CONTINUOUS FLOW FOR BIOCATALYSIS
The use of flow chemistry, that is, the continuous pumping of chemical reactions through tubular reactors, has become a key technology in recent decades. It is now also seeing increased use in biocatalysis as well, with benefits such as enzyme/co-factor recycling and reduced reaction times making it feasible for more applied uses in organic synthesis.
We have recently demonstrated the use of immobilised biocatalysts, both in batch and flow, for increased efficiency versus soluble proteins. Using a porous affinity resin, EziGTM, we have shown that several reactions can be transferred into continuous flow with significant increases in productivity.