein Journal of Organic Chemistry, 12 , pp. 1778-1779, 2016.

(Links | BibTeX)

Markošová, K; Dolejš, I; Stloukal, R; Rios-Solis, L; Rosenberg, M; Micheletti, M; Lye, G J; Turner, N J; Rebroš, M

Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels (Journal Article)

Journal of Molecular Catalysis B: Enzymatic, 129 , pp. 69-74, 2016.

(Links | BibTeX)

Carbonell, P; Currin, A; Dunstan, M; Fellows, D; Jervis, A; Rattray, N J W; Robinson, C J; Swainston, N; Vinaixa, M; Williams, A; Yan, C; Barran, P; Breitling, R; Chen, G G -Q; Faulon, J -L; Goble, C; Goodacre, R; Kell, D B; Feuvre, R L; Micklefield, J; Scrutton, N S; Shapira, P; Takano, E; Turner, N J

SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals (Journal Article)

Biochemical Society Transactions, 44 (3), pp. 675-677, 2016.

(Links | BibTeX)

Westley, C; Xu, Y; Carnell, A J; Turner, N J; Goodacre, R

Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts (Journal Article)

Analytical Chemistry, 88 (11), pp. 5898-5903, 2016.

(Links | BibTeX)

France, S P; Hussain, S; Hill, A M; Hepworth, L J; Howard, R M; Mulholland, K R; Flitsch, S L; Turner, N J

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts (Journal Article)

ACS Catalysis, 6 (6), pp. 3753-3759, 2016.

(Links | BibTeX)

Aleku, G A; Man, H; France, S P; Leipold, F; Hussain, S; Toca-Gonzalez, L; Marchington, R; Hart, S; Turkenburg, J P; Grogan, G; Turner, N J

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis (Journal Article)

ACS Catalysis, 6 (6), pp. 3880-3889, 2016.

(Links | BibTeX)

Aslan, A S; Birmingham, W R; Karagüler, N G; Turner, N J; Binay, B

Semi-Rational Design of Geobacillus stearothermophilus L-Lactate Dehydrogenase to Access Various Chiral α-Hydroxy Acids (Journal Article)

Applied Biochemistry and Biotechnology, 179 (3), pp. 474-484, 2016.

(Links | BibTeX)

Yan, C; Schmidberger, J W; Parmeggiani, F; Hussain, S A; Turner, N J; Flitsch, S L; Barran, P

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry (Journal Article)

Analyst, 141 (8), pp. 2351-2355, 2016.

(Links | BibTeX)

Slabu, I; Galman, J L; Weise, N J; Lloyd, R C; Turner, N J

Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines (Journal Article)

ChemCatChem, 8 (6), pp. 1038-1042, 2016.

(Links | BibTeX)

Wells, A S; Wong, J W; Michels, P C; Entwistle, D A; Fandrick, K; Finch, G L; Goswami, A; Lee, H; Mix, S; Moody, T S; Pang, L; Sato, R K; Turner, N J; Watson, T J

Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form (Journal Article)

Organic Process Research and Development, 20 (3), pp. 594-601, 2016.

(Links | BibTeX)

Eichler, A; Gricman, Ł; Herter, S; Kelly, P P; Turner, N J; Pleiss, J; Flitsch, S L

Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling (Journal Article)

ChemBioChem, 17 (5), pp. 426-432, 2016.

(Links | BibTeX)

Willies, S C; Galman, J L; Slabu, I; Turner, N J

A stereospecific solid-phase screening assay for colonies expressing both (R)-and (S)-selective Ω-Aminotransferases (Journal Article)

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 374 (2061), 2016.

(Links | BibTeX)

Grogan, G; Turner, N J

InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines (Journal Article)

Chemistry - A European Journal, 22 (6), pp. 1900-1907, 2016.

(Links | BibTeX)

Both, P; Busch, H; Kelly, P P; Mutti, F G; Turner, N J; Flitsch, S L

Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions (Journal Article)

Angewandte Chemie - International Edition, 55 (4), pp. 1511-1513, 2016.

(Links | BibTeX)

Heath, R S; Pontini, M; Hussain, S; Turner, N J

Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles (Journal Article)

ChemCatChem, 8 (1), pp. 117-120, 2016.

(Links | BibTeX)

Fisk, H; Westley, C; Turner, N J; Goodacre, R

Achieving optimal SERS through enhanced experimental design (Journal Article)

Journal of Raman Spectroscopy, 47 (1), pp. 59-66, 2016.

(Links | BibTeX)

Roselló, J M; Staniland, S; Turner, N J; Clayden, J

Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation (Journal Article)

Tetrahedron, 72 (34), pp. 5172-5177, 2016.

(Links | BibTeX)

Parmeggiani, F; Ahmed, S T; Weise, N J; Turner, N J

Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes (Journal Article)

Tetrahedron, 72 (46), pp. 7256-7262, 2016.

(Links | BibTeX)

Hugentobler, K G; Sharif, H; Rasparini, M; Heath, R S; Turner, N J

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor (Journal Article)

Organic and Biomolecular Chemistry, 14 (34), pp. 8064-8067, 2016.

(Links | BibTeX)

Rowles, I; Groenendaal, B; Binay, B; Malone, K J; Willies, S C; Turner, N J

Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids (Journal Article)

Tetrahedron, 72 (46), pp. 7343-7347, 2016.

(Links | BibTeX)

Weise, N J; Ahmed, S T; Parmeggiani, F; Siirola, E; Pushpanath, A; Schell, U; Turner, N J

Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source (Journal Article)

Catalysis Science and Technology, 6 (12), pp. 4086-4089, 2016.

(Links | BibTeX)

Parmeggiani, F; Ahmed, S T; Thompson, M P; Weise, N J; Galman, J L; Gahloth, D; Dunstan, M S; Leys, D; Turner, N J

Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase (Journal Article)

Advanced Synthesis and Catalysis, 358 (20), pp. 3298-3306, 2016.

(Links | BibTeX)

Weissenborn, M J; Notonier, S; Lang, S -L; Otte, K B; Herter, S; Turner, N J; Flitsch, S L; Hauer, B

Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s (Journal Article)

Chemical Communications, 52 (36), pp. 6158-6161, 2016.

(Links | BibTeX)

Staniland, S; Adams, R W; McDouall, J J W; Maffucci, I; Contini, A; Grainger, D M; Turner, N J; Clayden, J

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts (Journal Article)

Angewandte Chemie - International Edition, 55 (36), pp. 10755-10759, 2016.

(Links | BibTeX)

de Graaff, C; Oppelaar, B; Péruch, O; Velde, Vande C M L; Bechi, B; Turner, N J; Ruijter, E; Orru, R V A

Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer (Journal Article)

Advanced Synthesis and Catalysis, 358 (10), pp. 1555-1560, 2016.

(Links | BibTeX)

Özgün, G; Karagüler, N G; Turunen, O; Turner, N J; Binay, B

Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum (Journal Article)

Journal of Molecular Catalysis B: Enzymatic, 122 , pp. 212-217, 2015.

(Links | BibTeX)

Pedersen, Toftgaard A; Birmingham, W R; Rehn, G; Charnock, S J; Turner, N J; Woodley, J M

Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols (Journal Article)

Organic Process Research and Development, 19 (11), pp. 1580-1589, 2015.

(Links | BibTeX)

Graaff, De C; Bensch, L; Boersma, S J; Cioc, R C; Lint, Van M J; Janssen, E; Turner, N J; Orru, R V A; Ruijter, E

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction (Journal Article)

Angewandte Chemie - International Edition, 54 (47), pp. 14133-14136, 2015.

(Links | BibTeX)

Weise, N J; Parmeggiani, F; Ahmed, S T; Turner, N J

The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids (Journal Article)

Journal of the American Chemical Society, 137 (40), pp. 12977-12983, 2015.

(Links | BibTeX)

Mutti, F G; Knaus, T; Scrutton, N S; Breuer, M; Turner, N J

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades (Journal Article)

Science, 349 (6255), pp. 1525-1529, 2015.

(Links | BibTeX)

Kelly, P P; Eichler, A; Herter, S; Kranz, D C; Turner, N J; Flitsch, S L

Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions (Journal Article)

Beilstein Journal of Organic Chemistry, 11 , pp. 1713-1720, 2015.

(Links | BibTeX)

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation (Journal Article)

ACS Catalysis, 5 (9), pp. 5410-5413, 2015.

(Links | BibTeX)

Herter, S; McKenna, S M; Frazer, A R; Leimkühler, S; Carnell, A J; Turner, N J

Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis (Journal Article)

ChemCatChem, 7 (15), pp. 2313-2317, 2015.

(Links | BibTeX)

McKenna, S M; Leimkühler, S; Herter, S; Turner, N J; Carnell, A J

Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem (Journal Article)

Green Chemistry, 17 (6), pp. 3271-3275, 2015.

(Links | BibTeX)

Man, H; Wells, E; Hussain, S; F., Dr. Leipold; Hart, S; J.P., Dr. Turkenburg; N.J., Prof. Dr. Turner; Grogan, G

Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline (Journal Article)

ChemBioChem, 16 (7), pp. 1052-1059, 2015.

(Links | BibTeX)

Faber, K; Fessner, W -D; Turner, N J

Engineering biocatalysts for synthesis including cascade processes (Journal Article)

Advanced Synthesis and Catalysis, 357 (8), pp. 1565-1566, 2015.

(Links | BibTeX)

Parmeggiani, F; Lovelock, S L; Weise, N J; Ahmed, S T; Turner, N J

Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process (Journal Article)

Angewandte Chemie - International Edition, 54 (15), pp. 4608-4611, 2015.

(Links | BibTeX)

Köhler, V; Turner, N J

Artificial concurrent catalytic processes involving enzymes (Journal Article)

Chemical Communications, 51 (3), pp. 450-464, 2015.

(Links | BibTeX)

Knaus, T; Mutti, F G; Humphreys, L D; Turner, N J; Scrutton, N S

Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes (Journal Article)

Organic and Biomolecular Chemistry, 13 (1), pp. 223-233, 2015.

(Links | BibTeX)

Hussain, S; Leipold, F; Man, H; Wells, E; France, S P; Mulholland, K R; Grogan, G; Turner, N J

An (R)-imine reductase biocatalyst for the asymmetric reduction of cyclic imines (Journal Article)

ChemCatChem, 7 (4), pp. 579-583, 2015.

(Links | BibTeX)

Lovelock, S L; Turner, N J

Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity (Journal Article)

Bioorganic and Medicinal Chemistry, 22 (20), pp. 5555-5557, 2014.

(Links | BibTeX)

Bechi, B; Herter, S; McKenna, S; Riley, C; Leimkühler, S; Turner, N J; Carnell, A J

Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis (Journal Article)

Green Chemistry, 16 (10), pp. 4524-4529, 2014.

(Links | BibTeX)

Staniland, S; Yuan, B; Giménez-Agullõ, N; Marcelli, T; Willies, S C; Grainger, D M; Turner, N J; Clayden, J

Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers (Journal Article)

Chemistry - A European Journal, 20 (41), pp. 13084-13088, 2014.

(Links | BibTeX)

Scheller, P N; Fademrecht, S; Hofelzer, S; Pleiss, J; Leipold, F; Turner, N J; Nestl, B M; Hauer, B

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases (Journal Article)

ChemBioChem, 15 (15), pp. 2201-2204, 2014.

(Links | BibTeX)

Schrittwieser, J H; Groenendaal, B; Willies, S C; Ghislieri, D; Rowles, I; Resch, V; Sattler, J H; Fischereder, E -M; Grischek, B; Lienhart, W -D; Turner, N J; Kroutil, W

Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants (Journal Article)

Catalysis Science and Technology, 4 (10), pp. 3657-3664, 2014.

(Links | BibTeX)

Green, A P; Turner, N J; O'Reilly, E

Chiral amine synthesis using ω-transaminases: An amine donor that displaces equilibria and enables high-throughput screening (Journal Article)

Angewandte Chemie - International Edition, 53 (40), pp. 10714-10717, 2014.

(Links | BibTeX)

Lovelock, S L; Lloyd, R C; Turner, N J

Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway (Journal Article)

Angewandte Chemie - International Edition, 53 (18), pp. 4652-4656, 2014.

(Links | BibTeX)

Schrittwieser, J H; Groenendaal, B; Resch, V; Ghislieri, D; Wallner, S; Fischereder, E -M; Fuchs, E; Grischek, B; Sattler, J H; MacHeroux, P; Turner, N J; Kroutil, W

Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion (Journal Article)

Angewandte Chemie - International Edition, 53 (14), pp. 3731-3734, 2014.

(Links | BibTeX)

Ghislieri, D; Turner, N J

Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines (Journal Article)

Topics in Catalysis, 57 (5), pp. 284-300, 2014.

(Links | BibTeX)

Turner, N J; Whittall, J; Ward, T R

Foreword (Journal Article)

Topics in Catalysis, 57 (5), pp. 283, 2014.

(Links | BibTeX)

O'Reilly, E; Iglesias, C; Ghislieri, D; Hopwood, J; Galman, J L; Lloyd, R C; Turner, N J

A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines (Journal Article)

Angewandte Chemie - International Edition, 53 (9), pp. 2447-2450, 2014.

(Links | BibTeX)

Turner, N J; Wells, A

The enzyme spring: Biocatalysis at its best (Journal Article)

ChemCatChem, 6 (4), pp. 900-901, 2014.

(Links | BibTeX)

Heath, R S; Pontini, M; Bechi, B; Turner, N J

Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity (Journal Article)

ChemCatChem, 6 (4), pp. 996-1002, 2014.

(Links | BibTeX)

O'Reilly, E; Iglesias, C; Turner, N J

Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines (Journal Article)

ChemCatChem, 6 (4), pp. 992-995, 2014.

(Links | BibTeX)

Heap, L; Green, A; Brown, D; Dongen, Van B; Turner, N

Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification (Journal Article)

Catalysis Science and Technology, 4 (8), pp. 2251-2259, 2014.

(Links | BibTeX)

Zajkoska, P; Rosenberg, M; Heath, R; Malone, K J; Stloukal, R; Turner, N J; Rebroš, M

Immobilised whole-cell recombinant monoamine oxidase biocatalysis (Journal Article)

Applied Microbiology and Biotechnology, 99 (3), pp. 1229-1236, 2014.

(Links | BibTeX)

Ghislieri, D; Houghton, D; Green, A P; Willies, S C; Turner, N J

Monoamine oxidase (MAO-N) catalyzed deracemization of tetrahydro-β- carbolines: Substrate dependent switch in enantioselectivity (Journal Article)

ACS Catalysis, 3 (12), pp. 2869-2872, 2013.

(Links | BibTeX)

Leipold, F; Hussain, S; Ghislieri, D; Turner, N J

Asymmetric reduction of cyclic imines catalyzed by a whole-cell biocatalyst containing an (S)-imine reductase (Journal Article)

ChemCatChem, 5 (12), pp. 3505-3508, 2013.

(Links | BibTeX)

Ghislieri, D; Green, A P; Pontini, M; Willies, S C; Rowles, I; Frank, A; Grogan, G; Turner, N J

Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products (Journal Article)

Journal of the American Chemical Society, 135 (29), pp. 10863-10869, 2013.

(Links | BibTeX)

Rodríguez-Mata, M; Frank, A; Wells, E; Leipold, F; Turner, N J; Hart, S; Turkenburg, J P; Grogan, G

Structure and activity of NADPH-dependent reductase Q1EQE0 from streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate (Journal Article)

ChemBioChem, 14 (11), pp. 1372-1379, 2013.

(Links | BibTeX)

O'Reilly, E; Corbett, M; Hussain, S; Kelly, P P; Richardson, D; Flitsch, S L; Turner, N J

Substrate promiscuity of cytochrome P450 RhF (Journal Article)

Catalysis Science and Technology, 3 (6), pp. 1490-1492, 2013.

(Links | BibTeX)

Turner, N J; Truppo, M D

Biocatalysis enters a new era (Journal Article)

Current Opinion in Chemical Biology, 17 (2), pp. 212-214, 2013.

(Links | BibTeX)

Köhler, V; Wilson, Y M; Dürrenberger, M; Ghislieri, D; Churakova, E; Quinto, T; Knörr, L; Häussinger, D; Hollmann, F; Turner, N J; Ward, T R

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes (Journal Article)

Nature Chemistry, 5 (2), pp. 93-99, 2013.

(Links | BibTeX)

Akhtara, Kalim M; Turner, N J; Jones, P R

Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities (Journal Article)

Proceedings of the National Academy of Sciences of the United States of America, 110 (1), pp. 87-92, 2013.

(Links | BibTeX)

Turner, N J; O'reilly, E

Biocatalytic retrosynthesis (Journal Article)

Nature Chemical Biology, 9 (5), pp. 285-288, 2013.

(Links | BibTeX)

Willies, S C; White, J L; Turner, N J

Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine (Journal Article)

Tetrahedron, 68 (37), pp. 7564-7567, 2012.

(Links | BibTeX)

Rowles, I; Malone, K J; Etchells, L L; Willies, S C; Turner, N J

Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea (Journal Article)

ChemCatChem, 4 (9), pp. 1259-1261, 2012.

(Links | BibTeX)

Turner, N J

Biocatalysis (Journal Article)

Catalysis Science and Technology, 2 (8), pp. 1523, 2012.

(Links | BibTeX)

March-Cortijos, A; Snape, T J; Turner, N J

Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure (Journal Article)

Synlett, 23 (10), pp. 1511-1515, 2012.

(Links | BibTeX)

O'Reilly, E; Aitken, S J; Grogan, G; Kelly, P P; Turner, N J; Flitsch, S L

Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous (Journal Article)

Beilstein Journal of Organic Chemistry, 8 , pp. 496-500, 2012.