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2019

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Thompson, M P; Derrington, S R; Heath, R S; Porter, J L; Mangas-Sanchez, J; Devine, P N; Truppo, M D; Turner, N J

A generic platform for the immobilisation of engineered biocatalysts (Journal Article)

Tetrahedron, 75 (3), pp. 327-334, 2019.

(Links | BibTeX)

A generic platform for the immobilisation of engineered biocatalysts

Heath, R S; Birmingham, W R; Thompson, M P; Taglieber, A; Daviet, L; Turner, N J

An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols (Journal Article)

ChemBioChem, 20 (2), pp. 276-281, 2019.

(Links | BibTeX)

An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols

Thompson, M P; Peñafiel, I; Cosgrove, S C; Turner, N J

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals (Journal Article)

Organic Process Research and Development, 23 (1), pp. 9-18, 2019.

(Links | BibTeX)

Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals

Ramsden, J I; Heath, R S; Derrington, S R; Montgomery, S L; Mangas-Sanchez, J; Mulholland, K R; Turner, N J

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades (Journal Article)

Journal of the American Chemical Society, 141 (3), pp. 1201-1206, 2019.

(Links | BibTeX)

Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades

Megarity, C F; Siritanaratkul, B; Heath, R S; Wan, L; Morello, G; FitzPatrick, S R; Booth, R L; Sills, A J; Robertson, A W; Warner, J H; Turner, N J; Armstrong, F A

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores (Journal Article)

Angewandte Chemie - International Edition, 58 (15), pp. 4948-4952, 2019.

(Links | BibTeX)

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Manning, J; Tavanti, M; Porter, J L; Kress, N; Visser, De S P; Turner, N J; Flitsch, S L

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S)-δ-Decalactone (Journal Article)

Angewandte Chemie - International Edition, 58 (17), pp. 5668-5671, 2019.

(Links | BibTeX)

Regio- and Enantio-selective Chemo-enzymatic C−H-Lactonization of Decanoic Acid to (S)-δ-Decalactone

Parmeggiani, F; Casamajo, Rué A; Walton, C J W; Galman, J L; Turner, N J; Chica, R A

One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase (Journal Article)

ACS Catalysis, 9 (4), pp. 3482-3486, 2019.

(Links | BibTeX)

One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase

Faber, K; Fessner, W -D; Turner, N J

Biocatalysis: Ready to Master Increasing Complexity (Journal Article)

Advanced Synthesis and Catalysis, 361 (11), pp. 2373-2376, 2019.

(Links | BibTeX)

Bornadel, A; Bisagni, S; Pushpanath, A; Montgomery, S L; Turner, N J; Dominguez, B

Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study (Journal Article)

Organic Process Research and Development, 23 (6), pp. 1262-1268, 2019.

(Links | BibTeX)

Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study

Currin, A; Kwok, J; Sadler, J C; Bell, E L; Swainston, N; Ababi, M; Day, P; Turner, N J; Kell, D B

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries (Journal Article)

ACS Synthetic Biology, 8 (6), pp. 1371-1378, 2019.

(Links | BibTeX)

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

Kimber, Richard L; Parmeggiani, Fabio; Joshi, Nimisha; Rakowski, Alexander M; Haigh, Sarah J; Turner, Nicholas J; Lloyd, Jonathan R

Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles (Journal Article)

Green Chem., 21 (15), pp. 4020-4024, 2019.

(Abstract | Links | BibTeX)

Synthesis of copper catalysts for click chemistry from distillery wastewater using magnetically recoverable bionanoparticles

Parmeggiani, Fabio; Casamajo, Arnau Rué; Colombo, Danilo; Ghezzi, Maria Chiara; Galman, James Louis; Chica, Roberto A; Brenna, Elisabetta; Turner, Nicholas J

Biocatalytic retrosynthesis approaches to D-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin (Journal Article)

Green Chem., 21 (16), pp. 4368-4379, 2019.

(Links | BibTeX)

Biocatalytic retrosynthesis approaches to D-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin

Mourelle-Insua, Ángela; Méndez-Sánchez, Daniel; Galman, James L; Slabu, Iustina; Turner, Nicholas J; Gotor-Fernández, Vicente; Lavandera, Iván

Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions (Journal Article)

Catal. Sci. Technol., 9 (15), pp. 4083-4090, 2019.

(Links | BibTeX)

Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions

Derrington, S R; Turner, N J; France, S P

Carboxylic acid reductases (CARs): An industrial perspective (Journal Article)

Journal of Biotechnology, 304 , pp. 78-88, 2019.

(Links | BibTeX)

Carboxylic acid reductases (CARs): An industrial perspective

Wan, Lei; Heath, Rachel S; Siritanaratkul, Bhavin; Megarity, Clare F; Sills, Adam J; Thompson, Matthew P; Turner, Nicholas J; Armstrong, Fraser A

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores (Journal Article)

Green Chem., 21 (18), pp. 4958-4963, 2019.

(Links | BibTeX)

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

Schnepel, C; Turner, N J

Identifying an iodinase (Journal Article)

Nature Chemistry, 11 (12), pp. 1076-1078, 2019.

(Links | BibTeX)

Identifying an iodinase

Hartley, C J; Williams, C C; Scoble, J A; Churches, Q I; North, A; French, N G; Nebl, T; Coia, G; Warden, A C; Simpson, G; Frazer, A R; Jensen, C N; Turner, N J; Scott, C

Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis (Journal Article)

Nature Catalysis, 2 (11), pp. 1006-1015, 2019.

(Links | BibTeX)

Engineered enzymes that retain and regenerate their cofactors enable continuous-flow biocatalysis

Mattey, A P; Birmingham, W R; Both, P; Kress, N; Huang, K; Munster, Van J M; Bulmer, G S; Parmeggiani, F; Voglmeir, J; Martinez, J E R; Turner, N J; Flitsch, S L

Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant (Journal Article)

ACS Catalysis, 9 (9), pp. 8208-8212, 2019.

(Links | BibTeX)

Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant

2018

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Odachowski, M; Greaney, M F; Turner, N J

Concurrent Biocatalytic Oxidation and C-C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines (Journal Article)

ACS Catalysis, 8 (11), pp. 10032-10035, 2018.

(Links | BibTeX)

Concurrent Biocatalytic Oxidation and C-C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines

Costa, B Z; Galman, J L; Slabu, I; France, S P; Marsaioli, A J; Turner, N J

Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts (Journal Article)

ChemCatChem, 10 (20), pp. 4733-4738, 2018.

(Links | BibTeX)

Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts

Toscani, A; Risi, C; Black, G W; Brown, N L; Shaaban, A; Turner, N J; Castagnolo, D

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines (Journal Article)

ACS Catalysis, 8 (9), pp. 8781-8787, 2018.

(Links | BibTeX)

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Turner, N J

Enzymes team up with light-activated catalysts (Journal Article)

Nature, 560 (7718), pp. 310-311, 2018.

(Links | BibTeX)

Enzymes team up with light-activated catalysts

Chapman, M R; Cosgrove, S C; Turner, N J; Kapur, N; Blacker, A J

Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen (Journal Article)

Angewandte Chemie - International Edition, 57 (33), pp. 10535-10539, 2018.

(Links | BibTeX)

Highly Productive Oxidative Biocatalysis in Continuous Flow by Enhancing the Aqueous Equilibrium Solubility of Oxygen

Tavanti, M; Porter, J L; Levy, C W; Castellanos, Gómez J R; Flitsch, S L; Turner, N J

The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s (Journal Article)

Biochemical and Biophysical Research Communications, 501 (4), pp. 846-850, 2018.

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The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s

Carbonell, P; Wong, J; Swainston, N; Takano, E; Turner, N J; Scrutton, N S; Kell, D B; Breitling, R; Faulon, J -L

Selenzyme: Enzyme selection tool for pathway design (Journal Article)

Bioinformatics, 34 (12), pp. 2153-2154, 2018.

(Links | BibTeX)

Cosgrove, S C; Hussain, S; Turner, N J; Marsden, S P

Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines (Journal Article)

ACS Catalysis, 8 (6), pp. 5570-5573, 2018.

(Links | BibTeX)

Synergistic Chemo/Biocatalytic Synthesis of Alkaloidal Tetrahydroquinolines

Porter, J L; Sabatini, S; Manning, J; Tavanti, M; Galman, J L; Turner, N J; Flitsch, S L

Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope (Journal Article)

Enzyme and Microbial Technology, 113 , pp. 1-8, 2018.

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Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope

Slabu, I; Galman, J L; Iglesias, C; Weise, N J; Lloyd, R C; Turner, N J

n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones (Journal Article)

Catalysis Today, 306 , pp. 96-101, 2018.

(Links | BibTeX)

n-Butylamine as an alternative amine donor for the stereoselective biocatalytic transamination of ketones

Birmingham, W R; Turner, N J

A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase (Journal Article)

ACS Catalysis, 8 (5), pp. 4025-4032, 2018.

(Links | BibTeX)

A Single Enzyme Oxidative “Cascade” via a Dual-Functional Galactose Oxidase

Çakar, M M; Mangas-Sanchez, J; Birmingham, W R; Turner, N J; Binay, B

Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii (Journal Article)

Preparative Biochemistry and Biotechnology, 48 (4), pp. 327-334, 2018.

(Links | BibTeX)

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Engineered ammonia lyases for the production of challenging electron-rich l -phenylalanines (Journal Article)

ACS Catalysis, 8 (4), pp. 3129-3132, 2018.

(Links | BibTeX)

Engineered ammonia lyases for the production of challenging electron-rich l -phenylalanines

Turner, N J; Kumar, R

Editorial overview: Biocatalysis and biotransformation: The golden age of biocatalysis (Journal Article)

Current Opinion in Chemical Biology, 43 , pp. A1-A3, 2018.

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Weise, N J; Parmeggiani, F; Ahmed, S T; Turner, N J

Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis (Journal Article)

Topics in Catalysis, 61 (3-4), pp. 288-295, 2018.

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Discovery and Investigation of Mutase-like Activity in a Phenylalanine Ammonia Lyase from Anabaena variabilis

Herter, S; Medina, F; Wagschal, S; Benhaïm, C; Leipold, F; Turner, N J

Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines (Journal Article)

Bioorganic and Medicinal Chemistry, 26 (7), pp. 1338-1346, 2018.

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Mapping the substrate scope of monoamine oxidase (MAO-N) as a synthetic tool for the enantioselective synthesis of chiral amines

Morrill, C; Jensen, C; Just-Baringo, X; Grogan, G; Turner, N J; Procter, D J

Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles (Journal Article)

Angewandte Chemie - International Edition, 57 (14), pp. 3692-3696, 2018.

(Links | BibTeX)

Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles

Kimber, R L; Lewis, E A; Parmeggiani, F; Smith, K; Bagshaw, H; Starborg, T; Joshi, N; Figueroa, A I; van der Laan, G; Cibin, G; Gianolio, D; Haigh, S J; Pattrick, R A D; Turner, N J; Lloyd, J R

Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry (Journal Article)

Small, 14 (10), 2018.

(Links | BibTeX)

Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry

Tavanti, M; Porter, J L; Sabatini, S; Turner, N J; Flitsch, S L

Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope (Journal Article)

ChemCatChem, 10 (5), pp. 1042-1051, 2018.

(Links | BibTeX)

Panel of New Thermostable CYP116B Self-Sufficient Cytochrome P450 Monooxygenases that Catalyze C−H Activation with a Diverse Substrate Scope

Porter, J L; Manning, J; Sabatini, S; Tavanti, M; Turner, N J; Flitsch, S L

Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids (Journal Article)

ChemBioChem, 19 (5), pp. 513-520, 2018.

(Links | BibTeX)

Characterisation of CYP102A25 from Bacillus marmarensis and CYP102A26 from Pontibacillus halophilus: P450 Homologues of BM3 with Preference towards Hydroxylation of Medium-Chain Fatty Acids

Barley, M H; Turner, N J; Goodacre, R

Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins (Journal Article)

Journal of Chemical Information and Modeling, 58 (2), pp. 234-243, 2018.

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Improved Descriptors for the Quantitative Structure-Activity Relationship Modeling of Peptides and Proteins

France, S P; Howard, R M; Steflik, J; Weise, N J; Mangas-Sanchez, J; Montgomery, S L; Crook, R; Kumar, R; Turner, N J

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination (Journal Article)

ChemCatChem, 10 (3), pp. 510-514, 2018.

(Links | BibTeX)

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

Aleku, G A; Mangas-Sanchez, J; Citoler, J; France, S P; Montgomery, S L; Heath, R S; Thompson, M P; Turner, N J

Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase (Journal Article)

ChemCatChem, 10 (3), pp. 515-519, 2018.

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Kinetic Resolution and Deracemization of Racemic Amines Using a Reductive Aminase

Walton, C J W; Parmeggiani, F; Barber, J E B; McCann, J L; Turner, N J; Chica, R A

Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades (Journal Article)

ChemCatChem, 10 (2), pp. 470-474, 2018.

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Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades

Hutchings, G J; Catlow, C R; Turner, N J

Providing sustainable catalytic solutions for a rapidly changing world (Journal Article)

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376 (2110), 2018.

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Aleku, G A; Nowicka, B; Turner, N J

Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones (Journal Article)

ChemCatChem, 10 (1), pp. 124-135, 2018.

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Biocatalytic Potential of Enzymes Involved in the Biosynthesis of Isoprenoid Quinones

Galman, J L; Slabu, I; Parmeggiani, F; Turner, N J

Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction (Journal Article)

Chemical Communications, 54 (80), pp. 11316-11319, 2018.

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Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction

Parmeggiani, F; Weise, N J; Ahmed, S T; Turner, N J

Synthetic and therapeutic applications of ammonia-lyases and aminomutases (Journal Article)

Chemical Reviews, 118 (1), pp. 73-118, 2018.

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Synthetic and therapeutic applications of ammonia-lyases and aminomutases

Klumbys, E; Zebec, Z; Weise, N J; Turner, N J; Scrutton, N S

Bio-derived production of cinnamyl alcohol: Via a three step biocatalytic cascade and metabolic engineering (Journal Article)

Green Chemistry, 20 (3), pp. 658-663, 2018.

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Bio-derived production of cinnamyl alcohol: Via a three step biocatalytic cascade and metabolic engineering

Markošová, K; Camattari, A; Rosenberg, M; Glieder, A; Turner, N J; Rebroš, M

Cloning and upscale production of monoamine oxidase N (MAO-N D5) by Pichia pastoris (Journal Article)

Biotechnology Letters, 40 (1), pp. 127-133, 2018.

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Sharma, M; Mangas-Sanchez, J; France, S P; Aleku, G A; Montgomery, S L; Ramsden, J I; Turner, N J; Grogan, G

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases (Journal Article)

ACS Catalysis, pp. 11534-11541, 2018.

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A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases

Cosgrove, S C; Brzezniak, A; France, S P; Ramsden, J I; Mangas-Sanchez, J; Montgomery, S L; Heath, R S; Turner, N J

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications (Journal Article)

Methods in Enzymology, 608 , pp. 131-149, 2018.

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Batista, V F; Galman, J L; Pinto, D C; Silva, A M S; Turner, N J

Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization (Journal Article)

ACS Catalysis, 8 (12), pp. 11889-11907, 2018.

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Monoamine Oxidase: Tunable Activity for Amine Resolution and Functionalization

Xu, J; Green, A P; Turner, N J

Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles (Journal Article)

Angewandte Chemie - International Edition, 57 (51), pp. 16760-16763, 2018.

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Chemo-Enzymatic Synthesis of Pyrazines and Pyrroles

Devine, P N; Howard, R M; Kumar, R; Thompson, M P; Truppo, M D; Turner, N J

Extending the application of biocatalysis to meet the challenges of drug development (Journal Article)

Nature Reviews Chemistry, 2 (12), pp. 409-421, 2018.

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Extending the application of biocatalysis to meet the challenges of drug development

Burke, A J; Marques, C S; Turner, N J; Hermann, G J

Active pharmaceutical ingredients in synthesis: Catalytic processes in research and development (Book)

2018.

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Active pharmaceutical ingredients in synthesis: Catalytic processes in research and development

Zawodny, W; Montgomery, S L; Marshall, J R; Finnigan, J D; Turner, N J; Clayden, J

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement (Journal Article)

Journal of the American Chemical Society, 140 (51), pp. 17872-17877, 2018, (cited By 0).

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Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

2017

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France, S P; Aleku, G A; Sharma, M; Mangas-Sanchez, J; Howard, R M; Steflik, J; Kumar, R; Adams, R W; Slabu, I; Crook, R; Grogan, G; Wallace, T W; Turner, N J

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines (Journal Article)

Angewandte Chemie - International Edition, 56 (49), pp. 15589-15593, 2017.

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Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

Slabu, I; Galman, J L; Lloyd, R C; Turner, N J

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts (Journal Article)

ACS Catalysis, 7 (12), pp. 8263-8284, 2017.

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Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

Weise, N J; Ahmed, S T; Parmeggiani, F; Galman, J L; Dunstan, M S; Charnock, S J; Leys, D; Turner, N J

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes (Journal Article)

Scientific Reports, 7 (1), 2017.

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Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

Fisk, H; Xu, Y; Westley, C; Turner, N J; Micklefield, J; Goodacre, R

From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy (Journal Article)

Analytical Chemistry, 89 (22), pp. 12527-12532, 2017.

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From Multistep Enzyme Monitoring to Whole-Cell Biotransformations: Development of Real-Time Ultraviolet Resonance Raman Spectroscopy

Wood, A J L; Weise, N J; Frampton, J D; Dunstan, M S; Hollas, M A; Derrington, S R; Lloyd, R C; Quaglia, D; Parmeggiani, F; Leys, D; Turner, N J; Flitsch, S L

Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides (Journal Article)

Angewandte Chemie - International Edition, 56 (46), pp. 14498-14501, 2017.

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Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides

Hartley, C J; French, N G; Scoble, J A; Williams, C C; Churches, Q I; Frazer, A R; Taylor, M C; Coia, G; Simpson, G; Turner, N J; Scott, C

Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis (Journal Article)

PLoS ONE, 12 (11), 2017.

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Sugar analog synthesis by in vitro biocatalytic cascade: A comparison of alternative enzyme complements for dihydroxyacetone phosphate production as a precursor to rare chiral sugar synthesis

Thompson, M P; Turner, N J

Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase (Journal Article)

ChemCatChem, 9 (20), pp. 3833-3836, 2017.

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Two-Enzyme Hydrogen-Borrowing Amination of Alcohols Enabled by a Cofactor-Switched Alcohol Dehydrogenase

Aleku, G A; France, S P; Man, H; Mangas-Sanchez, J; Montgomery, S L; Sharma, M; Leipold, F; Hussain, S; Grogan, G; Turner, N J

A reductive aminase from Aspergillus oryzae (Journal Article)

Nature Chemistry, 9 (10), pp. 961-969, 2017.

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A reductive aminase from Aspergillus oryzae

Chapman, M R; Kwan, M H T; King, G; Jolley, K E; Hussain, M; Hussain, S; Salama, I E; Nino, González C; Thompson, L A; Bayana, M E; Clayton, A D; Nguyen, B N; Turner, N J; Kapur, N; Blacker, A J

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times (Journal Article)

Organic Process Research and Development, 21 (9), pp. 1294-1301, 2017.

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Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

Tavanti, M; Parmeggiani, F; Castellanos, J R G; Mattevi, A; Turner, N J

One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone (Journal Article)

ChemCatChem, 9 (17), pp. 3338-3348, 2017.

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One-Pot Biocatalytic Double Oxidation of α-Isophorone for the Synthesis of Ketoisophorone

Ahmed, S T; Weise, N J; Parmeggiani, F; Turner, N J

Applications of phenylalanine ammonia lyases in synthesis: Access to enantiopure arylalanines from laboratory scale to industrial production (Journal Article)

Chimica Oggi/Chemistry Today, 35 (5), pp. 30-33, 2017.

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Gahloth, D; Dunstan, M S; Quaglia, D; Klumbys, E; Lockhart-Cairns, M P; Hill, A M; Derrington, S R; Scrutton, N S; Turner, N J; Leys, D

Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis (Journal Article)

Nature Chemical Biology, 13 (9), pp. 975-981, 2017.

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Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis

Zajkoska, P; Cárdenas-Fernández, M; Lye, G J; Rosenberg, M; Turner, N J; Rebroš, M

Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase (Journal Article)

Journal of Chemical Technology and Biotechnology, 92 (7), pp. 1558-1565, 2017.

(Links | BibTeX)

Barley, M H; Turner, N J; Goodacre, R

Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes (Journal Article)

ChemBioChem, 18 (12), pp. 1087-1097, 2017.

(Links | BibTeX)

Recommendations on the Implementation of Genetic Algorithms for the Directed Evolution of Enzymes for Industrial Purposes

Sharma, M; Mangas-Sanchez, J; Turner, N J; Grogan, G

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application (Journal Article)

Advanced Synthesis and Catalysis, 359 (12), pp. 2011-2025, 2017.

(Links | BibTeX)

NAD(P)H-Dependent Dehydrogenases for the Asymmetric Reductive Amination of Ketones: Structure, Mechanism, Evolution and Application

Weise, N J; Ahmed, S T; Parmeggiani, F; Turner, N J

Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts (Journal Article)

Advanced Synthesis and Catalysis, 359 (9), pp. 1570-1576, 2017.

(Links | BibTeX)

Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts

Hepworth, L J; France, S P; Hussain, S; Both, P; Turner, N J; Flitsch, S L

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines (Journal Article)

ACS Catalysis, 7 (4), pp. 2920-2925, 2017.

(Links | BibTeX)

Enzyme Cascades in Whole Cells for the Synthesis of Chiral Cyclic Amines

Mangas-Sanchez, J; France, S P; Montgomery, S L; Aleku, G A; Man, H; Sharma, M; Ramsden, J I; Grogan, G; Turner, N J

Imine reductases (IREDs) (Journal Article)

Current Opinion in Chemical Biology, 37 , pp. 19-25, 2017.

(Links | BibTeX)

Imine reductases (IREDs)

Klenk, J M; Nebel, B A; Porter, J L; Kulig, J K; Hussain, S A; Richter, S M; Tavanti, M; Turner, N J; Hayes, M A; Hauer, B; Flitsch, S L

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac (Journal Article)

Biotechnology Journal, 12 (3), 2017.

(Links | BibTeX)

The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac

Westley, C; Xu, Y; Thilaganathan, B; Carnell, A J; Turner, N J; Goodacre, R

Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method (Journal Article)

Analytical Chemistry, 89 (4), pp. 2472-2477, 2017.

(Links | BibTeX)

Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method

Hugentobler, K G; Rasparini, M; Thompson, L A; Jolley, K E; Blacker, A J; Turner, N J

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor (Journal Article)

Organic Process Research and Development, 21 (2), pp. 195-199, 2017.

(Links | BibTeX)

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Scalacci, N; Black, G W; Mattedi, G; Brown, N L; Turner, N J; Castagnolo, D

Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles (Journal Article)

ACS Catalysis, 7 (2), pp. 1295-1300, 2017.

(Links | BibTeX)

Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles

Yan, C; Parmeggiani, F; Jones, E A; Claude, E; Hussain, S A; Turner, N J; Flitsch, S L; Barran, P E

Real-time screening of biocatalysts in live bacterial colonies (Journal Article)

Journal of the American Chemical Society, 139 (4), pp. 1408-1411, 2017.

(Links | BibTeX)

Real-time screening of biocatalysts in live bacterial colonies

France, S P; Hepworth, L J; Turner, N J; Flitsch, S L

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways (Journal Article)

ACS Catalysis, 7 (1), pp. 710-724, 2017.

(Links | BibTeX)

Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways

Hönig, M; Sondermann, P; Turner, N J; Carreira, E M

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis (Journal Article)

Angewandte Chemie - International Edition, 56 (31), pp. 8942-8973, 2017.

(Links | BibTeX)

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis

Tavanti, M; Mangas-Sanchez, J; Montgomery, S L; Thompson, M P; Turner, N J

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes (Journal Article)

Organic and Biomolecular Chemistry, 15 (46), pp. 9790-9793, 2017.

(Links | BibTeX)

A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

Hutchings, G; Davidson, M; Catlow, R; Hardacre, C; Turner, N; Collier, P

Modern developments in catalysis (Book)

2017.

(Links | BibTeX)

Modern developments in catalysis

Galman, J L; Slabu, I; Weise, N J; Iglesias, C; Parmeggiani, F; Lloyd, R C; Turner, N J

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases (Journal Article)

Green Chemistry, 19 (2), pp. 361-366, 2017.

(Links | BibTeX)

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

Weissenborn, M J; Debecker, D P; Golten, S; Linclau, B; Turner, N J; Flitsch, S L

Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors (Journal Article)

Protein and Peptide Letters, 24 (8), pp. 742-746, 2017.

(Links | BibTeX)

Development of a solid phase array assay for the screening of galactose oxidase activity and for fast identification of inhibitors

Aslan, A S; Valjakka, J; Ruupunen, J; Yildirim, D; Turner, N J; Turunen, O; Binay, B

Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3 -) to formate (Journal Article)

Protein engineering, design & selection : PEDS, 30 (1), pp. 47-55, 2017.

(Links | BibTeX)

Chaetomium thermophilum formate dehydrogenase has high activity in the reduction of hydrogen carbonate (HCO3 -) to formate

Montgomery, S L; Mangas-Sanchez, J; Thompson, M P; Aleku, G A; Dominguez, B; Turner, N J

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing (Journal Article)

Angewandte Chemie - International Edition, 56 (35), pp. 10491-10494, 2017.

(Links | BibTeX)

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing

Westley, C; Fisk, H; Xu, Y; Hollywood, K A; Carnell, A J; Micklefield, J; Turner, N J; Goodacre, R

Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy (Journal Article)

Chemistry - A European Journal, 23 (29), pp. 6983-6987, 2017.

(Links | BibTeX)

Real-Time Monitoring of Enzyme-Catalysed Reactions using Deep UV Resonance Raman Spectroscopy

McKenna, S M; Mines, P; Law, P; Kovacs-Schreiner, K; Birmingham, W R; Turner, N J; Leimkühler, S; Carnell, A J

The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC) (Journal Article)

Green Chemistry, 19 (19), pp. 4660-4665, 2017.

(Links | BibTeX)

The continuous oxidation of HMF to FDCA and the immobilisation and stabilisation of periplasmic aldehyde oxidase (PaoABC)

2016

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Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination (Journal Article)

Organic Letters, 18 (21), pp. 5468-5471, 2016.

(Links | BibTeX)

Synthesis of Enantiomerically Pure Ring-Substituted l -Pyridylalanines by Biocatalytic Hydroamination

Oosterwijk, Van N; Willies, S; Hekelaar, J; Scheltinga, Terwisscha Van A C; Turner, N J; Dijkstra, B W

Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases (Journal Article)

Biochemistry, 55 (31), pp. 4422-4431, 2016.

(Links | BibTeX)

Structural Basis of the Substrate Range and Enantioselectivity of Two (S)-Selective ω-Transaminases

Turner, N J

Sustainable catalysis (Journal Article)

Beilstein Journal of Organic Chemistry, 12 , pp. 1778-1779, 2016.

(Links | BibTeX)

Markošová, K; Dolejš, I; Stloukal, R; Rios-Solis, L; Rosenberg, M; Micheletti, M; Lye, G J; Turner, N J; Rebroš, M

Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels (Journal Article)

Journal of Molecular Catalysis B: Enzymatic, 129 , pp. 69-74, 2016.

(Links | BibTeX)

Immobilisation and kinetics of monoamine oxidase (MAO-N-D5) enzyme in polyvinyl alcohol gels

Carbonell, P; Currin, A; Dunstan, M; Fellows, D; Jervis, A; Rattray, N J W; Robinson, C J; Swainston, N; Vinaixa, M; Williams, A; Yan, C; Barran, P; Breitling, R; Chen, G G -Q; Faulon, J -L; Goble, C; Goodacre, R; Kell, D B; Feuvre, R L; Micklefield, J; Scrutton, N S; Shapira, P; Takano, E; Turner, N J

SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals (Journal Article)

Biochemical Society Transactions, 44 (3), pp. 675-677, 2016.

(Links | BibTeX)

SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

Westley, C; Xu, Y; Carnell, A J; Turner, N J; Goodacre, R

Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts (Journal Article)

Analytical Chemistry, 88 (11), pp. 5898-5903, 2016.

(Links | BibTeX)

Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts

France, S P; Hussain, S; Hill, A M; Hepworth, L J; Howard, R M; Mulholland, K R; Flitsch, S L; Turner, N J

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts (Journal Article)

ACS Catalysis, 6 (6), pp. 3753-3759, 2016.

(Links | BibTeX)

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts

Aleku, G A; Man, H; France, S P; Leipold, F; Hussain, S; Toca-Gonzalez, L; Marchington, R; Hart, S; Turkenburg, J P; Grogan, G; Turner, N J

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis (Journal Article)

ACS Catalysis, 6 (6), pp. 3880-3889, 2016.

(Links | BibTeX)

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

Aslan, A S; Birmingham, W R; Karagüler, N G; Turner, N J; Binay, B

Semi-Rational Design of Geobacillus stearothermophilus L-Lactate Dehydrogenase to Access Various Chiral α-Hydroxy Acids (Journal Article)

Applied Biochemistry and Biotechnology, 179 (3), pp. 474-484, 2016.

(Links | BibTeX)

Yan, C; Schmidberger, J W; Parmeggiani, F; Hussain, S A; Turner, N J; Flitsch, S L; Barran, P

Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry (Journal Article)

Analyst, 141 (8), pp. 2351-2355, 2016.

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Rapid and sensitive monitoring of biocatalytic reactions using ion mobility mass spectrometry

Slabu, I; Galman, J L; Weise, N J; Lloyd, R C; Turner, N J

Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines (Journal Article)

ChemCatChem, 8 (6), pp. 1038-1042, 2016.

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Putrescine Transaminases for the Synthesis of Saturated Nitrogen Heterocycles from Polyamines

Wells, A S; Wong, J W; Michels, P C; Entwistle, D A; Fandrick, K; Finch, G L; Goswami, A; Lee, H; Mix, S; Moody, T S; Pang, L; Sato, R K; Turner, N J; Watson, T J

Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form (Journal Article)

Organic Process Research and Development, 20 (3), pp. 594-601, 2016.

(Links | BibTeX)

Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form

Eichler, A; Gricman, Ł; Herter, S; Kelly, P P; Turner, N J; Pleiss, J; Flitsch, S L

Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling (Journal Article)

ChemBioChem, 17 (5), pp. 426-432, 2016.

(Links | BibTeX)

Enantioselective Benzylic Hydroxylation Catalysed by P450 Monooxygenases: Characterisation of a P450cam Mutant Library and Molecular Modelling

Willies, S C; Galman, J L; Slabu, I; Turner, N J

A stereospecific solid-phase screening assay for colonies expressing both (R)-and (S)-selective Ω-Aminotransferases (Journal Article)

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 374 (2061), 2016.

(Links | BibTeX)

A stereospecific solid-phase screening assay for colonies expressing both (R)-and (S)-selective Ω-Aminotransferases

Grogan, G; Turner, N J

InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines (Journal Article)

Chemistry - A European Journal, 22 (6), pp. 1900-1907, 2016.

(Links | BibTeX)

InspIRED by Nature: NADPH-Dependent Imine Reductases (IREDs) as Catalysts for the Preparation of Chiral Amines

Both, P; Busch, H; Kelly, P P; Mutti, F G; Turner, N J; Flitsch, S L

Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions (Journal Article)

Angewandte Chemie - International Edition, 55 (4), pp. 1511-1513, 2016.

(Links | BibTeX)

Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions

Heath, R S; Pontini, M; Hussain, S; Turner, N J

Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles (Journal Article)

ChemCatChem, 8 (1), pp. 117-120, 2016.

(Links | BibTeX)

Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles

Fisk, H; Westley, C; Turner, N J; Goodacre, R

Achieving optimal SERS through enhanced experimental design (Journal Article)

Journal of Raman Spectroscopy, 47 (1), pp. 59-66, 2016.

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Achieving optimal SERS through enhanced experimental design

Roselló, J M; Staniland, S; Turner, N J; Clayden, J

Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation (Journal Article)

Tetrahedron, 72 (34), pp. 5172-5177, 2016.

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Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation

Parmeggiani, F; Ahmed, S T; Weise, N J; Turner, N J

Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes (Journal Article)

Tetrahedron, 72 (46), pp. 7256-7262, 2016.

(Links | BibTeX)

Telescopic one-pot condensation-hydroamination strategy for the synthesis of optically pure L-phenylalanines from benzaldehydes

Hugentobler, K G; Sharif, H; Rasparini, M; Heath, R S; Turner, N J

Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor (Journal Article)

Organic and Biomolecular Chemistry, 14 (34), pp. 8064-8067, 2016.

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Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor

Rowles, I; Groenendaal, B; Binay, B; Malone, K J; Willies, S C; Turner, N J

Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids (Journal Article)

Tetrahedron, 72 (46), pp. 7343-7347, 2016.

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Engineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids

Weise, N J; Ahmed, S T; Parmeggiani, F; Siirola, E; Pushpanath, A; Schell, U; Turner, N J

Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source (Journal Article)

Catalysis Science and Technology, 6 (12), pp. 4086-4089, 2016.

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Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source

Parmeggiani, F; Ahmed, S T; Thompson, M P; Weise, N J; Galman, J L; Gahloth, D; Dunstan, M S; Leys, D; Turner, N J

Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase (Journal Article)

Advanced Synthesis and Catalysis, 358 (20), pp. 3298-3306, 2016.

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Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase

Weissenborn, M J; Notonier, S; Lang, S -L; Otte, K B; Herter, S; Turner, N J; Flitsch, S L; Hauer, B

Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s (Journal Article)

Chemical Communications, 52 (36), pp. 6158-6161, 2016.

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Whole-cell microtiter plate screening assay for terminal hydroxylation of fatty acids by P450s

Staniland, S; Adams, R W; McDouall, J J W; Maffucci, I; Contini, A; Grainger, D M; Turner, N J; Clayden, J

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts (Journal Article)

Angewandte Chemie - International Edition, 55 (36), pp. 10755-10759, 2016.

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Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts

de Graaff, C; Oppelaar, B; Péruch, O; Velde, Vande C M L; Bechi, B; Turner, N J; Ruijter, E; Orru, R V A

Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer (Journal Article)

Advanced Synthesis and Catalysis, 358 (10), pp. 1555-1560, 2016.

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Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer

2015

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Özgün, G; Karagüler, N G; Turunen, O; Turner, N J; Binay, B

Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum (Journal Article)

Journal of Molecular Catalysis B: Enzymatic, 122 , pp. 212-217, 2015.

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Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum

Pedersen, Toftgaard A; Birmingham, W R; Rehn, G; Charnock, S J; Turner, N J; Woodley, J M

Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols (Journal Article)

Organic Process Research and Development, 19 (11), pp. 1580-1589, 2015.

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Process Requirements of Galactose Oxidase Catalyzed Oxidation of Alcohols

Graaff, De C; Bensch, L; Boersma, S J; Cioc, R C; Lint, Van M J; Janssen, E; Turner, N J; Orru, R V A; Ruijter, E

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction (Journal Article)

Angewandte Chemie - International Edition, 54 (47), pp. 14133-14136, 2015.

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Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

Weise, N J; Parmeggiani, F; Ahmed, S T; Turner, N J

The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids (Journal Article)

Journal of the American Chemical Society, 137 (40), pp. 12977-12983, 2015.

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The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids

Mutti, F G; Knaus, T; Scrutton, N S; Breuer, M; Turner, N J

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades (Journal Article)

Science, 349 (6255), pp. 1525-1529, 2015.

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Kelly, P P; Eichler, A; Herter, S; Kranz, D C; Turner, N J; Flitsch, S L

Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions (Journal Article)

Beilstein Journal of Organic Chemistry, 11 , pp. 1713-1720, 2015.

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Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions

Ahmed, S T; Parmeggiani, F; Weise, N J; Flitsch, S L; Turner, N J

Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation (Journal Article)

ACS Catalysis, 5 (9), pp. 5410-5413, 2015.

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Chemoenzymatic Synthesis of Optically Pure l- and d-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation

Herter, S; McKenna, S M; Frazer, A R; Leimkühler, S; Carnell, A J; Turner, N J

Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis (Journal Article)

ChemCatChem, 7 (15), pp. 2313-2317, 2015.

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Galactose Oxidase Variants for the Oxidation of Amino Alcohols in Enzyme Cascade Synthesis

McKenna, S M; Leimkühler, S; Herter, S; Turner, N J; Carnell, A J

Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem (Journal Article)

Green Chemistry, 17 (6), pp. 3271-3275, 2015.

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Enzyme cascade reactions: Synthesis of furandicarboxylic acid (FDCA) and carboxylic acids using oxidases in tandem

Man, H; Wells, E; Hussain, S; F., Dr. Leipold; Hart, S; J.P., Dr. Turkenburg; N.J., Prof. Dr. Turner; Grogan, G

Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline (Journal Article)

ChemBioChem, 16 (7), pp. 1052-1059, 2015.

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Structure, activity and stereoselectivity of NADPH-dependent oxidoreductases catalysing the S-selective reduction of the imine substrate 2-methylpyrroline

Faber, K; Fessner, W -D; Turner, N J

Engineering biocatalysts for synthesis including cascade processes (Journal Article)

Advanced Synthesis and Catalysis, 357 (8), pp. 1565-1566, 2015.

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Engineering biocatalysts for synthesis including cascade processes

Parmeggiani, F; Lovelock, S L; Weise, N J; Ahmed, S T; Turner, N J

Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process (Journal Article)

Angewandte Chemie - International Edition, 54 (15), pp. 4608-4611, 2015.

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Synthesis of D- and L-Phenylalanine Derivatives by Phenylalanine Ammonia Lyases: A Multienzymatic Cascade Process

Köhler, V; Turner, N J

Artificial concurrent catalytic processes involving enzymes (Journal Article)

Chemical Communications, 51 (3), pp. 450-464, 2015.

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Artificial concurrent catalytic processes involving enzymes

Knaus, T; Mutti, F G; Humphreys, L D; Turner, N J; Scrutton, N S

Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes (Journal Article)

Organic and Biomolecular Chemistry, 13 (1), pp. 223-233, 2015.

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Systematic methodology for the development of biocatalytic hydrogen-borrowing cascades: Application to the synthesis of chiral α-substituted carboxylic acids from α-substituted α,β-unsaturated aldehydes

Hussain, S; Leipold, F; Man, H; Wells, E; France, S P; Mulholland, K R; Grogan, G; Turner, N J

An (R)-imine reductase biocatalyst for the asymmetric reduction of cyclic imines (Journal Article)

ChemCatChem, 7 (4), pp. 579-583, 2015.

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An (R)-imine reductase biocatalyst for the asymmetric reduction of cyclic imines

2014

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Lovelock, S L; Turner, N J

Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity (Journal Article)

Bioorganic and Medicinal Chemistry, 22 (20), pp. 5555-5557, 2014.

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Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity

Bechi, B; Herter, S; McKenna, S; Riley, C; Leimkühler, S; Turner, N J; Carnell, A J

Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis (Journal Article)

Green Chemistry, 16 (10), pp. 4524-4529, 2014.

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Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

Staniland, S; Yuan, B; Giménez-Agullõ, N; Marcelli, T; Willies, S C; Grainger, D M; Turner, N J; Clayden, J

Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers (Journal Article)

Chemistry - A European Journal, 20 (41), pp. 13084-13088, 2014.

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Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

Scheller, P N; Fademrecht, S; Hofelzer, S; Pleiss, J; Leipold, F; Turner, N J; Nestl, B M; Hauer, B

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases (Journal Article)

ChemBioChem, 15 (15), pp. 2201-2204, 2014.

(Links | BibTeX)

Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases

Schrittwieser, J H; Groenendaal, B; Willies, S C; Ghislieri, D; Rowles, I; Resch, V; Sattler, J H; Fischereder, E -M; Grischek, B; Lienhart, W -D; Turner, N J; Kroutil, W

Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants (Journal Article)

Catalysis Science and Technology, 4 (10), pp. 3657-3664, 2014.

(Links | BibTeX)

Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

Green, A P; Turner, N J; O'Reilly, E

Chiral amine synthesis using ω-transaminases: An amine donor that displaces equilibria and enables high-throughput screening (Journal Article)

Angewandte Chemie - International Edition, 53 (40), pp. 10714-10717, 2014.

(Links | BibTeX)

Chiral amine synthesis using ω-transaminases: An amine donor that displaces equilibria and enables high-throughput screening

Humphrey, C E; Ahmed, M; Ghanem, A; Turner, N J

Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions (Book)

2014.

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Lovelock, S L; Lloyd, R C; Turner, N J

Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway (Journal Article)

Angewandte Chemie - International Edition, 53 (18), pp. 4652-4656, 2014.

(Links | BibTeX)

Phenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway

Schrittwieser, J H; Groenendaal, B; Resch, V; Ghislieri, D; Wallner, S; Fischereder, E -M; Fuchs, E; Grischek, B; Sattler, J H; MacHeroux, P; Turner, N J; Kroutil, W

Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion (Journal Article)

Angewandte Chemie - International Edition, 53 (14), pp. 3731-3734, 2014.

(Links | BibTeX)

Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion

Ghislieri, D; Turner, N J

Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines (Journal Article)

Topics in Catalysis, 57 (5), pp. 284-300, 2014.

(Links | BibTeX)

Turner, N J; Whittall, J; Ward, T R

Foreword (Journal Article)

Topics in Catalysis, 57 (5), pp. 283, 2014.

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O'Reilly, E; Iglesias, C; Ghislieri, D; Hopwood, J; Galman, J L; Lloyd, R C; Turner, N J

A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines (Journal Article)

Angewandte Chemie - International Edition, 53 (9), pp. 2447-2450, 2014.

(Links | BibTeX)

A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines

Turner, N J

A Reduction of C N to CH-NH Using Enzymes and Microorganisms (Book)

2014.

(Links | BibTeX)

Turner, N J; Wells, A

The enzyme spring: Biocatalysis at its best (Journal Article)

ChemCatChem, 6 (4), pp. 900-901, 2014.

(Links | BibTeX)

The enzyme spring: Biocatalysis at its best

Heath, R S; Pontini, M; Bechi, B; Turner, N J

Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity (Journal Article)

ChemCatChem, 6 (4), pp. 996-1002, 2014.

(Links | BibTeX)

Development of an R-selective amine oxidase with broad substrate specificity and high enantioselectivity

O'Reilly, E; Iglesias, C; Turner, N J

Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines (Journal Article)

ChemCatChem, 6 (4), pp. 992-995, 2014.

(Links | BibTeX)

Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

Heap, L; Green, A; Brown, D; Dongen, Van B; Turner, N

Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification (Journal Article)

Catalysis Science and Technology, 4 (8), pp. 2251-2259, 2014.

(Links | BibTeX)

Role of laccase as an enzymatic pretreatment method to improve lignocellulosic saccharification

Zajkoska, P; Rosenberg, M; Heath, R; Malone, K J; Stloukal, R; Turner, N J; Rebroš, M

Immobilised whole-cell recombinant monoamine oxidase biocatalysis (Journal Article)

Applied Microbiology and Biotechnology, 99 (3), pp. 1229-1236, 2014.

(Links | BibTeX)

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Ghislieri, D; Houghton, D; Green, A P; Willies, S C; Turner, N J

Monoamine oxidase (MAO-N) catalyzed deracemization of tetrahydro-β- carbolines: Substrate dependent switch in enantioselectivity (Journal Article)

ACS Catalysis, 3 (12), pp. 2869-2872, 2013.

(Links | BibTeX)

Leipold, F; Hussain, S; Ghislieri, D; Turner, N J

Asymmetric reduction of cyclic imines catalyzed by a whole-cell biocatalyst containing an (S)-imine reductase (Journal Article)

ChemCatChem, 5 (12), pp. 3505-3508, 2013.

(Links | BibTeX)

Ghislieri, D; Green, A P; Pontini, M; Willies, S C; Rowles, I; Frank, A; Grogan, G; Turner, N J

Engineering an enantioselective amine oxidase for the synthesis of pharmaceutical building blocks and alkaloid natural products (Journal Article)

Journal of the American Chemical Society, 135 (29), pp. 10863-10869, 2013.

(Links | BibTeX)

Rodríguez-Mata, M; Frank, A; Wells, E; Leipold, F; Turner, N J; Hart, S; Turkenburg, J P; Grogan, G

Structure and activity of NADPH-dependent reductase Q1EQE0 from streptomyces kanamyceticus, which catalyses the R-selective reduction of an imine substrate (Journal Article)

ChemBioChem, 14 (11), pp. 1372-1379, 2013.

(Links | BibTeX)

O'Reilly, E; Corbett, M; Hussain, S; Kelly, P P; Richardson, D; Flitsch, S L; Turner, N J

Substrate promiscuity of cytochrome P450 RhF (Journal Article)

Catalysis Science and Technology, 3 (6), pp. 1490-1492, 2013.

(Links | BibTeX)

Turner, N J; Truppo, M D

Synthesis of Chiral Amines Using Transaminases (Book)

2013.

(Links | BibTeX)

Turner, N J; Truppo, M D

Biocatalysis enters a new era (Journal Article)

Current Opinion in Chemical Biology, 17 (2), pp. 212-214, 2013.

(Links | BibTeX)

Köhler, V; Wilson, Y M; Dürrenberger, M; Ghislieri, D; Churakova, E; Quinto, T; Knörr, L; Häussinger, D; Hollmann, F; Turner, N J; Ward, T R

Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes (Journal Article)

Nature Chemistry, 5 (2), pp. 93-99, 2013.

(Links | BibTeX)

Akhtara, Kalim M; Turner, N J; Jones, P R

Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities (Journal Article)

Proceedings of the National Academy of Sciences of the United States of America, 110 (1), pp. 87-92, 2013.

(Links | BibTeX)

Turner, N J; O'reilly, E

Biocatalytic retrosynthesis (Journal Article)

Nature Chemical Biology, 9 (5), pp. 285-288, 2013.

(Links | BibTeX)

Willies, S C; White, J L; Turner, N J

Development of a high-throughput screening method for racemase activity and its application to the identification of alanine racemase variants with activity towards l-arginine (Journal Article)

Tetrahedron, 68 (37), pp. 7564-7567, 2012.

(Links | BibTeX)

Turner, N J

7.1 Introduction and General Concepts (Book)

2012.

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Turner, N J

7.12 Oxidation: Oxidases (Book)

2012.

(Links | BibTeX)

Rowles, I; Malone, K J; Etchells, L L; Willies, S C; Turner, N J

Directed evolution of the enzyme monoamine oxidase (mao-n): Highly efficient chemo-enzymatic deracemisation of the alkaloid (±)-crispinea (Journal Article)

ChemCatChem, 4 (9), pp. 1259-1261, 2012.

(Links | BibTeX)

Turner, N J

Biocatalysis (Journal Article)

Catalysis Science and Technology, 2 (8), pp. 1523, 2012.

(Links | BibTeX)

March-Cortijos, A; Snape, T J; Turner, N J

Synthesis of 1,3-disubstituted azetidines via a tandem ring-opening ring-closing procedure (Journal Article)

Synlett, 23 (10), pp. 1511-1515, 2012.

(Links | BibTeX)

Turner, N J

Oxidation of C-N Bonds (Book)

2012.

(Links | BibTeX)

O'Reilly, E; Aitken, S J; Grogan, G; Kelly, P P; Turner, N J; Flitsch, S L

Regio- and stereoselective oxidation of unactivated C-H bonds with Rhodococcus rhodochrous (Journal Article)

Beilstein Journal of Organic Chemistry, 8 , pp. 496-500, 2012.

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Znabet, A; Blanken, S; Janssen, E; Kanter, De F J J; Helliwell, M; Turner, N J; Ruijter, E; Orru, R V A

Stereoselective synthesis of N-aryl proline amides by biotransformation- Ugi-Smiles sequence (Journal Article)

Organic and Biomolecular Chemistry, 10 (5), pp. 941-944, 2012.

(Links | BibTeX)

Foulkes, J M; Malone, K J; Coker, V S; Turner, N J; Lloyd, J R

Engineering a biometallic whole cell catalyst for enantioselective deracemization reactions (Journal Article)

ACS Catalysis, 1 (11), pp. 1589-1594, 2011.

(Links | BibTeX)

Robin, A; Köhler, V; Jones, A; Ali, A; Kelly, P P; O'Reilly, E; Turner, N J; Flitsch, S L

Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope (Journal Article)

Beilstein Journal of Organic Chemistry, 7 , pp. 1494-1498, 2011.

(Links | BibTeX)

Ioannou, A; Cini, E; Timofte, R S; Flitsch, S L; Turner, N J; Linclau, B

Heavily fluorinated carbohydrates as enzyme substrates: Oxidation of tetrafluorinated galactose by galactose oxidase (Journal Article)

Chemical Communications, 47 (40), pp. 11228-11230, 2011.

(Links | BibTeX)

Oneill, M; Hauer, B; Schneider, N; Turner, N J

Enzyme-catalyzed enantioselective hydrolysis of dihydrouracils as a route to enantiomerically pure Β-amino acids (Journal Article)

ACS Catalysis, 1 (9), pp. 1014-1016, 2011.

(Links | BibTeX)

Fessner, W -D; Turner, N J; Wang, M -X

Biocatalysis - A gateway to industrial biotechnology (Journal Article)

Advanced Synthesis and Catalysis, 353 (13), pp. 2189-2190, 2011.

(Links | BibTeX)

Turner, N J

Enantioselective Oxidation of C-O and C-N bonds using oxidases (Journal Article)

Chemical Reviews, 111 (7), pp. 4073-4087, 2011.

(Links | BibTeX)

Rannes, J B; Ioannou, A; Willies, S C; Grogan, G; Behrens, C; Flitsch, S L; Turner, N J

Glycoprotein labeling using engineered variants of galactose oxidase obtained by directed evolution (Journal Article)

Journal of the American Chemical Society, 133 (22), pp. 8436-8439, 2011.

(Links | BibTeX)

Turner, N J

Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids (Journal Article)

Current Opinion in Chemical Biology, 15 (2), pp. 234-240, 2011.

(Links | BibTeX)

Walker, R G; Thomson, G; Malone, K; Nowicki, M W; Brown, E; Blake, D G; Turner, N J; Walkinshaw, M D; Grant, K M; Mottram, J C

High throughput screens yield small molecule inhibitors of leishmania CRK3:CYC6 cyclin-dependent kinase (Journal Article)

PLoS Neglected Tropical Diseases, 5 (4), 2011.

(Links | BibTeX)

Dunsmore, C J; Malone, K J; Bailey, K R; Wear, M A; Florance, H; Shirran, S; Barran, P E; Page, A P; Walkinshaw, M D; Turner, N J

Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans (Journal Article)

ChemBioChem, 12 (5), pp. 802-810, 2011.

(Links | BibTeX)

O'Reilly, E; Köhler, V; Flitsch, S L; Turner, N J

Cytochromes P450 as useful biocatalysts: Addressing the limitations (Journal Article)

Chemical Communications, 47 (9), pp. 2490-2501, 2011.

(Links | BibTeX)

Hopwood, J; Truppo, M D; Turner, N J; Lloyd, R C

A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases (Journal Article)

Chemical Communications, 47 (2), pp. 773-775, 2011.

(Links | BibTeX)

Znabet, A; Polak, M M; Janssen, E; Kanter, De F J J; Turner, N J; Orru, R V A; Ruijter, E

A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions (Journal Article)

Chemical Communications, 46 (42), pp. 7918-7920, 2010.

(Links | BibTeX)

Znabet, A; Zonneveld, J; Janssen, E; Kanter, De F J J; Helliwell, M; Turner, N J; Ruijter, E; Orru, R V A

Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence (Journal Article)

Chemical Communications, 46 (41), pp. 7706-7708, 2010.

(Links | BibTeX)

Husi, H; McAllister, F; Angelopoulos, N; Butler, V J; Bailey, K R; Malone, K; MacKay, L; Taylor, P; Page, A P; Turner, N J; Barran, P E; Walkinshaw, M

Selective chemical intervention in the proteome of caenorhabditis elegans (Journal Article)

Journal of Proteome Research, 9 (11), pp. 6060-6070, 2010.

(Links | BibTeX)

Yuan, B; Page, A; Worrall, C P; Escalettes, F; Willies, S C; McDouall, J J W; Turner, N J; Clayden, J

Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases (Journal Article)

Angewandte Chemie - International Edition, 49 (39), pp. 7010-7013, 2010.

(Links | BibTeX)

Turner, N J; Truppo, M D

Biocatalytic Routes to Nonracemic Chiral Amines (Book)

2010.

(Links | BibTeX)

Znabet, A; Ruijter, E; Kanter, De F J J; Köhler, V; Helliwell, M; Turner, N J; Orru, R V A

Highly stereoselective synthesis of substituted prolyl peptides using a combination of biocatalytic desymmetrization and multicomponent reactions (Journal Article)

Angewandte Chemie - International Edition, 49 (31), pp. 5289-5292, 2010.

(Links | BibTeX)

Dunn, R V; Munro, A W; Turner, N J; Rigby, S E J; Scrutton, N S

Tyrosyl radical formation and propagation in flavin dependent monoamine oxidases (Journal Article)

ChemBioChem, 11 (9), pp. 1228-1231+1158, 2010.

(Links | BibTeX)

Sabbadin, F; Hyde, R; Robin, A; Hilgarth, E -M; Delenne, M; Flitsch, S; Turner, N; Grogan, G; Bruce, N C

LICRED: A versatile drop-in vector for rapid generation of redox-self-sufficient cytochrome P450s (Journal Article)

ChemBioChem, 11 (7), pp. 987-994, 2010.

(Links | BibTeX)

Turner, N J

Deracemisation methods (Journal Article)

Current Opinion in Chemical Biology, 14 (2), pp. 115-121, 2010.

(Links | BibTeX)

Köhler, V; Bailey, K R; Znabet, A; Raftery, J; Helliwell, M; Turner, N J

Enantioselective biocatalytic oxidative desymmetrization of substituted pyrrolidines (Journal Article)

Angewandte Chemie - International Edition, 49 (12), pp. 2182-2184, 2010.

(Links | BibTeX)

Truppo, M D; Turner, N J

Micro-scale process development of transaminase catalysed reactions (Journal Article)

Organic and Biomolecular Chemistry, 8 (6), pp. 1280-1283, 2010.

(Links | BibTeX)

Truppo, M D; Rozzell, David J; Turner, N J

Efficient production of enantiomerically pure chiral amines at concentrations of 50 g/L using transaminases (Journal Article)

Organic Process Research and Development, 14 (1), pp. 234-237, 2010.

(Links | BibTeX)

Ellis, A J; Reiss, R; Snape, T J; Turner, N J; Pezzotti, F; Therisod, H; Therisod, M; Kaup, B; Piantini, U; Wüst, M; Schrader, J; Chiappe, C; Colonna, S; Gaggero, N; Pellegrino, S; Zambianchi, F; Kirschner, A; Bornscheuer, U T; Grogan, G; Hill, C; Wang, S; Yang, J; Lau, P C K

Enzymatic Oxidation Chemistry (Book)

2009.

(Links | BibTeX)

Meyer, H -P; Turner, N J

Biotechnological manufacturing options for organic chemistry (Journal Article)

Mini-Reviews in Organic Chemistry, 6 (4), pp. 300-306, 2009.

(Links | BibTeX)

Robin, A; Roberts, G A; Kisch, J; Sabbadin, F; Grogan, G; Bruce, N; Turner, N J; Flitsch, S L

Engineering and improvement of the efficiency of a chimeric [P450cam-RhFRed reductase domain] enzyme (Journal Article)

Chemical Communications, (18), pp. 2478-2480, 2009.

(Links | BibTeX)

Truppo, M D; Turner, N J; Rozzell, J D

Efficient kinetic resolution of racemic amines using a transaminase in combination with an amino acid oxidase (Journal Article)

Chemical Communications, (16), pp. 2127-2129, 2009.

(Links | BibTeX)

Truppo, M D; Rozzell, J D; Moore, J C; Turner, N J

Rapid screening and scale-up of transaminase catalysed reactions (Journal Article)

Organic and Biomolecular Chemistry, 7 (2), pp. 395-398, 2009.

(Links | BibTeX)

Turner, N J

Directed evolution drives the next generation of biocatalysts (Journal Article)

Nature Chemical Biology, 5 (8), pp. 567-573, 2009.

(Links | BibTeX)

Atkin, K E; Reiss, R; Koehler, V; Bailey, K R; Hart, S; Turkenburg, J P; Turner, N J; Brzozowski, A M; Grogan, G

The Structure of Monoamine Oxidase from Aspergillus niger Provides a Molecular Context for Improvements in Activity Obtained by Directed Evolution (Journal Article)

Journal of Molecular Biology, 384 (5), pp. 1218-1231, 2008.

(Links | BibTeX)

Turner, N J

Chemoenzymatic Routes to Enantiomerically Pure Amino Acids and Amines (Book)

2008.

(Links | BibTeX)

Turner, N J

Deracemization and Enantioconvergent Processes (Book)

2008.

(Links | BibTeX)

Nowicki, M W; Tulloch, L B; Worralll, L; McNae, I W; Hannaert, V; Michels, P A M; Fothergill-Gilmore, L A; Walkinshaw, M D; Turner, N J

Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis (Journal Article)

Bioorganic and Medicinal Chemistry, 16 (9), pp. 5050-5061, 2008.

(Links | BibTeX)

Escalettes, F; Turner, N J

Directed evolution of galactose oxidase: Generation of enantioselective secondary alcohol oxidases (Journal Article)

ChemBioChem, 9 (6), pp. 857-860, 2008.

(Links | BibTeX)

Truppo, M D; Escalettes, F; Turner, N J

Rapid determination of both the activity and enantioselectivity of ketoreductases (Journal Article)

Angewandte Chemie - International Edition, 47 (14), pp. 2639-2641, 2008.

(Links | BibTeX)

Atkin, K E; Reiss, R; Turner, N J; Brzozowski, A M; Grogan, G

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of variants of monoamine oxidase from Aspergillus niger (Journal Article)

Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64 (3), pp. 182-185, 2008.

(Links | BibTeX)

Yang, Y; Moir, E; Kontopidis, G; Taylor, P; Wear, M A; Malone, K; Dunsmore, C J; Page, A P; Turner, N J; Walkinshaw, M D

Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans (Journal Article)

Biochemical and Biophysical Research Communications, 363 (4), pp. 1013-1019, 2007.

(Links | BibTeX)

Bailey, K R; Ellis, A J; Reiss, R; Snape, T J; Turner, N J

A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A (Journal Article)

Chemical Communications, (35), pp. 3640-3642, 2007.

(Links | BibTeX)

Eve, T S C; Wells, A; Turner, N J

Enantioselective oxidation of O-methyl-N-hydroxylamines using monoamine oxidase N as catalyst (Journal Article)

Chemical Communications, (15), pp. 1530-1531, 2007.

(Links | BibTeX)

Çelik, A; Roberts, G A; White, J H; Chapman, S K; Turner, N J; Flitsch, S L

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp. (Journal Article)

Chemical Communications, (43), pp. 4492-4494, 2006.

(Links | BibTeX)

Turner, N J

Agar Plate-based Assays (Book)

2006.

(Links | BibTeX)

Fotheringham, I; Archer, I; Carr, R; Speight, R; Turner, N J

Preparative deracemization of unnatural amino acids (Journal Article)

Biochemical Society Transactions, 34 (2), pp. 287-290, 2006.

(Links | BibTeX)

Dunsmore, C J; Carr, R; Fleming, T; Turner, N J

A chemo-enzymatic route to enantiomerically pure cyclic tertiary amines (Journal Article)

Journal of the American Chemical Society, 128 (7), pp. 2224-2225, 2006.

(Links | BibTeX)

Turner, N J; Carr, R

Biocatalytic routes to nonracemic chiral amines (Book)

2006.

(Links | BibTeX)

Wear, M A; Patterson, A; Malone, K; Dunsmore, C; Turner, N J; Walkinshaw, M D

A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A (Journal Article)

Analytical Biochemistry, 345 (2), pp. 214-226, 2005.

(Links | BibTeX)

Çelik, A; Flitsch, S L; Turner, N J

Efficient terpene hydroxylation catalysts based upon P450 enzymes derived from actinomycetes (Journal Article)

Organic and Biomolecular Chemistry, 3 (16), pp. 2930-2934, 2005.

(Links | BibTeX)

Çelik, A; Sperandio, D; Speight, R E; Turner, N J

Enantioselective epoxidation of linolenic acid catalysed by cytochrome P450BM3 from Bacillus megaterium (Journal Article)

Organic and Biomolecular Chemistry, 3 (15), pp. 2688-2690, 2005.

(Links | BibTeX)

Çelik, A; Speight, R E; Turner, N J

Identification of broad specificity P450CAM variants by primary screening against indole as substrate (Journal Article)

Chemical Communications, (29), pp. 3652-3654, 2005.

(Links | BibTeX)

Hunter, D J B; Roberts, G A; Ost, T W B; White, J H; Müller, S; Turner, N J; Flitsch, S L; Chapman, S K

Analysis of the domain properties of the novel cytochrome P450 RhF (Journal Article)

FEBS Letters, 579 (10), pp. 2215-2220, 2005.

(Links | BibTeX)

Carr, R; Alexeeva, M; Dawson, M J; Gotor-Fernández, V; Humphrey, C E; Turner, N J

Directed evolution of an amine oxidase for the preparative deracemisation of cyclic secondary amines (Journal Article)

ChemBioChem, 6 (4), pp. 637-639, 2005.

(Links | BibTeX)

Poondra, R R; Turner, N J

Microwave-assisted sequential amide bond formation and intramolecular amidation: A rapid entry to functionalized oxindoles (Journal Article)

Organic Letters, 7 (5), pp. 863-866, 2005.

(Links | BibTeX)

Poondra, R R; Fischer, P M; Turner, N J

Efficient palladium-catalyzed cross-coupling of β-chloroalkylidene/ arylidene malonates using microwave chemistry (Journal Article)

Journal of Organic Chemistry, 69 (20), pp. 6920-6922, 2004.

(Links | BibTeX)

Speight, R E; Hancock, F E; Winkel, C; Bevinakatti, H S; Sarkar, M; Flitsch, S L; Turner, N J

Rapid identification of cytochrome P450 cam variants by in vivo screening of active site libraries (Journal Article)

Tetrahedron Asymmetry, 15 (18), pp. 2829-2831, 2004.

(Links | BibTeX)

Moore, B D; Stevenson, L; Watt, A; Flitsch, S; Turner, N J; Cassidy, C; Graham, D

Rapid and ultra-sensitive determination of enzyme activities using surface-enhanced resonance Raman scattering (Journal Article)

Nature Biotechnology, 22 (9), pp. 1133-1138, 2004.

(Links | BibTeX)

Humphrey, C E; Easson, M A M; Turner, N J

Dimedone esters as novel hydrolase substrates and their application in the colorimetric detection of lipase and esterase activity (Journal Article)

ChemBioChem, 5 (8), pp. 1144-1148, 2004.

(Links | BibTeX)

Roff, G J; Lloyd, R C; Turner, N J

A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids (Journal Article)

Journal of the American Chemical Society, 126 (13), pp. 4098-4099, 2004.

(Links | BibTeX)

Turner, N J

Enzyme catalysed deracemisation and dynamic kinetic resolution reactions (Journal Article)

Current Opinion in Chemical Biology, 8 (2), pp. 114-119, 2004.

(Links | BibTeX)

Roberts, G A; Grogan, G; Turner, N J; Flitsch, S L

Nucleotide sequence of a portion of the camphor-degrading gene cluster from Rhodococcus sp. NCIMB 9784 (Journal Article)

DNA Sequence - Journal of DNA Sequencing and Mapping, 15 (2), pp. 96-103, 2004.

(Links | BibTeX)

Lins, R J; Flitsch, S L; Turner, N J; Irving, E; Brown, S A

Generation of a dynamic combinatorial library using sialic acid aldolase and in situ screening against wheat germ agglutinin (Journal Article)

Tetrahedron, 60 (3), pp. 771-780, 2004.

(Links | BibTeX)

Alexeeva, M; Carr, R; Turner, N J

Directed evolution of enzymes: New biocatalysts for asymmetric synthesis (Journal Article)

Organic and Biomolecular Chemistry, 1 (23), pp. 4133-4137, 2003.

(Links | BibTeX)

Humphrey, C E; Turner, N J; Easson, M A M; Flitsch, S L; Ulijn, R V

Lipase-Catalyzed Kinetic Resolution on Solid-Phase via a "Capture and Release" Strategy (Journal Article)

Journal of the American Chemical Society, 125 (46), pp. 13952-13953, 2003.

(Links | BibTeX)

Carr, R; Alexeeva, M; Enright, A; Eve, T S C; Dawson, M J; Turner, N J

Directed Evolution of an Amine Oxidase Possessing both Broad Substrate Specificity and High Enantioselectivity (Journal Article)

Angewandte Chemie - International Edition, 42 (39), pp. 4807-4810, 2003.

(Links | BibTeX)

Humphrey, C E; Easson, M A M; Tierney, J P; Turner, N J

Solid-supported cyclohexane-1,3-dione (CHD): A "capture and release" reagent for the synthesis of amides and novel scavenger resin (Journal Article)

Organic Letters, 5 (6), pp. 849-852, 2003.

(Links | BibTeX)

Hull, J D; Scheinmann, F; Turner, N J

Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations (Journal Article)

Tetrahedron Asymmetry, 14 (5), pp. 567-576, 2003.

(Links | BibTeX)

Turner, N J

Directed evolution of enzymes for applied biocatalysis (Journal Article)

Trends in Biotechnology, 21 (11), pp. 474-478, 2003.

(Links | BibTeX)

Turner, N J

Controlling chirality (Journal Article)

Current Opinion in Biotechnology, 14 (4), pp. 401-406, 2003.

(Links | BibTeX)

Enright, A; Alexandre, F R; Roff, G; Fotheringham, I G; Dawson, M J; Turner, N J

Stereoinversion of β- and γ-substituted α-amino acids using a chemo-enzymatic oxidation-reduction procedure (Journal Article)

Chemical Communications, 3 (20), pp. 2636-2637, 2003.

(Links | BibTeX)

Roberts, G A; Celik, A; Hunter, D J; Ost, T W; White, J H; Chapman, S K; Turner, N J; Flitsch, S L

A self-sufficient cytochrome p450 with a primary structural organization that includes a flavin domain and a [2Fe-2S] redox center. (Journal Article)

The Journal of biological chemistry, 278 (49), pp. 48914-48920, 2003.

(Links | BibTeX)

Grogan, G; Roberts, G; Parsons, S; Turner, N; Flitsch, S

P450camr, a cytochrome P450 catalysing the stereospecific 6-endo-hydroxylation of (1R)-(+)-camphor (Journal Article)

Applied Microbiology and Biotechnology, 59 (4-5), pp. 449-454, 2002.

(Links | BibTeX)

Lins, R J; Flitsch, S L; Turner, N J; Irving, E; Brown, S A

Enzymatic generation and in situ screening of a dynamic combinatorial library of sialic acid analogues (Journal Article)

Angewandte Chemie - International Edition, 41 (18), pp. 3405-3407, 2002.

(Links | BibTeX)

Alexeeva, M; Enright, A; Dawson, M J; Mahmoudian, M; Turner, N J

Deracemization of α-methylbenzylamine using an enzyme obtained by in vitro evolution (Journal Article)

Angewandte Chemie - International Edition, 41 (17), pp. 3177-3180, 2002.

(Links | BibTeX)

Roberts, G A; Grogan, G; Greter, A; Flitsch, S L; Turner, N J

Identification of a new class of cytochrome P450 from a Rhodococcus sp. (Journal Article)

Journal of Bacteriology, 184 (14), pp. 3898-3908, 2002.

(Links | BibTeX)

Alexandre, F -R; Pantaleone, D P; Taylor, P P; Fotheringham, I G; Ager, D J; Turner, N J

Amine-boranes: Effective reducing agents for the deracemisation of DL-amino acids using L-amino acid oxidase from Proteus myxofaciens (Journal Article)

Tetrahedron Letters, 43 (4), pp. 707-710, 2002.

(Links | BibTeX)

Beard, T M; Turner, N J

Deracemisation and stereoinversion of α-amino acids using D-amino acid oxidase and hydride reducing agents (Journal Article)

Chemical Communications, 2 (3), pp. 246-247, 2002.

(Links | BibTeX)

Cass, T; Dunwell, J; Wackett, L P; Gilardi, G; Kost, T A; Condreay, P; Projan, S; Hugenholtz, J; Kleerebezem, M; Turner, N J; Speight, R E

Biotechnology. Paper Alert. (Journal Article)

Current opinion in biotechnology, 13 (1), pp. 1-8, 2002.

(Links | BibTeX)

Quirós, M; Parker, M -C; Turner, N J

Tuning lipase enantioselectivity in organic media using solid-state buffers (Journal Article)

Journal of Organic Chemistry, 66 (15), pp. 5074-5079, 2001.

(Links | BibTeX)

Grogan, G; Roberts, G A; Bougioukou, D; Turner, N J; Flitsch, S L

The desymmetrization of bicyclic β-diketones by an enzymatic retro-Claisen reaction. A new reaction of the crotonase superfamily (Journal Article)

Journal of Biological Chemistry, 276 (16), pp. 12565-12572, 2001.

(Links | BibTeX)

Grogan, G; Graf, J; Jones, A; Parsons, S; Turner, N J; Flitsch, S L

An asymmetric enzyme-catalyzed retro-claisen reaction for the desymmetrization of cyclic β-diketones (Journal Article)

Angewandte Chemie - International Edition, 40 (6), pp. 1111-1114, 2001.

(Links | BibTeX)

Grogan, G; Sime, J T; Turner, N J

Diastereoselective hydroxylation and reduction of derivatised tetrahydrofurans by Beauveria bassiana (Journal Article)

Biotechnology Letters, 23 (2), pp. 119-124, 2001.

(Links | BibTeX)

Humphrey, A J; Parsons, S F; Smith, M E B; Turner, N J

Synthesis of a novel N-hydroxypyrrolidine using enzyme catalysed asymmetric carbon-carbon bond synthesis (Journal Article)

Tetrahedron Letters, 41 (22), pp. 4481-4485, 2000.

(Links | BibTeX)

Brown, S A; Parker, M -C; Turner, N J

Dynamic kinetic resolution: Synthesis of optically active α-amino acid derivatives (Journal Article)

Tetrahedron Asymmetry, 11 (8), pp. 1687-1690, 2000.

(Links | BibTeX)

Jenkins, G N; Stachulski, A V; Scheinmann, F; Turner, N J

The enzymatic glucuronidation of 3-O-protected morphine - A new route to 7,8-dihydromorphine-6-glucuronide (Journal Article)

Tetrahedron Asymmetry, 11 (2), pp. 413-416, 2000.

(Links | BibTeX)

Turner, N J

Applications of transketolases in organic synthesis (Journal Article)

Current Opinion in Biotechnology, 11 (6), pp. 527-531, 2000.

(Links | BibTeX)

Turner, N; Schneider, M

Biocatalysis and biotransformation Biocatalysis molecular, structural and synthetic advances (Journal Article)

Current Opinion in Chemical Biology, 4 (1), pp. 65-67, 2000.

(Links | BibTeX)

Taylor, P; Anderson, V; Dowden, J; Flitsch, S L; Turner, N J; Loughran, K; Walkinshaw, M D

Novel mechanism of inhibition of elastase by β-lactams is defined by two inhibitor crystal complexes (Journal Article)

Journal of Biological Chemistry, 274 (35), pp. 24901-24905, 1999.

(Links | BibTeX)

Parker, M -C; Brown, S A; Robertson, L; Turner, N J

Enhancement of Candida antarctica lipase B enantioselectivity and activity in organic solvents (Journal Article)

Chemical Communications, (20), pp. 2247-2248, 1998.

(Links | BibTeX)

Mahmoudian, M; Rudd, B A M; Cox, B; Drake, C S; Hall, R M; Stead, P; Dawson, M J; Chandler, M; Livermore, D G; Turner, N J; Jenkins, G

A versatile procedure for the generation of nucleoside 5'- carboxylic acids using nucleoside oxidase (Journal Article)

Tetrahedron, 54 (28), pp. 8171-8182, 1998.

(Links | BibTeX)

Böhm, G; Dowden, J; Rice, D C; Burgess, I; Pilard, J -F; Guilbert, B; Haxton, A; Hunter, R C; Turner, N J; Flitsch, S L

A novel linker for the attachment of alcohols to solid supports (Journal Article)

Tetrahedron Letters, 39 (22), pp. 3819-3822, 1998.

(Links | BibTeX)

Aitken, S J; Grogan, G; Chow, C S -Y; Turner, N J; Flitsch, S L

Biohydroxylations of Cbz-protected alkyl substituted piperidines by Beauveria bassiana ATCC 7159 (Journal Article)

Journal of the Chemical Society - Perkin Transactions 1, (20), pp. 3365-3370, 1998.

(Links | BibTeX)

Roussel, P G; Sik, V; Turner, N J; Dinan, L N

Synthesis and biological activity of side-chain analogues of ecdysone and 20-hydroxyecdysone (Journal Article)

Journal of the Chemical Society - Perkin Transactions 1, (15), pp. 2237-2246, 1997.

(Links | BibTeX)

Blackie, J A; Turner, N J; Wells, A S

Concerning the baker's yeast (Saccharomyces cerevisiae) mediated reduction of nitroarenes and other N-O containing functional groups (Journal Article)

Tetrahedron Letters, 38 (17), pp. 3043-3046, 1997.

(Links | BibTeX)

Yagnik, A T; Littlechild, J A; Turner, N J

Molecular modelling studies of substrate binding to the lipase from Rhizomucor miehei (Journal Article)

Journal of Computer-Aided Molecular Design, 11 (3), pp. 256-264, 1997.

(Links | BibTeX)

Turner, N J

The application of enzymes in the synthesis of amino acids, peptides and carbohydrates (Journal Article)

Current Organic Chemistry, 1 (1), pp. 21-36, 1997.

(Links | BibTeX)

Routledge, A; Stock, H T; Flitsch, S L; Turner, N J

New fluoride-labile linkers for solid-phase organic synthesis (Journal Article)

Tetrahedron Letters, 38 (47), pp. 8287-8290, 1997.

(Links | BibTeX)

Maddrell, S J; Turner, N J; Kerridge, A; Willetts, A J; Crosby, J

Nitrile hydratase enzymes in organic synthesis: Enantioselective synthesis of the lactone moiety of the mevinic acids (Journal Article)

Tetrahedron Letters, 37 (33), pp. 6001-6004, 1996.

(Links | BibTeX)

Stock, H T; Turner, N J

Crystallisation-induced dynamic resolution of dipeptide-derived 5(4H)-oxazolones (Journal Article)

Tetrahedron Letters, 37 (36), pp. 6575-6578, 1996.

(Links | BibTeX)

Morris, K G; Smith, M E B; Turner, N J; Lilly, M D; Mitra, R K; Woodley, J M

Transketolase from Escherichia coli: A practical procedure for using the biocatalyst for asymmetric carbon-carbon bond synthesis (Journal Article)

Tetrahedron Asymmetry, 7 (8), pp. 2185-2188, 1996.

(Links | BibTeX)

Lilly, M D; Chauhan, R; French, C; Gyamerah, M; Hobbs, G R; Humphrey, A; Isupov, M; Littlechild, J A; Mitra, R K; Morris, K G; Rupprecht, M; Turner, N J; Ward, J M; Willetts, A J; Woodley, J M

Carbon-carbon bond synthesis: The impact of rDNA technology on the production and use of E. coli transketolase (Journal Article)

Annals of the New York Academy of Sciences, 782 , pp. 513-525, 1996.

(Links | BibTeX)

Jenkins, G N; Turner, N J

The biosynthesis of carbocyclic nucleosides (Journal Article)

Chemical Society Reviews, 24 (3), pp. 169-176, 1995.

(Links | BibTeX)

Roussel, P G; Turner, N J; Dinan, L N

Synthesis of shidasterone and the unambiguous determination of its configuration at C-22 (Journal Article)

Journal of the Chemical Society, Chemical Communications, (9), pp. 933-934, 1995.

(Links | BibTeX)

Humphrey, A J; Turner, N J; McCague, R; Taylor, S J C

Synthesis of enantiomerically pure α-hydroxyaldehydes from the corresponding α-hydroxycarboxylic acids: Novel substrates for Escherichia coli transketolase (Journal Article)

Journal of the Chemical Society, Chemical Communications, (24), pp. 2475-2476, 1995.

(Links | BibTeX)

Stock, H T; Turner, N J; McCague, R

N-(2-carboxybenzoyl)-L-phenylalanylglycine: A low molecular-mass gelling agent (Journal Article)

Journal of the Chemical Society, Chemical Communications, (20), pp. 2063-2064, 1995.

(Links | BibTeX)

Littlechild, J; Turner, N; Hobbs, G; Lilly, M; Rawas, A; Watson, H

Crystallization and preliminary X-ray crystallographic data with Escherichia coli transketolase (Journal Article)

Acta Crystallographica Section D: Biological Crystallography, 51 (6), pp. 1074-1076, 1995.

(Links | BibTeX)

Brown, R T; Carter, N E; Scheinmann, F; Turner, N J

Synthesis of morphine-6-glucuronide via a highly selective enzyme catalysed hydrolysis reaction (Journal Article)

Tetrahedron Letters, 36 (7), pp. 1117-1120, 1995.

(Links | BibTeX)

Turner, N J; Winterman, J R; McCague, R; Parratt, J S; Taylor, S J C

Synthesis of homochiral l-(S)-tert-leucine via a lipase catalysed dynamic resolution process (Journal Article)

Tetrahedron Letters, 36 (7), pp. 1113-1116, 1995.

(Links | BibTeX)

Hill, J M; Jenkins, G N; Turner, N J; Rush, C P; Willetts, A J; Buss, A D; Dawson, M J; Rudd, B A M

Revised Pathway for the Biosynthesis of Aristeromycin and Neplanocin A from D-Glucose in Streptomyces citricolor (Journal Article)

Journal of the American Chemical Society, 117 (19), pp. 5391-5392, 1995.

(Links | BibTeX)

Crosby, J; Moilliet, J; Parratt, J S; Turner, N J

Regioselective hydrolysis of aromatic dinitriles using a whole cell catalyst (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (13), pp. 1679-1687, 1994.

(Links | BibTeX)

Hill, J M; Hutchinson, E J; Grand, Le D M; Roberts, S M; Thorpe, A J; Turner, N J

Preparation of neplanocin-A from D-ribose and by a chemoenzymic method (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (11), pp. 1483-1487, 1994.

(Links | BibTeX)

Davey, C L; Powell, L W; Turner, N J; Wells, A

Regioselective reduction of substituted dinitroarenes using baker's yeast (Journal Article)

Tetrahedron Letters, 35 (42), pp. 7867-7870, 1994.

(Links | BibTeX)

Turner, N J

Recent advances in the use of enzyme-catalysed reactions in organic synthesis (Journal Article)

Natural Product Reports, 11 , pp. 1-15, 1994.

(Links | BibTeX)

Baker, A; Turner, N J; Webberley, M C

An improved strategy for the stereoselective synthesis of glycosides using glycosidases as catalysts (Journal Article)

Tetrahedron: Asymmetry, 5 (12), pp. 2517-2522, 1994.

(Links | BibTeX)

Kerridge, A; Parratt, J S; Roberts, S M; Theil, F; Turner, N J; Willetts, A J

Microbial hydrolysis of glutaronitrile derivatives with brevibacterium sp. R 312 (Journal Article)

Bioorganic and Medicinal Chemistry, 2 (6), pp. 447-455, 1994.

(Links | BibTeX)

Pallanca, J E; Turner, N J

Chemo-enzymic synthesis of guanosine 5′-diphosphomannose (GDP-mannose) and selected analogues (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (23), pp. 3017-3022, 1993.

(Links | BibTeX)

Brackenridge, I; McCague, R; Roberts, S M; Turner, N J

Enzymatic resolution of oxalate esters of a tertiary alcohol using porcine pancreatic lipase (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (10), pp. 1093-1094, 1993.

(Links | BibTeX)

Hobbs, G R; Lilly, M D; Turner, N J; Ward, J M; Willets, A J; Woodley, J M

Enzyme-catalysed carbon-carbon bond formation: Use of transketolase from Escherichia coli (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (2), pp. 165-166, 1993.

(Links | BibTeX)

Roberts, S M; Thorpe, A J; Turner, N J; Blows, W M; Buss, A D; Dawson, M J; Noble, D; Rudd, B A M; Sidebottom, P J; Wall, W F

The isolation and absolute configuration of (1S,2S,3R)-4- Hydroxymethylcyclopent-4-ene-1,2,3-triol: A putative intermediate in the biosynthesis of aristeromycin by Streptomyces citricolor (Journal Article)

Tetrahedron Letters, 34 (25), pp. 4083-4086, 1993.

(Links | BibTeX)

Pallanca, J E; Turner, N J

Chemo-enzymic synthesis of guanosine 5'-diphosphomannose (GDP-mannose) and selected analogues (Journal Article)

J.CHEM.SOC.PERKIN TRANS.1, (23), pp. 3017-3022, 1993.

(Links | BibTeX)

Wilson, I B H; Taylor, J P; Webberley, M C; Turner, N J; Flitsch, S L

A novel mono-branched lipid phosphate acts as a substrate for dolichyl phosphate mannose synthetase (Journal Article)

Biochemical Journal, 295 (1), pp. 195-201, 1993.

(Links | BibTeX)

Beard, T; Cohen, M A; Parratt, J S; Turner, N J; Crosby, J; Moilliet, J

Stereoselective hydrolysis of nitriles and amides under mild conditions using a whole cell catalyst (Journal Article)

Tetrahedron: Asymmetry, 4 (6), pp. 1085-1104, 1993.

(Links | BibTeX)

Floyd, N C; Liebster, M H; Turner, N J

A simple strategy for obtaining both enantiomers from an aldolase reaction: Preparation of L- and D-4-hydroxy-2-ketoglutarate (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (9), pp. 1085-1086, 1992.

(Links | BibTeX)

Flitsch, S L; Pinches, H L; Taylor, J P; Turner, N J

Chemo-enzymatic synthesis of a lipid-linked core trisaccharide of N-linked glycoproteins (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (16), pp. 2087-2093, 1992.

(Links | BibTeX)

Chinn, M J; Iacazio, G; Spackman, D G; Turner, N J; Roberts, S M

Regioselective enzymatic acetylation of methyl 4,6-O-benzylidene-α- and β-D-glucopyranoside (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (6), pp. 661-662, 1992.

(Links | BibTeX)

Chinn, M J; Iacazio, G; Spackman, D G; Turner, N J; Roberts, S M

Erratum: Regioselective enzymatic acetylation of methyl 4,6-O-benzylidene-α- and β-D-glucopyranoside (Journal of the Chemical Society, Perkin Transactions 1 (1992), (661)) (Journal Article)

Journal of the Chemical Society, Perkin Transactions 1, (15), pp. 2045, 1992.

(Links | BibTeX)

Roberts, S M; Turner, N J

Some recent developments in the use of enzyme catalysed reactions in organic synthesis (Journal Article)

Journal of Biotechnology, 22 (3), pp. 227-244, 1992.

(Links | BibTeX)

Cohen, M A; Parratt, J S; Turner, N J

Enantioselective hydrolysis of nitriles and amides using an immobilised whole cell system (Journal Article)

Tetrahedron: Asymmetry, 3 (12), pp. 1543-1546, 1992.

(Links | BibTeX)

Crosby, J A; Parratt, J S; Turner, N J

Enzymic hydrolysis of prochiral dinitriles (Journal Article)

Tetrahedron: Asymmetry, 3 (12), pp. 1547-1550, 1992.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Crouch, N P; Schofield, C J; Turner, N J; Aplin, R T

Cephalosporin biosynthesis: A branched pathway sensitive to an isotope effect (Journal Article)

Tetrahedron, 47 (47), pp. 9881-9900, 1991.

(Links | BibTeX)

Turner, N J; Webberley, M C

Stereospecific attachment of carbohydrates to amino acid derivatives using β-glucosidase and β-xylosidase (Journal Article)

Journal of the Chemical Society, Chemical Communications, (19), pp. 1349-1350, 1991.

(Links | BibTeX)

Flitsch, S L; Taylor, J P; Turner, N J

Synthesis of a novel acceptor substrate for a mannosyl transferase (Journal Article)

Journal of the Chemical Society, Chemical Communications, (6), pp. 380-382, 1991.

(Links | BibTeX)

Flitsch, S L; Taylor, J P; Turner, N J

Chemo-enzymatic synthesis of a β-mannosyl-containing trisaccharide (Journal Article)

Journal of the Chemical Society, Chemical Communications, (6), pp. 382-384, 1991.

(Links | BibTeX)

Baldwin, J E; Bradley, M; Turner, N J; Adlington, R M; Pitt, A R; Derome, A E

Enzymic conversion of deuterated analogues of δ-l-α-aminoadipoyl-l-cysteinyl-d-allylglycine, an unnatural substrate for isopenicilin n synthase: A unified theory of second ring closure. (Journal Article)

Tetrahedron, 47 (38), pp. 8223-8242, 1991.

(Links | BibTeX)

Baldwin, J E; Bradley, M; Turner, N J; Adlington, R M; Pitt, A R; Sheridan, H

Synthesis of δ-L-α-aminoadipoyl-L-cysteinyl-D-allylglycine, and eight deuterated analogues, substrates for the investigation of the mechanism of action of isopenicillin n synthase. (Journal Article)

Tetrahedron, 47 (38), pp. 8203-8222, 1991.

(Links | BibTeX)

Macfarlane, E L A; Rebolledo, F; Roberts, S M; Turner, N J

Some interesterification reactions involving mucor miehei lipase (Journal Article)

Biocatalysis and Biotransformation, 5 (1), pp. 13-19, 1991.

(Links | BibTeX)

Baldwin, J E; Bradley, M; Adlington, R M; Norris, W J; Turner, N J

Further evidence for the involvement of a monocyclic β-lactam in the enzymatic conversion of δ-L-α-aminoadipoyl-L-cysteinyl-D-valine into isopenicillin N. (Journal Article)

Tetrahedron, 47 (3), pp. 457-480, 1991.

(Links | BibTeX)

MacFarlane, E L A; Roberts, S M; Turner, N J

Enzyme-catalysed inter-esterification procedure for the preparation of esters of a chiral secondary alcohol in high enantiomeric purity (Journal Article)

Journal of the Chemical Society, Chemical Communications, (7), pp. 569-571, 1990.

(Links | BibTeX)

Turner, N J

Enzyme chemistry (Journal Article)

Annual Reports on the Progress of Chemistry - Section B, 87 , pp. 333-345, 1990.

(Links | BibTeX)

Cohen, M A; Sawden, J; Turner, N J

Selective hydrolysis of nitriles under mild conditions by an enzyme. (Journal Article)

Tetrahedron Letters, 31 (49), pp. 7223-7226, 1990.

(Links | BibTeX)

Turner, N J

Enzyme chemistry (Journal Article)

Annual Reports on the Progress of Chemistry - Section B, 86 , pp. 307-323, 1989.

(Links | BibTeX)

Turner, N J

Recent advances in the use of enzyme-catalysed reactions in organic synthesis (Journal Article)

Natural Product Reports, 6 (6), pp. 625-644, 1989.

(Links | BibTeX)

Turner, N J; Whitesides, G M

A Combined Chemical—Enzymatic Synthesis of 3-Deoxy-D-arabino-heptulosonic Acid 7-Phosphate (Journal Article)

Journal of the American Chemical Society, 111 (2), pp. 624-627, 1989.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Crouch, N P; Turner, N J; Schofield, C J

Cephalosporin C biosynthesis; stereochemistry of the incorporation of D,L,D-α-aminodipoyl-cysteinyl-(3S)-[2-2H,4-13C] valine into β-lactam compounds (Journal Article)

Journal of the Chemical Society, Chemical Communications, (16), pp. 1141-1143, 1989.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Bradley, M; Turner, N J; Pitt, A R

Evidence for epoxide formation from isopenicillin N synthase (Journal Article)

Journal of the Chemical Society, Chemical Communications, (15), pp. 978-981, 1989.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Basak, A; Imming, P; Ponnamperuma, K; Ronneberg, H; Schofield, C J; Ting, H; Turner, N J

Penicillin biosynthesis: Active substrates derived by methoxy substitution in the valinyl residue of the natural substrate (Journal Article)

Journal of the Chemical Society, Chemical Communications, (12), pp. 802-804, 1989.

(Links | BibTeX)

Turner, N J

Biological chemistry part (I) enzyme chemistry (Journal Article)

Annual Reports on the Progress of Chemistry - Section B, 85 , pp. 307-320, 1988.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Bradley, M; Norris, W J; Turner, N J; Yoshida, A

Identification and characterisation of shunt metabolites from isopenicillin N synthase (Journal Article)

Journal of the Chemical Society, Chemical Transactions, (16), pp. 1125-1128, 1988.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Bradley, M; Norris, W J; Turner, N J; Yoshida, A

Identification and characterisation of shunt metabolites from isopenicillin N synthase (Journal Article)

Journal of the Chemical Society - Series Chemical Communications, (16), pp. 1125-1128, 1988.

(Links | BibTeX)

Baldwin, J E; Pratt, A J; Sutherland, J D; Turner, N J; Crabbe, M J

Purification and characterization of cloned isopenicillin N synthetase (Journal Article)

The Journal of Antibiotics, 40 (5), pp. 652-659, 1987.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Domayne-Hayman, B P; Ting, H -H; Turner, N J

Stereospecificity of carbon-sulphur bond formation in penicillin biosynthesis (Journal Article)

Journal of the Chemical Society, Chemical Communications, (2), pp. 110-113, 1986.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Flitsch, S L; Ting, H -H; Turner, N J

Penicillin biosynthesis: The origin of hydroxy groups in β-lactams derived from unsaturated substrates (Journal Article)

Journal of the Chemical Society, Chemical Communications, (17), pp. 1305-1308, 1986.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Basak, A; Flitsch, S L; Petursson, S; Turner, N J; Ting, H -H

Enzymatic synthesis of a new type of penicillin (Journal Article)

Journal of the Chemical Society, Chemical Communications, (12), pp. 975-976, 1986.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Derome, A E; Ting, H -H; Turner, N J

Penicillin biosynthesis: Multiple pathways from a modified substrate (Journal Article)

Journal of the Chemical Society, Chemical Communications, (18), pp. 1211-1214, 1984.

(Links | BibTeX)

Baldwin, J E; Adlington, R M; Turner, N J; Domayne-Hayman, B P; Ting, H -H; Derome, A E; Murphy, J A

Penicillin biosynthesis: Enzymatic synthesis of new cephams (Journal Article)

Journal of the Chemical Society, Chemical Communications, (17), pp. 1167-1170, 1984.

(Links | BibTeX)

Baldwin, J E; Abraham, E P; Adlington, R M; Bahadur, G A; Chakravarti, B; Domayne-Hayman, B P; Field, L D; Flitsch, S L; Jayatilake, G S; Špakovskis, A; Ting, H -H; Turner, N J; White, R L; Usher, J J

Penicillin biosynthesis: Active site mapping with aminoadipoylcysteinylvaline variants (Journal Article)

Journal of the Chemical Society, Chemical Communications, (18), pp. 1225-1227, 1984.

(Links | BibTeX)